产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience™
目录 :
17-7222-82
规格 :
100µg
价格 :
392.00美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
APC
克隆名称 :
IL22JOP
反应物种 :
人类, 小鼠, 猕猴
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 31
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 1:200; 图 8c
Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed 出版商
  • 流式细胞仪; 小鼠; 图 s4
Xiong H, Keith J, Samilo D, Carter R, Leiner I, Pamer E. Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance. Cell. 2016;165:679-89 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:100; 图 s4
Zanvit P, Konkel J, Jiao X, Kasagi S, Zhang D, Wu R, et al. Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nat Commun. 2015;6:8424 pubmed 出版商
  • 流式细胞仪; 人类; 图 3
Dyring Andersen B, Bonefeld C, Bzorek M, Løvendorf M, Lauritsen J, Skov L, et al. The Vitamin D Analogue Calcipotriol Reduces the Frequency of CD8+ IL-17+ T Cells in Psoriasis Lesions. Scand J Immunol. 2015;82:84-91 pubmed 出版商
Chaudhary O, Narayan V, Lelis F, Linz B, Watkins M, Veazey R, et al. Inhibition of p38 MAPK in combination with ART reduces SIV-induced immune activation and provides additional protection from immune system deterioration. PLoS Pathog. 2018;14:e1007268 pubmed 出版商
Metidji A, Omenetti S, Crotta S, Li Y, Nye E, Ross E, et al. The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity. Immunity. 2018;49:353-362.e5 pubmed 出版商
Emgård J, Kammoun H, García Cassani B, Chesne J, Parigi S, Jacob J, et al. Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation. Immunity. 2018;48:120-132.e8 pubmed 出版商
Ekmekciu I, von Klitzing E, Neumann C, Bacher P, Scheffold A, Bereswill S, et al. Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment. Front Microbiol. 2017;8:2430 pubmed 出版商
Affandi A, Silva Cardoso S, Garcia S, Leijten E, van Kempen T, Marut W, et al. CXCL4 is a novel inducer of human Th17 cells and correlates with IL-17 and IL-22 in psoriatic arthritis. Eur J Immunol. 2017;: pubmed 出版商
Seshadri S, Allan D, Carlyle J, Zenewicz L. Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling. PLoS Pathog. 2017;13:e1006690 pubmed 出版商
Kumar P, Kolls J. Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining. Bio Protoc. 2016;6: pubmed 出版商
Cibrian D, Sáiz M, de la Fuente H, Sánchez Díaz R, Moreno Gonzalo O, Jorge I, et al. CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis. Nat Immunol. 2016;17:985-96 pubmed 出版商
Ryan E, Micci L, Fromentin R, Paganini S, McGary C, Easley K, et al. Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques. PLoS Pathog. 2016;12:e1005412 pubmed 出版商
Okita Y, Shiono T, Yahagi A, Hamada S, Umemura M, Matsuzaki G. Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes. Infect Immun. 2016;84:573-9 pubmed 出版商
Micci L, Ryan E, Fromentin R, Bosinger S, Harper J, He T, et al. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J Clin Invest. 2015;125:4497-513 pubmed 出版商
Zhang W, Tian X, Mumtahana F, Jiao J, Zhang T, Croce K, et al. The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer. BMC Cancer. 2015;15:717 pubmed 出版商
Ortiz A, Klase Z, DiNapoli S, Vujkovic Cvijin I, Carmack K, Perkins M, et al. IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol. 2016;9:458-67 pubmed 出版商
Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, et al. Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy. J Immunol. 2015;194:5085-93 pubmed 出版商
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed 出版商
Graves A, Padilla M, Hokey D. OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory. Cytometry A. 2014;85:576-9 pubmed 出版商
Peng Y, Gao X, Yang J, Shekhar S, Wang S, Fan Y, et al. Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection. Mol Med. 2014;20:109-19 pubmed 出版商
Mielke L, Groom J, Rankin L, Seillet C, Masson F, Putoczki T, et al. TCF-1 controls ILC2 and NKp46+ROR?t+ innate lymphocyte differentiation and protection in intestinal inflammation. J Immunol. 2013;191:4383-91 pubmed 出版商
Russell S, Stefanska A, Kubica M, Horan R, Mantovani A, Garlanda C, et al. Toll IL-1R8/single Ig IL-1-related receptor regulates psoriasiform inflammation through direct inhibition of innate IL-17A expression by ?? T cells. J Immunol. 2013;191:3337-46 pubmed 出版商
Mielke L, Jones S, Raverdeau M, Higgs R, Stefanska A, Groom J, et al. Retinoic acid expression associates with enhanced IL-22 production by ?? T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210:1117-24 pubmed 出版商
Canary L, Vinton C, Morcock D, Pierce J, Estes J, Brenchley J, et al. Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques. J Immunol. 2013;190:2959-65 pubmed 出版商
Klatt N, Estes J, Sun X, Ortiz A, Barber J, Harris L, et al. Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal Immunol. 2012;5:646-57 pubmed 出版商
Kinnebrew M, Buffie C, Diehl G, Zenewicz L, Leiner I, Hohl T, et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012;36:276-87 pubmed 出版商
Harper E, Guo C, Rizzo H, Lillis J, Kurtz S, Skorcheva I, et al. Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol. 2009;129:2175-83 pubmed 出版商
Aujla S, Kolls J. IL-22: a critical mediator in mucosal host defense. J Mol Med (Berl). 2009;87:451-4 pubmed 出版商
Bettelli E, Korn T, Oukka M, Kuchroo V. Induction and effector functions of T(H)17 cells. Nature. 2008;453:1051-7 pubmed 出版商
Borst G, Rice S, Robinson W. Inpatient capillary glucose monitoring: a useful adjunct to the management of diabetes in community hospitals. J Ky Med Assoc. 1989;87:451-5 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-22 Monoclonal Antibody (IL22JOP), APC, eBioscience™
目录# :
17-7222-82
规格 :
100µg
价格(美元) :
392.00美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类, 小鼠, 猕猴
应用 :
Flow Cytometry: 0.25 µg/test
物种 :
人类, 小鼠, 猕猴
克隆 :
IL22JOP
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons. IL-22 is produced mainly by activated T cells and NK cells. In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10. IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2. IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29. Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes. IL-22 has been described as an effector cytokine of the Th17 lineage. Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin. IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated. The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes. IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors. IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses. IL-22 is upregulated in activated T cells. IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.25 µg/test
别名 :
Cytokine Zcyto18; EGK_03903; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-21; IL22; IL-22; Il22a; IL-22a; IL-D110; ILN; Iltif; IL-TIF; ILTIF alpha; IL-TIF alpha; ILTIFa; Interleukin; interleukin 10-related T cell-derived inducible factor; interleukin 22; Interleukin22; Interleukin-22; Interleukin-22a; RGD1561292; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国