产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1), Alexa Fluor系列荧光染料488
目录 :
329488
规格 :
100微克
价格 :
美国419
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF488
克隆名称 :
3E2C1
反应物种 :
人类, 小鼠, 大鼠, 犬
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 4
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 犬; 图 6
  • 免疫印迹; 犬; 图 3
Fredriksson K, Van Itallie C, Aponte A, Gucek M, Tietgens A, Anderson J. Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. PLoS ONE. 2015;10:e0117074 pubmed 出版商
  • 免疫组化; 人类; 图 4
Kirk A, Campbell S, Bass P, Mason J, Collins J. Differential expression of claudin tight junction proteins in the human cortical nephron. Nephrol Dial Transplant. 2010;25:2107-19 pubmed 出版商
Lashhab R, Rumley A, Arutyunov D, Rizvi M, You C, Dimke H, et al. The kidney anion exchanger 1 affects tight junction properties via claudin-4. Sci Rep. 2019;9:3099 pubmed 出版商
Schwed Lustgarten D, Thompson J, Yu G, Vachani A, Vaidya B, Rao C, et al. Use of circulating tumor cell technology (CELLSEARCH) for the diagnosis of malignant pleural effusions. Ann Am Thorac Soc. 2013;10:582-9 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1), Alexa Fluor系列荧光染料488
目录# :
329488
规格 :
100微克
价格 :
美国419
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 大鼠
应用 :
免疫组化(石蜡):3微克/毫升
物种 :
狗, 人类, 小鼠, 大鼠
克隆 :
3E2C1
抗体亚型 :
IgG1
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl - permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
免疫原 :
Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.
格式 :
液体
应用w/稀释 :
免疫组化(石蜡):3微克/毫升
别名 :
Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国