产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (236A/E7), PE-Cyanine7, eBioscience
目录 :
25-4777-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
PE/Cy7
克隆名称 :
236a/E7
反应物种 :
人类, 猕猴
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 28
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s7a
Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019;177:556-571.e16 pubmed 出版商
Arenas Luna V, Montesinos J, Cort xe9 s Morales V, Navarro Betancourt J, Peralta Ildefonso J, Cisneros B, et al. In Vitro Evidence of Differential Immunoregulatory Response between MDA-MB-231 and BT-474 Breast Cancer Cells Induced by Bone Marrow-Derived Mesenchymal Stromal Cells Conditioned Medium. Curr Issues Mol Biol. 2022;45:268-285 pubmed 出版商
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition). Eur J Immunol. 2021;51:2708-3145 pubmed 出版商
Geuijen C, Tacken P, Wang L, Klooster R, Van Loo P, Zhou J, et al. A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade. Nat Commun. 2021;12:4445 pubmed 出版商
Kuri Cervantes L, Pampena M, Betts M. Phenotypic Characterization of SLex+ and CLA+ CD4+ T Cells. STAR Protoc. 2020;1:100154 pubmed 出版商
Colomb F, Giron L, Kuri Cervantes L, Adeniji O, Ma T, Dweep H, et al. Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Cell Rep. 2020;32:107991 pubmed 出版商
Freeman Z, Nirschl T, Hovelson D, Johnston R, Engelhardt J, Selby M, et al. A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. J Clin Invest. 2020;130:1405-1416 pubmed 出版商
Van de Geer A, Cuadrado E, Slot M, Van Bruggen R, Amsen D, Kuijpers T. Regulatory T cell features in chronic granulomatous disease. Clin Exp Immunol. 2019;197:222-229 pubmed 出版商
Barry K, Hsu J, Broz M, Cueto F, Binnewies M, Combes A, et al. A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments. Nat Med. 2018;24:1178-1191 pubmed 出版商
Cuadrado E, van den Biggelaar M, de Kivit S, Chen Y, Slot M, Doubal I, et al. Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity. Immunity. 2018;48:1046-1059.e6 pubmed 出版商
Terranova Barberio M, Thomas S, Ali N, Pawlowska N, Park J, Krings G, et al. HDAC inhibition potentiates immunotherapy in triple negative breast cancer. Oncotarget. 2017;8:114156-114172 pubmed 出版商
Kishore M, Cheung K, Fu H, Bonacina F, Wang G, Coe D, et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47:875-889.e10 pubmed 出版商
Zanin Zhorov A, Weiss J, Trzeciak A, Chen W, Zhang J, Nyuydzefe M, et al. Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10. J Immunol. 2017;198:3809-3814 pubmed 出版商
Su S, Liao J, Liu J, Huang D, He C, Chen F, et al. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017;27:461-482 pubmed 出版商
Kovacsovics Bankowski M, Kelley T, Efimova O, Kim S, Wilson A, Swierczek S, et al. Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden. Exp Hematol Oncol. 2015;5:28 pubmed
Liang D, Hou Y, Luo L, Ao L. Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. Int J Mol Med. 2016;38:131-8 pubmed 出版商
Macdonald K, Hoeppli R, Huang Q, Gillies J, Luciani D, Orban P, et al. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest. 2016;126:1413-24 pubmed 出版商
Miles B, Miller S, Folkvord J, Kimball A, Chamanian M, Meditz A, et al. Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection. Nat Commun. 2015;6:8608 pubmed 出版商
Ye S, Li Z, Luo D, Huang B, Chen Y, Zhang X, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014;5:5439-52 pubmed
Roselli M, Cereda V, di Bari M, Formica V, Spila A, Jochems C, et al. Effects of conventional therapeutic interventions on the number and function of regulatory T cells. Oncoimmunology. 2013;2:e27025 pubmed
Schmidt H, Ge Y, Hartmann F, Conrad H, Klug F, Nittel S, et al. HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients. Oncoimmunology. 2013;2:e24962 pubmed
Green A, Mattila J, Bigbee C, Bongers K, Lin P, Flynn J. CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010;202:533-41 pubmed 出版商
Estes J, Gordon S, Zeng M, Chahroudi A, Dunham R, Staprans S, et al. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol. 2008;180:6798-807 pubmed
Wolf D, Wolf A, Rumpold H, Fiegl H, Zeimet A, Muller Holzner E, et al. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res. 2005;11:8326-31 pubmed
Ahmadzadeh M, Rosenberg S. IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood. 2006;107:2409-14 pubmed
Roncador G, Garcia J, Maestre L, Lucas E, Menarguez J, Ohshima K, et al. FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma. Leukemia. 2005;19:2247-53 pubmed
Roncador G, Brown P, Maestre L, Hue S, Martinez Torrecuadrada J, Ling K, et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol. 2005;35:1681-91 pubmed
Alvaro T, Lejeune M, Salvadó M, Bosch R, Garcia J, Jaén J, et al. Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res. 2005;11:1467-73 pubmed
产品信息
产品类型 :
抗体
产品名称 :
FOXP3 Monoclonal Antibody (236A/E7), PE-Cyanine7, eBioscience
目录# :
25-4777-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
Human, Non-human primate, Rhesus Monkey
应用 :
Flow Cytometry: 5 µL (0.125 µg)/test
物种 :
Human, Non-human primate, Rhesus Monkey
克隆 :
236A/E7
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.125 µg)/test
别名 :
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国