产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
c met原癌基因单克隆抗体(3D4)
目录 :
18-7366
规格 :
500微升
价格 :
美国482
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3D4
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 15
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 4a
Martin V, Chiriaco C, Modica C, Acquadro A, Cortese M, Galimi F, et al. Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours. Br J Cancer. 2019;120:527-536 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5
  • 免疫印迹; 小鼠; 图 4
Morena D, Maestro N, Bersani F, Forni P, Lingua M, Foglizzo V, et al. Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes. elife. 2016;5: pubmed 出版商
  • 免疫细胞化学; 人类; 表 2
Zhang T, Boominathan R, Foulk B, Rao C, Kemeny G, Strickler J, et al. Development of a Novel c-MET-Based CTC Detection Platform. Mol Cancer Res. 2016;14:539-47 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
  • 免疫印迹; 小鼠; 图 s1
Finisguerra V, Di Conza G, Di Matteo M, Serneels J, Costa S, Thompson A, et al. MET is required for the recruitment of anti-tumoural neutrophils. Nature. 2015;522:349-53 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Kim Y, Jin D, Lee B, Cho E, Han J, Shim Y, et al. RARβ2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung. Clin Epigenetics. 2015;7:32 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Mahadevan D, Theiss N, Morales C, Stejskal A, Cooke L, Zhu M, et al. Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST). Oncotarget. 2015;6:1954-66 pubmed
  • 免疫细胞化学; 人类; 1:100
Xie Y, Lu W, Liu S, Yang Q, Carver B, Li E, et al. Crosstalk between nuclear MET and SOX9/?-catenin correlates with castration-resistant prostate cancer. Mol Endocrinol. 2014;28:1629-39 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 4 ug/ml; 图 3
Straussman R, Morikawa T, Shee K, Barzily Rokni M, Qian Z, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487:500-4 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 3
Tretiakova M, Salama A, Karrison T, Ferguson M, Husain A, Vokes E, et al. MET and phosphorylated MET as potential biomarkers in lung cancer. J Environ Pathol Toxicol Oncol. 2011;30:341-54 pubmed
  • 免疫印迹; 人类; 图 3
Seiwert T, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, El Dinali M, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 2009;69:3021-31 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2a
Kong D, Song S, Kim D, Joo K, Yoo J, Koh J, et al. Prognostic significance of c-Met expression in glioblastomas. Cancer. 2009;115:140-8 pubmed 出版商
Munoz R, Hileeto D, Cruz Munoz W, Wood G, Xu P, Man S, et al. Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion. PLoS ONE. 2019;14:e0222580 pubmed 出版商
Schmitz K, Koeppen H, Binot E, Fassunke J, Künstlinger H, Ihle M, et al. MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas. PLoS ONE. 2015;10:e0120079 pubmed 出版商
Marchion D, Bicaku E, Xiong Y, Bou Zgheib N, Al Sawah E, Stickles X, et al. A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013;29:2011-8 pubmed 出版商
Tuynman J, Lagarde S, ten Kate F, Richel D, van Lanschot J. Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma. Br J Cancer. 2008;98:1102-8 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
c met原癌基因单克隆抗体(3D4)
目录# :
18-7366
规格 :
500微升
价格 :
美国482
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): Assay-dependent
物种 :
人类
克隆 :
3D4
抗体亚型 :
IgG2a
储存 :
4° C
描述 :
MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
免疫原 :
Synthetic peptide derived from cytoplasmic domain of human c-Met protein.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): Assay-dependent
别名 :
AI838057; AUTS9; bHLHe59; CG1705; CG1705-PA; CG1705-PB; cmet; c-met; c-met proto-oncogene; c-Met receptor tyrosine kinase; c-Met/HGF receptor; D249; DFNB97; Dmel CG1705; Dmel_CG1705; DmMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF receptor c-Met; HGF/SF receptor; HGFR; HGF-SF receptor; juvenile hormone resistance; met; met proto-oncogene; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; MET proto-oncogene, receptor tyrosine kinase; Met/Met1; Met; protein tyrosin kinase; methoprene tolerant; Methoprene-tolerant; Methoprene-tolerant protein; Met-PA; Met-PB; Mett; oncogene MET; Par4; Proto-oncogene c-Met; RCCP2; resistance (1) juvenile H; resistance to juvenile hormone; Rst(1)JH; sc MET; scatter factor receptor; SF receptor; soluble c met; tyrosine-protein kinase Met
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国