产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IRF8 Monoclonal Antibody (V3GYWCH), APC, eBioscience
目录 :
17-9852-80
规格 :
25微克
价格 :
美国162
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
APC
克隆名称 :
V3GYWCH
反应物种 :
人类, 小鼠
应用 :
流式细胞仪, mass cytometry
更多信息或购买 :
文章摘录数: 14
出版应用/物种/样本/稀释 | 参考文献 |
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Cohen S, Smith N, McDougal C, Pepper M, Shah S, Yap G, et al. Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells. J Immunol. 2015;194:210-22 pubmed
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Tsujimura H, Tamura T, Ozato K. Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol. 2003;170:1131-5 pubmed
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Aliberti J, Schulz O, Pennington D, Tsujimura H, Reis E Sousa C, Ozato K, et al. Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood. 2003;101:305-10 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
IRF8 Monoclonal Antibody (V3GYWCH), APC, eBioscience
目录# :
17-9852-80
规格 :
25微克
价格 :
美国162
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Flow Cytometry: 0.25 µg/test
物种 :
人类, 小鼠
克隆 :
V3GYWCH
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 0.25 µg/test
别名 :
AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
更多信息或购买 :
公司信息
赛默飞世尔
产品浏览
- IRF8 Monoclonal Antibody (V3GYWCH), APC, eBioscience | 17-9852-82
- HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience | 17-9881-41
- HLA-DQ Monoclonal Antibody (SK10), APC, eBioscience | 17-9881-42
- CD31 (PECAM-1) Monoclonal Antibody (TLD-3A12), PE-Cyanine7, eBioscience
- CD32 Monoclonal Antibody (6C4 (CD32)), PE-Cyanine7, eBioscience | 25-0329-42
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