产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1)
目录 :
32-9400
规格 :
100微克
价格 :
美国419.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3E2C1
反应物种 :
African green monkey, 罗非鱼, southern flounder, 人类, 小鼠, 大鼠, , pigs , 家羊, 非洲爪蛙, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 219
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:5000; 图 6b
Tabariès S, Annis M, Lazaris A, Petrillo S, Huxham J, Abdellatif A, et al. Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern. Commun Biol. 2021;4:657 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 s7c
Wijshake T, Zou Z, Chen B, Zhong L, Xiao G, Xie Y, et al. Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 3c
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed 出版商
  • 免疫细胞化学; 犬; 图 1
  • 免疫印迹; 犬; 图 1
Tokuda S, Hirai T, Furuse M. Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells. PLoS ONE. 2017;12:e0182521 pubmed 出版商
  • 免疫组化-石蜡切片; 犬; 1.2 ug/ml; 图 4e
  • 免疫印迹; 犬; 图 2
Yokoyama N, Ohta H, Kagawa Y, Leela Arporn R, Dermlim A, Nisa K, et al. Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps. J Vet Med Sci. 2017;79:456-463 pubmed 出版商
  • 免疫细胞化学; domestic rabbit; 1:50; 图 6a
Martínez Rendón J, Sánchez Guzmán E, Rueda A, González J, Gulias Cañizo R, Aquino Jarquin G, et al. TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium. J Cell Physiol. 2017;232:1794-1807 pubmed 出版商
  • 免疫细胞化学; 人类; 1:700; 图 1b
Niehues H, Schalkwijk J, van Vlijmen Willems I, Rodijk Olthuis D, van Rossum M, Wladykowski E, et al. Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function. J Allergy Clin Immunol. 2017;139:1979-1981.e13 pubmed 出版商
  • 免疫细胞化学; 犬; 1:200; 表 5
Hammer S, Becker A, Rateitschak K, Mohr A, Lüder Ripoli F, Hennecke S, et al. Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines. Int J Mol Sci. 2016;17: pubmed
  • 免疫组化-石蜡切片; 犬; 1:200; 图 2c
  • 免疫印迹; 犬; 1:500; 图 1g
Ahn C, Shin D, Lee D, Kang S, Seok J, Kang H, et al. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016;14:3697-703 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Yuki T, Tobiishi M, Kusaka Kikushima A, Ota Y, Tokura Y. Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17. PLoS ONE. 2016;11:e0161759 pubmed 出版商
  • 免疫细胞化学; 犬; 1:200; 图 5
  • 免疫印迹; 犬; 1:1000; 图 3a
Ronaghan N, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, et al. The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction. Am J Physiol Gastrointest Liver Physiol. 2016;311:G466-79 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3e
Ocón B, Aranda C, Gámez Belmonte R, Suárez M, Zarzuelo A, Martinez Augustin O, et al. The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice. Biochem Pharmacol. 2016;116:73-88 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:50; 图 4
  • 免疫印迹; 大鼠; 1:500; 图 2
Xu S, Xue X, You K, Fu J. Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown. Respir Res. 2016;17:50 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Thakkar A, Wang B, Picon Ruiz M, Buchwald P, Ince T. Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast Cancer Res Treat. 2016;157:77-90 pubmed 出版商
  • 免疫印迹; pigs ; 1:1000; 图 7
Ling K, Wan M, El Nezami H, Wang M. Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation. Chem Res Toxicol. 2016;29:823-33 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Böhringer M, Pohlers S, Schulze S, Albrecht Eckardt D, Piegsa J, Weber M, et al. Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1. Cell Microbiol. 2016;18:889-904 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
  • 免疫印迹; 人类; 1:375; 图 2a
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed 出版商
  • 免疫印迹; 人类; 0.5 ug/ml
Smith N, Hinley J, Varley C, Eardley I, Trejdosiewicz L, Southgate J. The human urothelial tight junction: claudin 3 and the ZO-1α+ switch. Bladder (San Franc). 2015;2:e9 pubmed
  • 免疫组化; 大鼠
Liu W, Zhong Z, Cao L, Li H, Zhang T, Lin W. Paclitaxel-induced lung injury and its amelioration by parecoxib sodium. Sci Rep. 2015;5:12977 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, et al. Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. Hum Pathol. 2015;46:1257-66 pubmed 出版商
  • 免疫印迹; 人类; 1:167
Todd M, Petty H, King J, Piana Marshall B, Sheller R, Cuevas M. Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines. Oncol Lett. 2015;10:156-162 pubmed
  • 免疫组化; 大鼠; 1:100; 图 2
  • 免疫印迹; 大鼠; 1:1000; 图 2
Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed 出版商
  • 免疫组化; 人类; 图 3
Bhagirath D, Zhao X, West W, Qiu F, Band H, Band V. Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes. Oncotarget. 2015;6:9018-30 pubmed
  • 免疫细胞化学; 犬
  • 免疫印迹; 犬
