产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
周期蛋白E单克隆抗体(HE172)
目录 :
32-1500
规格 :
200微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HE172
反应物种 :
人类
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 5
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4
Podmirseg S, Jäkel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed 出版商
Christensen H, Trotter C, Hickman M, Edmunds W. Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in England: modelling study. BMJ. 2014;349:g5725 pubmed 出版商
Mehdipour P, Kheirollahi M, Mehrazin M, Kamalian N, Atri M. Evolutionary hypothesis of telomere length in primary breast cancer and brain tumour patients: a tracer for genomic-tumour heterogeneity and instability. Cell Biol Int. 2011;35:915-25 pubmed 出版商
Tudzarova S, Trotter M, Wollenschlaeger A, Mulvey C, Godovac Zimmermann J, Williams G, et al. Molecular architecture of the DNA replication origin activation checkpoint. EMBO J. 2010;29:3381-94 pubmed 出版商
Zhou D, Conrad C, Xia F, Park J, Payer B, Yin Y, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009;16:425-38 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
周期蛋白E单克隆抗体(HE172)
目录# :
32-1500
规格 :
200微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
Gel Shift: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunoprecipitation: 1 µg, Western Blot: 1-2 µg/mL
物种 :
人类
克隆 :
HE172
抗体亚型 :
IgG2b, kappa
储存 :
-20°C
描述 :
Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
免疫原 :
This antibody was prepared against full-length, recombinant, human cyclin E protein.
格式 :
液体
应用w/稀释 :
Gel Shift: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunoprecipitation: 1 µg, Western Blot: 1-2 µg/mL
别名 :
AW538188; CCNE; Ccne1; CycE1; CYCLE; cyclin E; cyclin E1; cyclin Es; cyclin Et; E-S; G1/S-specific cyclin-E1; pCCNE1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国