产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CDK1单克隆抗体(A17)
目录 :
33-1800
规格 :
200微克
价格 :
美国456.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A17
反应物种 :
人类, 小鼠, 大鼠, 鸡, 非洲爪蛙
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 7
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 s2
Kim A, Joseph S, Khan A, Epstein C, Sobel R, Huang T. Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin. Free Radic Biol Med. 2010;48:1501-12 pubmed 出版商
Jeon S, Yoon Y, Kim H, Han J, Lee K, Seol J, et al. Ablation of CRBN induces loss of type I collagen and SCH in mouse skin by fibroblast senescence via the p38 MAPK pathway. Aging (Albany NY). 2021;13:6406-6419 pubmed 出版商
Chai Z, Wang L, Zheng Y, Liang N, Wang X, Zheng Y, et al. PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer. Cancer Cell Int. 2019;19:277 pubmed 出版商
Miedlich S, Taya M, Young M, Hammes S. Paxillin and embryonic PolyAdenylation Binding Protein (ePABP) engage to regulate androgen-dependent Xenopus laevis oocyte maturation - A model of kinase-dependent regulation of protein expression. Mol Cell Endocrinol. 2017;448:87-97 pubmed 出版商
Hauser P, Dozmorov M, Bane B, Slobodov G, Culkin D, Hurst R. Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis. J Urol. 2008;179:764-9 pubmed
Hansel D, Dhara S, Huang R, Ashfaq R, Deasel M, Shimada Y, et al. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Am J Surg Pathol. 2005;29:390-9 pubmed
Manes T, Zheng D, Tognin S, Woodard A, Marchisio P, Languino L. Alpha(v)beta3 integrin expression up-regulates cdc2, which modulates cell migration. J Cell Biol. 2003;161:817-26 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CDK1单克隆抗体(A17)
目录# :
33-1800
规格 :
200微克
价格 :
美国456.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
两栖动物, 鸡, 人类, 小鼠, 大鼠, 非洲爪蛙
应用 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Frozen): 5-10 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 5 µg, Western Blot: 0.5-2 µg/mL
物种 :
两栖动物, 鸡, 人类, 小鼠, 大鼠, 非洲爪蛙
克隆 :
A17
抗体亚型 :
IgG2a, kappa
储存 :
-20°C
描述 :
CDK1 (CDC2, P34CDC2) is a member of the Ser/Thr protein kinase family. CDK1 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of CDK1 is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of CDK1 also play important regulatory roles in cell cycle control. Destruction of cyclin B during metaphase results in inactivation of CDK1, allowing mitotic exit and cell division. CDK1 also contributes to the control of DNA replication and can be inhibited by several transcriptional targets of p53, such as p21WAF. The ability of CDK1 to exercise control over the cell cycle is dependent upon the phosphorylation of Tyr15 in cdc2. Research studies have shown that expression of CDK1 in the brain has been linked to both neurogenesis and apoptosis. In vertebrates, multiple cyclins like CDK1 have been identified, including a total of eight such regulatory proteins in mammals. Alternatively spliced transcript variants encoding different isoforms of CDK1 have been found.
免疫原 :
Recombinant protein consisiting of the carboxy-terminal two-thirds of the Xenopus p34cdc2
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Frozen): 5-10 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: 5 µg, Western Blot: 0.5-2 µg/mL
别名 :
5363; ABL1; cdc; CDC2; cdc-2; cdc2 kinase; CDC28A; Cdc2a; cdc2-a; cdc2Dm; cdc2x1.1; CDCDm; CDK1; Cdk-1; cdk1.S; CDK1/CDC2; CDK1-A; cdk1-b; Cdk1-PA; CDKN1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; cell division control; cell division control protein 2 homolog; Cell division control protein 2 homolog 1; cell division control protein 2-A; cell division cycle 2 homolog A; cell division cycle 2 like; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; cell division protein kinase 1; Cell division protein kinase 1-A; CG5363; CG5363-PA; cyclin dependent kinase; cyclin dependent kinase 1; cyclin-dependent kinase; Cyclin-dependent kinase 1; cyclin-dependent kinase 1 S homeolog; cyclin-dependent kinase 1-A; D2366; Dcdc2; dCdk1; DKFZp686L20222; Dm cdc2; Dmcdc2; DmCdk1; Dmel CG5363; Dmel_CG5363; DNA polymerase delta catalytic subunit; DNA polymerase III; DNA-directed DNA polymerase delta POL3; group 4; HPR6; KCIP-1; l(2)31Eh; LD38718p; maturation-promoting factor; MGC111195; MGC53829; MPF; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; p34 protein kinase 1; p34 ; p34cdc2; p34-cdc2 homologue; POL3; Protein 1054; protein 2; PSTAIR; TEX1; unnamed protein product; xcdc2; XELAEV_18036802mg; YDL102W
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国