Tokuda S, Furuse M. Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS ONE. 2015;10:e0119869 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Watari A, Hashegawa M, Yagi K, Kondoh M. Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. Eur J Pharm Biopharm. 2015;89:232-8 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 3
Qiao X, Roth I, Féraille E, Hasler U. Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle. 2014;13:3059-75 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S. Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes. Biochem Biophys Res Commun. 2014;455:205-11 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100
Jiwa L, van Diest P, Hoefnagel L, Wesseling J, Wesseling P, Moelans C. Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases. BMC Cancer. 2014;14:864 pubmed 出版商
  • 免疫组化-冰冻切片; 非洲爪蛙; 图 3
Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed 出版商
  • 免疫印迹; 人类
Lejeune M, Moreau F, Chadee K. Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4. PLoS ONE. 2014;9:e113270 pubmed 出版商
  • 免疫组化; 人类; 1:50; 图 1
Ma F, Ding X, Fan Y, Ying J, Zheng S, Lu N, et al. A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer. PLoS ONE. 2014;9:e112765 pubmed 出版商
  • 免疫印迹; 人类
Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed 出版商
  • 免疫印迹; 家羊; 1:500
Tao S, Duanmu Y, Dong H, Tian J, Ni Y, Zhao R. A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats. BMC Vet Res. 2014;10:235 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类; 1:500
Afshar Moghaddam N, Heidarpour M, Dashti S. Diagnostic value of claudin-4 marker in pleural and peritoneal effusion cytology: Does it differentiate between metastatic adenocarcinoma and reactive mesothelial cells?. Adv Biomed Res. 2014;3:161 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Kim C, Galloway J, Lee K, Searson P. Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers. Bioconjug Chem. 2014;25:1893-901 pubmed 出版商
  • 免疫细胞化学; 犬
  • 免疫印迹; 犬
Tokuda S, Higashi T, Furuse M. ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS ONE. 2014;9:e104994 pubmed 出版商
  • 免疫细胞化学; 人类
Gusti V, Bennett K, Lo D. CD137 signaling enhances tight junction resistance in intestinal epithelial cells. Physiol Rep. 2014;2: pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1d
Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, et al. Claudins as prognostic factors for renal cell cancer. Anticancer Res. 2014;34:4181-7 pubmed
  • 免疫印迹; 犬; 图 1
Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim S, Tamura Y, et al. Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. Am J Vet Res. 2014;75:746-51 pubmed 出版商
  • 免疫细胞化学; 犬; 1:100; 图 4
  • 免疫细胞化学; 人类; 1:100; 图 4
Glotfelty L, Zahs A, Hodges K, Shan K, Alto N, Hecht G. Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration. Cell Microbiol. 2014;16:1767-83 pubmed 出版商
  • 免疫细胞化学; African green monkey
  • 免疫印迹; African green monkey
García Hernández V, Flores Maldonado C, Rincon Heredia R, Verdejo Torres O, Bonilla Delgado J, Meneses Morales I, et al. EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells. J Cell Physiol. 2015;230:105-15 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:250
Ordonez N, Sahin A. Diagnostic utility of immunohistochemistry in distinguishing between epithelioid pleural mesotheliomas and breast carcinomas: a comparative study. Hum Pathol. 2014;45:1529-40 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:200
  • 免疫印迹; 大鼠; 1:400
Grosse B, Degrouard J, Jaillard D, Cassio D. Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins. Tissue Barriers. 2013;1:e25210 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100; 图 2
Somorácz A, Korompay A, Törzsök P, Patonai A, Erdélyi Belle B, Lotz G, et al. Tricellulin expression and its prognostic significance in primary liver carcinomas. Pathol Oncol Res. 2014;20:755-64 pubmed 出版商
  • 免疫组化; 人类
Melchor L, Molyneux G, Mackay A, Magnay F, Atienza M, Kendrick H, et al. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol. 2014;233:124-37 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 6
Pirinen E, Soini Y. A survey of zeb1, twist and claudin 1 and 4 expression during placental development and disease. APMIS. 2014;122:530-8 pubmed 出版商
  • 免疫印迹; pigs ; 1:2000
Richter J, Pieper R, Zakrzewski S, Gunzel D, Schulzke J, Van Kessel A. Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon. Br J Nutr. 2014;111:1040-9 pubmed 出版商
  • 免疫细胞化学; 犬
  • 免疫印迹; 犬
Rincon Heredia R, Flores Benitez D, Flores Maldonado C, Bonilla Delgado J, García Hernández V, Verdejo Torres O, et al. Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways. Exp Cell Res. 2014;320:108-18 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 1
