产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (236A/E7), APC, eBioscience™
目录 :
17-4777-42
规格 :
100试验
价格 :
美国389
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
APC
克隆名称 :
236a/E7
反应物种 :
人类, 猕猴
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 72
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 3a
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed 出版商
  • 流式细胞仪; 人类; 图 3b
Szabo P, Goswami A, Mazzuca D, Kim K, O Gorman D, Hess D, et al. Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology. J Immunol. 2017;198:2805-2818 pubmed 出版商
  • 流式细胞仪; 人类
Stikvoort A, Sundin M, Uzunel M, Gertow J, Sundberg B, Schaffer M, et al. Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?. PLoS ONE. 2016;11:e0154737 pubmed 出版商
  • 流式细胞仪; 人类; 图 1a
Goldstein J, Burlion A, Zaragoza B, Sendeyo K, Polansky J, Huehn J, et al. Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression. PLoS ONE. 2016;11:e0153682 pubmed 出版商
  • 流式细胞仪; 人类; 图 8
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  • 流式细胞仪; 人类
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Chauvin C, Levillayer L, Roumier M, Nielly H, Roth C, Karnam A, et al. Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants. iScience. 2023;26:106124 pubmed 出版商
Liu Y, Zhao N, Xu Q, Deng F, Wang P, Dong L, et al. MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis. J Inflamm Res. 2022;15:4315-4329 pubmed 出版商
Lee J, Chen M, Chou K, Chao Y, Chen M, Tsai C. Novel immunoprofiling method for diagnosing SLE and evaluating therapeutic response. Lupus Sci Med. 2022;9: pubmed 出版商
Piekarska K, Urban Wójciuk Z, Kurkowiak M, Pelikant Małecka I, Schumacher A, Sakowska J, et al. Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity. Nat Commun. 2022;13:856 pubmed 出版商
Hu Y, Chen Y, Chen Z, Zhang X, Guo C, Yu Z, et al. Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients. Front Cell Dev Biol. 2021;9:799560 pubmed 出版商
Li J, Wang S, Wang N, Zheng Y, Yang B, Wang X, et al. Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration. Cell Commun Signal. 2021;19:89 pubmed 出版商
Ye L, Peng W, Niu Y, Xiang X, Wei X, Wang Z, et al. Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis. Ann Transl Med. 2020;8:1647 pubmed 出版商
Meggyes M, Nagy D, Szereday L. Investigation of the PD-1 and PD-L1 Immune Checkpoint Molecules Throughout Healthy Human Pregnancy and in Nonpregnant Women. J Clin Med. 2020;9: pubmed 出版商
He J, Xu Y, Yi M, Gu C, Zhu Y, Hu G. Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain. J Int Med Res. 2020;48:300060519871407 pubmed 出版商
Wang A, Yang M, Liang R, Zhu F, Zhu F, Liu X, et al. Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function. Front Immunol. 2020;11:1087 pubmed 出版商
Imura Y, Ando M, Kondo T, Ito M, Yoshimura A. CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD. JCI Insight. 2020;5: pubmed 出版商
Blümel E, Munir Ahmad S, Nastasi C, Willerslev Olsen A, Gluud M, Fredholm S, et al. Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. Oncoimmunology. 2020;9:1751561 pubmed 出版商
Voss K, Lake C, Luthers C, Lott N, Dorjbal B, Arjunaraja S, et al. FOXP3 protects conventional human T cells from premature restimulation-induced cell death. Cell Mol Immunol. 2019;: pubmed 出版商
Hou T, Qureshi O, Sansom D. Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells. Methods Mol Biol. 2019;1899:87-101 pubmed 出版商
Trotta E, Bessette P, Silveria S, Ely L, Jude K, Le D, et al. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018;24:1005-1014 pubmed 出版商
Schmidt A, Marabita F, Kiani N, Gross C, Johansson H, Elias S, et al. Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. BMC Biol. 2018;16:47 pubmed 出版商
Shin J, Kim S, Noh J, Kim J, Kim H, Jeong K, et al. Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model. Allergy. 2018;73:1801-1811 pubmed 出版商
Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed 出版商
