产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD184 (CXCR4) Monoclonal Antibody (12G5), PE-Cyanine7, eBioscience™
目录 :
25-9999-42
规格 :
100试验
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
PE/Cy7
克隆名称 :
12G5
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 33
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s1b
Ye S, Li Z, Luo D, Huang B, Chen Y, Zhang X, et al. Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget. 2014;5:5439-52 pubmed
Berning P, Schaefer C, Clemens D, Korsching E, Dirksen U, Potratz J. The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling. Cell Commun Signal. 2018;16:21 pubmed 出版商
Topel M, Hayek S, Ko Y, Sandesara P, Samman Tahhan A, Hesaroieh I, et al. Sex Differences in Circulating Progenitor Cells. J Am Heart Assoc. 2017;6: pubmed 出版商
Webber B, Osborn M, McElroy A, Twaroski K, Lonetree C, Defeo A, et al. CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa. NPJ Regen Med. 2016;1: pubmed 出版商
Al Mheid I, Hayek S, Ko Y, Akbik F, Li Q, Ghasemzadeh N, et al. Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors. Circ Res. 2016;119:801-9 pubmed 出版商
Berger R, Sun Y, Kulik M, Lee J, Nairn A, Moremen K, et al. ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells. Stem Cells. 2016;34:1742-52 pubmed 出版商
Hajjar I, Goldstein F, Waller E, Moss L, Quyyumi A. Circulating Progenitor Cells is Linked to Cognitive Decline in Healthy Adults. Am J Med Sci. 2016;351:147-52 pubmed 出版商
Sison E, Magoon D, Li L, Annesley C, Rau R, Small D, et al. Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition. Oncotarget. 2014;5:8947-58 pubmed
Patel R, Li Q, Ghasemzadeh N, Eapen D, Moss L, Janjua A, et al. Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease. Circ Res. 2015;116:289-297 pubmed 出版商
Poole J, Mavromatis K, Binongo J, Khan A, Li Q, Khayata M, et al. Effect of progenitor cell mobilization with granulocyte-macrophage colony-stimulating factor in patients with peripheral artery disease: a randomized clinical trial. JAMA. 2013;310:2631-9 pubmed 出版商
Cimato T, Palka B, Lang J, Young R. LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis. PLoS ONE. 2013;8:e73861 pubmed 出版商
Peters J, Koenen H, Fasse E, Tijssen H, Ijzermans J, Groenen P, et al. Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells. Blood. 2013;122:2213-23 pubmed 出版商
Turaç G, Hindley C, Thomas R, Davis J, Deleidi M, Gasser T, et al. Combined flow cytometric analysis of surface and intracellular antigens reveals surface molecule markers of human neuropoiesis. PLoS ONE. 2013;8:e68519 pubmed 出版商
Cany J, van der Waart A, Tordoir M, Franssen G, Hangalapura B, De Vries J, et al. Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice. PLoS ONE. 2013;8:e64384 pubmed 出版商
Rieber N, Brand A, Hector A, Graepler Mainka U, Ost M, Schäfer I, et al. Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease. J Immunol. 2013;190:1276-84 pubmed 出版商
Frick S, Bacher N, Baier G, Mailänder V, Landfester K, Steinbrink K. Functionalized polystyrene nanoparticles trigger human dendritic cell maturation resulting in enhanced CD4+ T cell activation. Macromol Biosci. 2012;12:1637-47 pubmed 出版商
Ofori Acquah S, Buchanan I, Osunkwo I, Manlove Simmons J, Lawal F, Quarshie A, et al. Elevated circulating angiogenic progenitors and white blood cells are associated with hypoxia-inducible angiogenic growth factors in children with sickle cell disease. Anemia. 2012;2012:156598 pubmed 出版商
Danova Alt R, Heider A, Egger D, Cross M, Alt R. Very small embryonic-like stem cells purified from umbilical cord blood lack stem cell characteristics. PLoS ONE. 2012;7:e34899 pubmed 出版商
Kroenke M, Eto D, Locci M, Cho M, Davidson T, Haddad E, et al. Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol. 2012;188:3734-44 pubmed 出版商
Prabakar K, Dominguez Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, et al. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells. Cell Transplant. 2012;21:1321-39 pubmed 出版商
Kean L, Sen S, Onabajo O, Singh K, Robertson J, Stempora L, et al. Significant mobilization of both conventional and regulatory T cells with AMD3100. Blood. 2011;118:6580-90 pubmed 出版商
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Rasmussen T, Andersen T, Hvid M, Hetland M, Hørslev Petersen K, Stengaard Pedersen K, et al. Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol. 2010;37:2014-20 pubmed 出版商
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Mikami S, Nakase H, Yamamoto S, Takeda Y, Yoshino T, Kasahara K, et al. Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther. 2008;327:383-92 pubmed 出版商
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Li G, Basu S, Han M, Kim Y, Broxmeyer H. Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte-derived dendritic cells to CCL19 and CXCL12. Blood. 2007;109:3173-6 pubmed
Zhang C, Cui G, Liu F, Wu Q, Chen Y. Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro. Acta Pharmacol Sin. 2006;27:1438-46 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
CD184 (CXCR4) Monoclonal Antibody (12G5), PE-Cyanine7, eBioscience™
目录# :
25-9999-42
规格 :
100试验
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.25 µg)/test
物种 :
人类
克隆 :
12G5
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.25 µg)/test
别名 :
b2b220Clo; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD antigen CD184; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor; chemokine receptor (LCR1); chemokine receptor 4; chemokine receptor CXCR4; Cmkar4; CXC; CXC chemokine receptor; C-X-C chemokine receptor type 4; CXC motif chemokine; C-X-C motif chemokine receptor 4; CXCR4; CXC-R4; CXCR-4; D2S201E; FB22; Fusin; HM89; HSY3RR; HUMSTR; LAP3; LAP-3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; PB-CKR; PBSF/SDF-1; pre-B-cell-derived chemokine receptor; SDF-1 receptor; Sdf1r; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM; WHIMS
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国