  • 免疫印迹; 小鼠; 1:500; 图 1
Sugimoto K, Ichikawa Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, et al. The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. PLoS ONE. 2013;8:e75106 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Hwang M, Lee J, Lee K, Lee K. Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer. ACS Nano. 2013;7:8167-74 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, et al. p38? mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res. 2014;306:131-41 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Zhu J, Gao P, Wang Z, Song Y, Li A, Xu Y, et al. Clinicopathological significance of claudin-4 in gastric carcinoma. World J Surg Oncol. 2013;11:150 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 2
  • 免疫组化; 人类; 1:100; 图 1
Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, et al. Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano. Cell Tissue Res. 2013;354:481-94 pubmed 出版商
  • 免疫印迹; 人类; 图 11
Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K. Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2012;110:166-77 pubmed
  • 免疫组化-石蜡切片; 人类; 10 ug/ml
Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen N, et al. Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut. 2014;63:711-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250
Díaz Coránguez M, Segovia J, López Ornelas A, Puerta Guardo H, Ludert J, Chávez B, et al. Transmigration of neural stem cells across the blood brain barrier induced by glioma cells. PLoS ONE. 2013;8:e60655 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Benediktsdóttir B, Gudjonsson T, Baldursson O, Másson M. N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro. Eur J Pharm Biopharm. 2014;86:55-63 pubmed 出版商
  • 免疫组化; 人类
Farley A, Morris L, Vroegindeweij E, Depreter M, Vaidya H, Stenhouse F, et al. Dynamics of thymus organogenesis and colonization in early human development. Development. 2013;140:2015-26 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 S8
  • 免疫组化; 人类; 1:2000; 图 S4
Krishnan M, Lapierre L, Knowles B, Goldenring J. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell. 2013;24:818-31 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Lappi Blanco E, Lehtonen S, Sormunen R, Merikallio H, Soini Y, Kaarteenaho R. Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol. 2013;44:895-907 pubmed 出版商
  • 免疫印迹; 人类; 图 s10
Whitcomb D, Larusch J, Krasinskas A, Klei L, Smith J, Brand R, et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012;44:1349-54 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, et al. Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. Cell Tissue Res. 2013;351:73-84 pubmed 出版商
  • 免疫印迹; 人类; 图 4
D Amato N, OSTRANDER J, Bowie M, Sistrunk C, Borowsky A, Cardiff R, et al. Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. PLoS ONE. 2012;7:e45684 pubmed 出版商
  • 免疫细胞化学; pigs ; 图 2a
  • 免疫印迹; pigs ; 1:250
Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, et al. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases. Toxicol Sci. 2012;130:180-90 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Moran G, O NEILL C, McLaughlin J. GLP-2 enhances barrier formation and attenuates TNF?-induced changes in a Caco-2 cell model of the intestinal barrier. Regul Pept. 2012;178:95-101 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 4
Lee K, Lee N, Kim J, Kang M, Yoo H, Kim H, et al. Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer. Biochem Biophys Res Commun. 2012;423:454-60 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Tabariès S, Dupuy F, Dong Z, Monast A, Annis M, Spicer J, et al. Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes. Mol Cell Biol. 2012;32:2979-91 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 2
Raiko L, Siljamäki E, Mahoney M, Putaala H, Suominen E, Peltonen J, et al. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol. 2012;21:586-91 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100
  • 免疫印迹; 人类; 1:1000; 图 2
Ghule V, Gray C, Galimberti A, Anumba D. Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins. J Transl Med. 2012;10:40 pubmed 出版商
  • 免疫细胞化学; 犬; 图 1
  • 免疫印迹; 犬; 图 2, 4
Dukes J, Whitley P, Chalmers A. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS ONE. 2012;7:e28659 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:75; 图 1
Pezzolato M, Maina E, Lonardi S, Bozzetta E, Grassi F, Scanziani E, et al. Development of tertiary lymphoid structures in the kidneys of pigs with chronic leptospiral nephritis. Vet Immunol Immunopathol. 2012;145:546-50 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2