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed 出版商
Joshi R, Binai N, Marabita F, Sui Z, Altman A, Heck A, et al. Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells. Front Immunol. 2017;8:1163 pubmed 出版商
Cobb D, Kim O, Golden Mason L, Rosen H, Hahn Y. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2017;: pubmed 出版商
Saha C, Das M, Patil V, Stephen Victor E, Sharma M, Wymann S, et al. Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 Responses In Vitro Independent of Fc?RI and DC-SIGN. Front Immunol. 2017;8:275 pubmed 出版商
Hou T, Verma N, Wanders J, Kennedy A, Soskic B, Janman D, et al. Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations. Blood. 2017;129:1458-1468 pubmed 出版商
Elias S, Schmidt A, Kannan V, Andersson J, Tegner J. TGF-? Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol. 2016;7:603 pubmed 出版商
Stephen Victor E, Sharma V, Das M, Karnam A, Saha C, Lecerf M, et al. IL-1?, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis. Front Immunol. 2016;7:465 pubmed
Kovacsovics Bankowski M, Kelley T, Efimova O, Kim S, Wilson A, Swierczek S, et al. Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden. Exp Hematol Oncol. 2015;5:28 pubmed
Jones K, Ballesteros A, Mentink Kane M, Warren J, Rattila S, Malech H, et al. PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-?1 Pathway. PLoS ONE. 2016;11:e0158050 pubmed 出版商
Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed 出版商
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed 出版商
Schmidt A, Eriksson M, Shang M, Weyd H, Tegner J. Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS ONE. 2016;11:e0148474 pubmed 出版商
Patterson S, Pesenacker A, Wang A, Gillies J, Mojibian M, Morishita K, et al. T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. J Clin Invest. 2016;126:1039-51 pubmed 出版商
Pedroza Gonzalez A, Zhou G, Singh S, Boor P, Pan Q, Grunhagen D, et al. GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo. Oncoimmunology. 2015;4:e1051297 pubmed
Bending D, Giannakopoulou E, Lom H, Wedderburn L. Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression. J Immunol. 2015;195:5616-24 pubmed 出版商
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed 出版商
Schmitz Winnenthal F, Hohmann N, Niethammer A, Friedrich T, Lubenau H, Springer M, et al. Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: A randomized, placebo-controlled, phase 1 trial. Oncoimmunology. 2015;4:e1001217 pubmed
Tonsho M, Lee S, Aoyama A, Boskovic S, Nadazdin O, Capetta K, et al. Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism. Am J Transplant. 2015;15:2231-9 pubmed 出版商
Ye S, Li Z, Luo D, Huang B, Chen Y, Zhang X, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014;5:5439-52 pubmed
Magnusson M, Dahlén R, Strid H, Isaksson S, Simren M, Lasson A, et al. CD25 and TNF receptor II reflect early primary response to infliximab therapy in patients with ulcerative colitis. United European Gastroenterol J. 2013;1:467-76 pubmed 出版商
Ma G, Miao Q, Liu Y, Gao H, Lian J, Wang Y, et al. High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment. Br J Cancer. 2014;110:1552-60 pubmed 出版商
Renand A, Milpied P, Rossignol J, Bruneau J, Lemonnier F, Dussiot M, et al. Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs. PLoS ONE. 2013;8:e85589 pubmed 出版商
Schmidt H, Ge Y, Hartmann F, Conrad H, Klug F, Nittel S, et al. HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. Oncoimmunology. 2013;2:e24962 pubmed
Gooden M, Wiersma V, Samplonius D, Gerssen J, van Ginkel R, Nijman H, et al. Galectin-9 activates and expands human T-helper 1 cells. PLoS ONE. 2013;8:e65616 pubmed 出版商
Huen N, Pang A, Tucker J, Lee T, Vergati M, Jochems C, et al. Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer. Int J Cancer. 2013;133:373-82 pubmed 出版商
