产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1), Alexa Fluor系列荧光染料594
目录 :
329494
规格 :
100微克
价格 :
美国398
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
Alexa Fluor系列荧光染料594
克隆名称 :
3E2C1
反应物种 :
人类, 小鼠, 大鼠, 犬
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 大鼠; 1:500; 图 3
Cong X, Zhang Y, Li J, Mei M, Ding C, Xiang R, et al. Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells. J Cell Sci. 2015;128:2271-86 pubmed 出版商
Kim C, Galloway J, Lee K, Searson P. Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers. Bioconjug Chem. 2014;25:1893-901 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
水闸蛋白4单克隆抗体(3E2C1), Alexa Fluor系列荧光染料594
目录# :
329494
规格 :
100微克
价格 :
美国398
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
狗, 人类, 小鼠, 大鼠
应用 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
狗, 人类, 小鼠, 大鼠
克隆 :
3E2C1
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl - permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
免疫原 :
Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
Cep-r; claudin 4; CLAUDIN4; claudin-4; CLDN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPER; CPE-R; CPE-receptor; Cpetr; CPETR1; h CPE-receptor; hCPE-R; WBSCR8; Williams-Beuren syndrome chromosomal region 8 protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国