Riski M, Santala M, Soini Y, Talvensaari Mattila A. Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma. Tumour Biol. 2012;33:537-42 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, et al. Protein kinase C? inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. Cell Tissue Res. 2011;346:369-81 pubmed 出版商
  • 免疫细胞化学; 犬; 图 s1a
Larre I, Castillo A, Flores Maldonado C, Contreras R, Galván I, Muñoz Estrada J, et al. Ouabain modulates ciliogenesis in epithelial cells. Proc Natl Acad Sci U S A. 2011;108:20591-6 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 1
Buckner L, Schust D, Ding J, Nagamatsu T, Beatty W, Chang T, et al. Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. J Reprod Immunol. 2011;92:8-20 pubmed 出版商
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Lorenzi L, Lonardi S, Petrilli G, Tanda F, Bella M, Laurino L, et al. Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. Hum Pathol. 2012;43:209-15 pubmed 出版商
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Horbul J, Schmechel S, Miller B, Rice S, Southern P. Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture. PLoS ONE. 2011;6:e22638 pubmed 出版商
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Dukes J, Fish L, Richardson J, Blaikley E, Burns S, Caunt C, et al. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Mol Biol Cell. 2011;22:3192-205 pubmed 出版商
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Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, et al. Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells. Cell Mol Biol Lett. 2011;16:385-97 pubmed 出版商
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  • 免疫细胞化学; 人类; 0.25 ug/ml; 图 7b
  • 免疫印迹; 人类; 图 7a
Boylan K, Misemer B, De Rycke M, Andersen J, Harrington K, Kalloger S, et al. Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation. Int J Mol Sci. 2011;12:1334-58 pubmed 出版商
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Rimpiläinen R, Vakkala M, Rimpiläinen E, Jensen H, Rimpiläinen J, Erkinaro T, et al. Minimized and conventional cardiopulmonary bypass damage intestinal mucosal integrity. Scand Cardiovasc J. 2011;45:236-46 pubmed 出版商
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Lonardi S, Manera C, Marucci R, Santoro A, Lorenzi L, Facchetti F. Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions. Diagn Cytopathol. 2011;39:313-7 pubmed 出版商
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Maria O, Zeitouni A, Gologan O, Tran S. Matrigel improves functional properties of primary human salivary gland cells. Tissue Eng Part A. 2011;17:1229-38 pubmed 出版商
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Pinton P, Braicu C, Nougayrede J, Laffitte J, Taranu I, Oswald I. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism. J Nutr. 2010;140:1956-62 pubmed 出版商
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Sung C, Han S, Kim S. Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma. Ann Surg Oncol. 2011;18:273-81 pubmed 出版商
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Väre P, Soini Y. Twist is inversely associated with claudins in germ cell tumors of the testis. APMIS. 2010;118:640-7 pubmed 出版商
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Perrone F, Jocollè G, Pennati M, Deraco M, Baratti D, Brich S, et al. Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma. Eur J Cancer. 2010;46:2837-48 pubmed 出版商
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  • 免疫组化; 人类; 图 2
  • 免疫印迹; 人类; 图 2
Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, et al. Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy. Am J Pathol. 2010;177:1344-55 pubmed 出版商
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Vockel M, Breitenbach U, Kreienkamp H, Brandner J. Somatostatin regulates tight junction function and composition in human keratinocytes. Exp Dermatol. 2010;19:888-94 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 3a
  • 免疫印迹; 人类; 1:1000; 图 2c
Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, et al. Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells. Am J Pathol. 2010;177:698-712 pubmed 出版商
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Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, et al. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J Cell Physiol. 2010;225:720-33 pubmed 出版商
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Kaarteenaho R, Merikallio H, Lehtonen S, Harju T, Soini Y. Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Respir Res. 2010;11:59 pubmed 出版商
