产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NMDAR2B单克隆抗体(B3-13B11)
目录 :
32-0700
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
B3-13B11
反应物种 :
人类, 大鼠, 犬
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 3
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
O Donnell L, Agrawal A, Jordan Sciutto K, Dichter M, Lynch D, Kolson D. Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. J Neurosci. 2006;26:981-90 pubmed
| |
Varney M, Jachec C, Deal C, Hess S, Daggett L, Skvoretz R, et al. Stable expression and characterization of recombinant human heteromeric N-methyl-D-aspartate receptor subtypes NMDAR1A/2A and NMDAR1A/2B in mammalian cells. J Pharmacol Exp Ther. 1996;279:367-78 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
NMDAR2B单克隆抗体(B3-13B11)
目录# :
32-0700
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Canine, Human, Non-human primate, Rat
应用 :
ELISA: 1.0-5 µg/mL, Immunohistochemistry (Frozen): 5-10 µg/mL, Western Blot: 1-5 µg/mL
物种 :
Canine, Human, Non-human primate, Rat
克隆 :
B3-13B11
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
免疫原 :
NMDA受体2B融合蛋白
格式 :
液体
应用w/稀释 :
ELISA: 1.0-5 µg/mL, Immunohistochemistry (Frozen): 5-10 µg/mL, Western Blot: 1-5 µg/mL
别名 :
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
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公司信息
赛默飞世尔