Lev A, Simon A, Trakhtenbrot L, Goldstein I, Nagar M, Stepensky P, et al. Characterizing T cells in SCID patients presenting with reactive or residual T lymphocytes. Clin Dev Immunol. 2012;2012:261470 pubmed 出版商
Gros A, Turcotte S, Wunderlich J, Ahmadzadeh M, Dudley M, Rosenberg S. Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma. Clin Cancer Res. 2012;18:5212-23 pubmed 出版商
Simonetta F, Lécuroux C, Girault I, Goujard C, Sinet M, Lambotte O, et al. Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection. J Infect Dis. 2012;205:1510-9 pubmed 出版商
Wongyanin P, Buranapraditkul S, Yoo D, Thanawongnuwech R, Roth J, Suradhat S. Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg). J Gen Virol. 2012;93:1236-46 pubmed 出版商
Bedoret D, Singh A, Shaw V, Hoyte E, Hamilton R, DeKruyff R, et al. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol. 2012;5:267-76 pubmed 出版商
Hughson A, Bromberg I, Johnson B, Quataert S, Jospe N, Fowell D. Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes. Diabetes. 2011;60:2125-33 pubmed 出版商
Cereda V, Vergati M, Huen N, di Bari M, Jochems C, Intrivici C, et al. Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells. Vaccine. 2011;29:4992-9 pubmed 出版商
Hovhannisyan Z, Treatman J, Littman D, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-65 pubmed 出版商
Vergati M, Cereda V, Madan R, Gulley J, Huen N, Rogers C, et al. Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination. Cancer Immunol Immunother. 2011;60:197-206 pubmed 出版商
Green A, Mattila J, Bigbee C, Bongers K, Lin P, Flynn J. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010;202:533-41 pubmed 出版商
Li W, Tenner Racz K, Racz P, Janowicz D, Fortney K, Katz B, et al. Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers. J Infect Dis. 2010;201:1839-48 pubmed 出版商
Poirier N, Azimzadeh A, Zhang T, Dilek N, Mary C, Nguyen B, et al. Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation. Sci Transl Med. 2010;2:17ra10 pubmed 出版商
Wang J, Huizinga T, Toes R. De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. J Immunol. 2009;183:4119-26 pubmed 出版商
Nagar M, Vernitsky H, Cohen Y, Dominissini D, Berkun Y, Rechavi G, et al. Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells. Int Immunol. 2008;20:1041-55 pubmed 出版商
Klatt N, Villinger F, Bostik P, Gordon S, Pereira L, Engram J, et al. Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys. J Clin Invest. 2008;118:2039-49 pubmed 出版商
Estes J, Gordon S, Zeng M, Chahroudi A, Dunham R, Staprans S, et al. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol. 2008;180:6798-807 pubmed
Lee H, Hong Y, Yun H, Kim Y, Kim J, Yoo W. Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus. Rheumatology (Oxford). 2008;47:789-94 pubmed 出版商
Passerini L, Allan S, Battaglia M, Di Nunzio S, Alstad A, Levings M, et al. STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol. 2008;20:421-31 pubmed 出版商
Wolf D, Wolf A, Rumpold H, Fiegl H, Zeimet A, Muller Holzner E, et al. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res. 2005;11:8326-31 pubmed
Ahmadzadeh M, Rosenberg S. IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood. 2006;107:2409-14 pubmed
Roncador G, Garcia J, Maestre L, Lucas E, Menarguez J, Ohshima K, et al. FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia. 2005;19:2247-53 pubmed
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Alvaro T, Lejeune M, Salvadó M, Bosch R, Garcia J, Jaén J, et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res. 2005;11:1467-73 pubmed
产品信息
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (236A/E7), APC, eBioscience™
目录# :
17-4777-42
规格 :
100试验
价格 :
美国389
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
Human, Non-human primate, Rhesus Monkey
应用 :
Flow Cytometry: 5 µL (0.125 µg)/test
物种 :
Human, Non-human primate, Rhesus Monkey
克隆 :
236A/E7
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.125 µg)/test
别名 :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国