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Hsueh C, Chang Y, Tseng N, Liao C, Hsueh S, Chang J, et al. Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma. Hum Pathol. 2010;41:944-50 pubmed 出版商
  • 免疫组化; 人类; 图 3a
  • 免疫印迹; 人类; 图 3b
Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, et al. Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis. 2010;16:1311-21 pubmed 出版商
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Kojima F, Ishida M, Takikita Suzuki M, Hotta M, Katsura K, Nagata A, et al. Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma. Oncol Rep. 2010;23:927-31 pubmed
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Poliani P, Kisand K, Marrella V, Ravanini M, Notarangelo L, Villa A, et al. Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells. Am J Pathol. 2010;176:1104-12 pubmed 出版商
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Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, et al. Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro. Med Mol Morphol. 2009;42:204-11 pubmed 出版商
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Zorko M, Veranic P, Leskovec N, Pavlovic M, Lunder T. Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers. Clin Exp Dermatol. 2009;34:e949-52 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 5 ug/ml
  • 免疫印迹; 大鼠; 2 ug/ml
Nicholson M, Lindsay L, Murphy C. Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy. Acta Histochem. 2010;112:42-52 pubmed 出版商
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Tanaka M, Fukushima N, Noda N, Shibahara J, Kokudo N, Fukayama M. Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases. Hum Pathol. 2009;40:1543-52 pubmed 出版商
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Natoli M, Felsani A, Ferruzza S, Sambuy Y, Canali R, Scarino M. Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells. Toxicol In Vitro. 2009;23:1510-5 pubmed 出版商
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  • 免疫细胞化学; pigs ; 图 3
  • 免疫印迹; pigs ; 图 3
  • 免疫细胞化学; 人类; 1:100; 图 3
  • 免疫印迹; 人类; 1:500; 图 3
Pinton P, Nougayrede J, del Rio J, Moreno C, Marin D, Ferrier L, et al. The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression. Toxicol Appl Pharmacol. 2009;237:41-8 pubmed 出版商
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Alanne M, Pummi K, Heape A, Grenman R, Peltonen J, Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J Histochem Cytochem. 2009;57:523-9 pubmed 出版商
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  • 免疫印迹; 人类; 1:1000; 图 1a
Lanigan F, McKiernan E, Brennan D, Hegarty S, Millikan R, McBryan J, et al. Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer. Int J Cancer. 2009;124:2088-97 pubmed 出版商
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Ishida M, Kushima R, Okabe H. Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors). Oncol Rep. 2009;21:113-7 pubmed
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Cao D, Polyak K, Halushka M, Nassar H, Kouprina N, Iacobuzio Donahue C, et al. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10:R91 pubmed 出版商
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Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, et al. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. J Pathol. 2008;216:356-64 pubmed 出版商
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  • 免疫印迹; 人类; 图 1
Aono S, Hirai Y. Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res. 2008;314:3326-39 pubmed 出版商
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Weber C, Nalle S, Tretiakova M, Rubin D, Turner J. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008;88:1110-20 pubmed 出版商
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Bouschbacher M, Bomsel M, Verronèse E, Gofflo S, Ganor Y, Dezutter Dambuyant C, et al. Early events in HIV transmission through a human reconstructed vaginal mucosa. AIDS. 2008;22:1257-66 pubmed 出版商
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Bello I, Vilen S, Niinimaa A, Kantola S, Soini Y, Salo T. Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue. Hum Pathol. 2008;39:1212-20 pubmed 出版商
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Tipsmark C, Luckenbach J, Madsen S, Kiilerich P, Borski R. Osmoregulation and expression of ion transport proteins and putative claudins in the gill of southern flounder (Paralichthys lethostigma). Comp Biochem Physiol A Mol Integr Physiol. 2008;150:265-73 pubmed 出版商
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Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F. Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation. Int J Surg Pathol. 2008;16:218-21 pubmed 出版商
