产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), PE-Cyanine7, eBioscience™
目录 :
25-9924-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
PE/Cy7
克隆名称 :
MTS510
反应物种 :
小鼠
应用 :
流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 79
参考文献
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Arranz A, Juarranz Y, Leceta J, Gomariz R, Martinez C. VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4. Peptides. 2008;29:948-56 pubmed 出版商
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Ukai T, Yumoto H, Gibson F, Genco C. Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production. Infect Immun. 2008;76:812-9 pubmed
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Shu S, Lian Z, Chuang Y, Yang G, Moritoki Y, Comstock S, et al. The role of CD11c(+) hepatic dendritic cells in the induction of innate immune responses. Clin Exp Immunol. 2007;149:335-43 pubmed
Liu X, Ukai T, Yumoto H, Davey M, Goswami S, Gibson F, et al. Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids. Atherosclerosis. 2008;196:146-54 pubmed
Eguchi M, Sekiya Y, Suzuki M, Yamamoto T, Matsui H. An oral Salmonella vaccine promotes the down-regulation of cell surface Toll-like receptor 4 (TLR4) and TLR2 expression in mice. FEMS Immunol Med Microbiol. 2007;50:300-8 pubmed
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Lin Y, Xie M, Chen Y, Di J, Zeng Y. Preterm delivery induced by LPS in syngeneically impregnated BALB/c and NOD/SCID mice. J Reprod Immunol. 2006;71:87-101 pubmed
Kajita E, Nishiya T, Miwa S. The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3. Biochem Biophys Res Commun. 2006;343:578-84 pubmed
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Sun D, Chen D, Du B, Pan J. Heat shock response inhibits NF-kappaB activation and cytokine production in murine Kupffer cells. J Surg Res. 2005;129:114-21 pubmed
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Qi H, Shelhamer J. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2005;280:38969-75 pubmed
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Nagaoka K, Takahara K, Tanaka K, Yoshida H, Steinman R, Saitoh S, et al. Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria. Int Immunol. 2005;17:827-36 pubmed
Mu H, Pennock N, Humphreys J, Kirschning C, Cole B. Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction. Cell Microbiol. 2005;7:789-97 pubmed
Gomariz R, Arranz A, Abad C, Torroba M, Martinez C, Rosignoli F, et al. Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP. J Leukoc Biol. 2005;78:491-502 pubmed
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Shimura H, Nitahara A, Ito A, Tomiyama K, Ito M, Kawai K. Up-regulation of cell surface Toll-like receptor 4-MD2 expression on dendritic epidermal T cells after the emigration from epidermis during cutaneous inflammation. J Dermatol Sci. 2005;37:101-10 pubmed
Chelvarajan R, Collins S, Van Willigen J, Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005;77:503-12 pubmed
Ortega Cava C, Ishihara S, Rumi M, Kawashima K, Ishimura N, Kazumori H, et al. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol. 2003;170:3977-85 pubmed
Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt P, Takeda K, et al. Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol. 2000;165:7096-101 pubmed
Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, et al. Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol. 2000;164:3471-5 pubmed
产品信息
产品类型 :
抗体
产品名称 :
TLR4/MD-2 Complex Monoclonal Antibody (MTS510), PE-Cyanine7, eBioscience™
目录# :
25-9924-82
规格 :
100微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: 2 µg/test
物种 :
小鼠
克隆 :
MTS510
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 2 µg/test
别名 :
ARMD10; CD284; Esop1; ESOP-1; hToll; lipopolysaccharide response; Lps; Ly87; Ly96; Ly-96; Lymphocyte antigen 96; Md2; MD-2; myeloid differentiation factor-2; myeloid differentiation protein-2; protein MD-2; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; Toll-like receptor 4
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国