产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
硝基酪氨酸单克隆抗体(HM11)
目录 :
32-1900
规格 :
100微克
价格 :
美国449.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HM11
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 21
| 参考文献 |
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Vaninetti N, Geldenhuys L, Porter G, Risch H, Hainaut P, Guernsey D, et al. Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Mol Carcinog. 2008;47:275-85 pubmed
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Yeo M, Kim D, Cho S, Hong H. Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27. Dig Dis Sci. 2008;53:606-13 pubmed
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Olmos A, Giner R, Recio M, Rios J, Cerdá Nicolás J, Máñez S. Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity. Br J Pharmacol. 2007;152:366-73 pubmed
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Wada K, Nakajima A, Takahashi H, Yoneda M, Fujisawa N, Ohsawa E, et al. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2004;287:G452-8 pubmed
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Cho W, Chae C. Evidence of nitric oxide synthase 2 activity in swine naturally infected with Actinobacillus pleuropneumoniae. Vet Pathol. 2003;40:276-82 pubmed
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Irie Y, Saeki M, Kamisaki Y, Martin E, Murad F. Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins. Proc Natl Acad Sci U S A. 2003;100:5634-9 pubmed
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Montalto M, Hart M, Jordan J, Wada K, Stahl G. Role for complement in mediating intestinal nitric oxide synthase-2 and superoxide dismutase expression. Am J Physiol Gastrointest Liver Physiol. 2003;285:G197-206 pubmed
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Newman D, Hoffman S, Kotamraju S, Zhao T, Wakim B, Kalyanaraman B, et al. Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. Biochem Biophys Res Commun. 2002;296:1171-9 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
硝基酪氨酸单克隆抗体(HM11)
目录# :
32-1900
规格 :
100微克
价格 :
美国449.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
化学品
应用 :
Immunohistochemistry: 1-2 µg/mL, Western Blot: 1-2 µg/mL
物种 :
化学品
克隆 :
HM11
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Nitrotyrosine is a relatively stable product formed from various reaction pathways. Perhaps most notable is the reaction of peroxynitrite (formed from superoxide and nitric oxide (NO) radicals) with tyrosine. As a strong oxidant and nitrating agent, peroxynitrite mediates tyrosine nitration reactions on proteins resulting in inactivation of certain housekeeping enzymes (e. g., alpha1-antiproteinase) as well as endogenous antioxidant enzymes such as catalase and superoxide dismutase (SOD). Nitrotyrosine has been identified as an indicator of cell damage and inflammation, as well as of the production of NO. It is believed that measuring the concentration of nitrotyrosine will serve as a marker for damage caused by NO in the cell. Nitrotyrosine has been implicated in the pathogenesis of several inflammatory, infectious, and degenerative human diseases, such as Alzheimer's and Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury. At the protein level, tyrosine nitration can lead to loss or alteration of protein function, as demonstrated for the oncogenic protein p53 and the mitochondrial protein, manganese-dependent superoxide dismutase (MnSOD).
免疫原 :
Nitrotyrosine attached to a carrier protein
格式 :
液体
应用w/稀释 :
Immunohistochemistry: 1-2 µg/mL, Western Blot: 1-2 µg/mL
别名 :
Nitro-tyrosine
更多信息或购买 :
公司信息
赛默飞世尔