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Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, et al. Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro. J Mol Histol. 2008;39:265-73 pubmed 出版商
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Tipsmark C, Baltzegar D, Ozden O, Grubb B, Borski R. Salinity regulates claudin mRNA and protein expression in the teleost gill. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1004-14 pubmed 出版商
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Ishikawa Y, Akishima Fukasawa Y, Ito K, Akasaka Y, Yokoo T, Ishii T. Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. Cancer. 2008;112:924-33 pubmed 出版商
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Väre P, Loikkanen I, Hirvikoski P, Vaarala M, Soini Y. Low claudin expression is associated with high Gleason grade in prostate adenocarcinoma. Oncol Rep. 2008;19:25-31 pubmed
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Reynolds G, Harris H, Jennings A, Hu K, Grove J, Lalor P, et al. Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology. 2008;47:418-27 pubmed
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Tzelepi V, Tsamandas A, Vlotinou H, Vagianos C, Scopa C. Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms. Mod Pathol. 2008;21:22-30 pubmed
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Atsumi T, Kato K, Uno K, Iijima K, Koike T, Imatani A, et al. Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer. Pathol Int. 2007;57:635-44 pubmed
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Choi Y, Kim J, Kwon M, Choi J, Kim T, Bae D, et al. Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. Histol Histopathol. 2007;22:1185-95 pubmed 出版商
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Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, et al. Decreased expression of claudin-1 correlates with recurrence status in breast cancer. Int J Mol Med. 2007;20:139-43 pubmed
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Paschoud S, Bongiovanni M, Pache J, Citi S. Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol. 2007;20:947-54 pubmed
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  • 免疫细胞化学; 人类; 2 ug/ml; 图 7
  • 免疫印迹; 人类; 0.5 ug/ml; 图 6B
Southgate J, Varley C, Garthwaite M, Hinley J, Marsh F, Stahlschmidt J, et al. Differentiation potential of urothelium from patients with benign bladder dysfunction. BJU Int. 2007;99:1506-16 pubmed
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Peltonen S, Riehokainen J, Pummi K, Peltonen J. Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis. Br J Dermatol. 2007;156:466-72 pubmed
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Soini Y, Talvensaari Mattila A. Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types. Int J Gynecol Pathol. 2006;25:330-5 pubmed
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Ichimiya S, Kojima T. Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors. J Histochem Cytochem. 2006;54:1277-89 pubmed
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  • 免疫印迹; 人类; 图 3a
Varley C, Garthwaite M, Cross W, Hinley J, Trejdosiewicz L, Southgate J. PPARgamma-regulated tight junction development during human urothelial cytodifferentiation. J Cell Physiol. 2006;208:407-17 pubmed
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Liévano S, Alarcón L, Chavez Munguia B, Gonzalez Mariscal L. Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia. Cell Tissue Res. 2006;324:433-48 pubmed
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Soini Y, Kinnula V, Kahlos K, Paakko P. Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura. J Clin Pathol. 2006;59:250-4 pubmed
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Lódi C, Szabó E, Holczbauer A, Batmunkh E, Szijarto A, Kupcsulik P, et al. Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. Mod Pathol. 2006;19:460-9 pubmed
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de Oliveira S, de Oliveira I, de Souza W, Morgado Diaz J. Claudins upregulation in human colorectal cancer. FEBS Lett. 2005;579:6179-85 pubmed
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Willemsen L, Hoetjes J, van Deventer S, van Tol E. Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol. 2005;142:275-84 pubmed
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Soini Y, Tommola S, Helin H, Martikainen P. Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype. Virchows Arch. 2006;448:52-8 pubmed
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Schierack P, Nordhoff M, Pollmann M, Weyrauch K, Amasheh S, Lodemann U, et al. Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Histochem Cell Biol. 2006;125:293-305 pubmed
