产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
HPV类型16 E7单克隆抗体(8C9)
目录 :
28-0006
规格 :
50微克
价格 :
411美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
8C9
反应物种 :
人乳头状瘤病毒, 小鼠, 人乳头状瘤病毒类型16
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人乳头状瘤病毒; 图 1
Hobbs R, Batazzi A, Han M, Coulombe P. Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo. Oncogene. 2016;35:5653-5662 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 s1g
  • 免疫印迹; 小鼠; 图 s1g
Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed 出版商
  • 免疫沉淀; 人乳头状瘤病毒
Dichamp I, Seite P, Agius G, Barbarin A, Beby Defaux A. Human papillomavirus 16 oncoprotein E7 stimulates UBF1-mediated rDNA gene transcription, inhibiting a p53-independent activity of p14ARF. PLoS ONE. 2014;9:e96136 pubmed 出版商
  • 免疫印迹; 人乳头状瘤病毒; 1:200
Pang C, Toh S, He P, Teissier S, Ben Khalifa Y, Xue Y, et al. A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c). Oncogene. 2014;33:4039-49 pubmed 出版商
  • 免疫细胞化学; 人乳头状瘤病毒类型16
  • 免疫印迹; 人乳头状瘤病毒类型16
Laurson J, Raj K. Localisation of human papillomavirus 16 E7 oncoprotein changes with cell confluence. PLoS ONE. 2011;6:e21501 pubmed 出版商
  • 免疫细胞化学; 人乳头状瘤病毒; 1:25; 图 4
Sulg M, Kirjavainen A, Pajusola K, Bueler H, Ylikoski J, Laiho M, et al. Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction. J Neurochem. 2010;112:1513-26 pubmed 出版商
Suksanpaisan L, Xu R, Tesfay M, Bomidi C, Hamm S, Vandergaast R, et al. Preclinical Development of Oncolytic Immunovirotherapy for Treatment of HPVPOS Cancers. Mol Ther Oncolytics. 2018;10:1-13 pubmed 出版商
Jiang R, Wang J, Peng S, Huang T, Wang C, Cannella F, et al. Spontaneous and Vaccine-Induced Clearance of Mus Musculus Papillomavirus 1 Infection. J Virol. 2017;91: pubmed 出版商
Kayama K, Watanabe S, Takafuji T, Tsuji T, Hironaka K, Matsumoto M, et al. GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis. EMBO Rep. 2017;18:123-137 pubmed 出版商
Strickland S, Vande Pol S. The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. J Virol. 2016;90:5611-5621 pubmed 出版商
Fan X, Liu Y, Heilman S, Chen J. Human papillomavirus E7 induces rereplication in response to DNA damage. J Virol. 2013;87:1200-10 pubmed 出版商
Grasso F, Negri D, Mochi S, Rossi A, Cesolini A, Giovannelli A, et al. Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein. Int J Cancer. 2013;132:335-44 pubmed 出版商
Isaacson Wechsler E, Wang Q, Roberts I, Pagliarulo E, Jackson D, Untersperger C, et al. Reconstruction of human papillomavirus type 16-mediated early-stage neoplasia implicates E6/E7 deregulation and the loss of contact inhibition in neoplastic progression. J Virol. 2012;86:6358-64 pubmed 出版商
Bodily J, Mehta K, Cruz L, Meyers C, Laimins L. The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. J Virol. 2011;85:8852-62 pubmed 出版商
Handa K, Yugawa T, Narisawa Saito M, Ohno S, Fujita M, Kiyono T. E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein. J Virol. 2007;81:1379-89 pubmed
Berger K, Barriga F, Lace M, Turek L, Zamba G, Domann F, et al. Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras. Virology. 2006;356:68-78 pubmed
Simonson S, Difilippantonio M, Lambert P. Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential. Cancer Res. 2005;65:8266-73 pubmed
Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne M, et al. Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways. Mol Cancer Res. 2003;1:195-206 pubmed
Debnath J, Mills K, Collins N, Reginato M, Muthuswamy S, Brugge J. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 2002;111:29-40 pubmed
Thompson D, Zacny V, Belinsky G, Classon M, Jones D, Schlegel R, et al. The HPV E7 oncoprotein inhibits tumor necrosis factor alpha-mediated apoptosis in normal human fibroblasts. Oncogene. 2001;20:3629-40 pubmed
Loeuillet C, Douay L, Herve P, Chalmers D. Preservation of the myofibroblastic phenotype of human papilloma virus 16 E6/E7 immortalized human bone marrow cells using the lineage limited alpha-smooth muscle actin promoter. Cell Growth Differ. 2001;12:233-42 pubmed
产品信息
产品类型 :
抗体
产品名称 :
HPV类型16 E7单克隆抗体(8C9)
目录# :
28-0006
规格 :
50微克
价格 :
411美元
克隆性 :
单克隆
纯度 :
HPLC
宿主 :
小鼠
反应物种 :
病毒
应用 :
Immunohistochemistry (Paraffin): 1:2, Immunoprecipitation: 1:10, Western Blot: 1:100
物种 :
病毒
克隆 :
8C9
抗体亚型 :
IgG1
储存 :
4° C
描述 :
The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.
免疫原 :
Bacterially derived fusion protein containing the human papillomavirus tp 16 early protein E7 open reading frame.
格式 :
冻干
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:2, Immunoprecipitation: 1:10, Western Blot: 1:100
别名 :
HPV 16-E7;HPV16E7;人乳头状瘤病毒
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国