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Resnick M, Gavilanez M, Newton E, Konkin T, Bhattacharya B, Britt D, et al. Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation. Hum Pathol. 2005;36:886-92 pubmed
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Shlyonsky V, Goolaerts A, Van Beneden R, Sariban Sohraby S. Differentiation of epithelial Na+ channel function. An in vitro model. J Biol Chem. 2005;280:24181-7 pubmed
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Soini Y. Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma. Hum Pathol. 2004;35:1531-6 pubmed
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Go M, Kojima T, Takano K, Murata M, Ichimiya S, Tsubota H, et al. Expression and function of tight junctions in the crypt epithelium of human palatine tonsils. J Histochem Cytochem. 2004;52:1627-38 pubmed
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Páska C, Bögi K, Szilak L, Tokés A, Szabó E, Sziller I, et al. Effect of formalin, acetone, and RNAlater fixatives on tissue preservation and different size amplicons by real-time PCR from paraffin-embedded tissue. Diagn Mol Pathol. 2004;13:234-40 pubmed
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Resnick M, Konkin T, Routhier J, Sabo E, Pricolo V. Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Mod Pathol. 2005;18:511-8 pubmed
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Zeng R, Li X, Gorodeski G. Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation. J Clin Endocrinol Metab. 2004;89:5145-55 pubmed
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Morita K, Tsukita S, Miyachi Y. Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease. Br J Dermatol. 2004;151:328-34 pubmed
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Nichols L, Ashfaq R, Iacobuzio Donahue C. Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target. Am J Clin Pathol. 2004;121:226-30 pubmed
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Sato N, Fukushima N, Maitra A, Iacobuzio Donahue C, Van Heek N, Cameron J, et al. Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas. Am J Pathol. 2004;164:903-14 pubmed
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Carson D, Lagow E, Thathiah A, Al Shami R, Farach Carson M, Vernon M, et al. Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening. Mol Hum Reprod. 2002;8:871-9 pubmed
Tratnjek L, Sibinovska N, Kralj S, Makovec D, Kristan K, Kreft M. Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing. Sci Rep. 2021;11:6664 pubmed 出版商
Munis A, Hyde S, Gill D. A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications. Mol Ther Methods Clin Dev. 2021;20:237-246 pubmed 出版商
El Chami C, Foster A, Johnson C, Clausen R, Cornwell P, Haslam I, et al. Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes. Br J Dermatol. 2021;184:482-494 pubmed 出版商
Orlando K, Douglas A, Abudu A, Wang Y, Tessier Cloutier B, Su W, et al. Re-expression of SMARCA4/BRG1 in small cell carcinoma of ovary, hypercalcemic type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism. elife. 2020;9: pubmed 出版商
Xu X, Zhang X, Gao L, Liu C, You K. Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development. Oxid Med Cell Longev. 2020;2020:2641461 pubmed 出版商
Ziegler A, Pridgen T, Blikslager A. Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model. Tissue Barriers. 2020;8:1832421 pubmed 出版商
Uc P, Miranda J, Raya Sandino A, Alarcón L, Roldán M, Ocadiz Delgado R, et al. E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions. Int J Oncol. 2020;57:905-924 pubmed 出版商
Carneiro F, Amorim R, de Vasconcelos Carneiro M, de Castro T, de Souza Vianna L, Takano G, et al. P16 as a marker of carcinoma in effusions and peritoneal washing. BMC Cancer. 2020;20:225 pubmed 出版商
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Sayoc Becerra A, Krishnan M, Fan S, Jimenez J, HERNANDEZ R, Gibson K, et al. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction. Inflamm Bowel Dis. 2020;26:407-422 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1)
目录# :
32-9400
规格 :
100微克
价格 :
美国419.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 大鼠
应用 :
Immunohistochemistry: 2-3 µg/mL, Western Blot: 0.5 - 3 µg/mL
物种 :
狗, 人类, 小鼠, 大鼠
克隆 :
3E2C1
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl - permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
免疫原 :
Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.
格式 :
液体
应用w/稀释 :
Immunohistochemistry: 2-3 µg/mL, Western Blot: 0.5 - 3 µg/mL
别名 :
Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国