产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
核纤层蛋白B2单克隆抗体(E-3)
目录 :
33-2100
规格 :
100微克
价格 :
美国428
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
E-3
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 其他
更多信息或购买 :
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 5a
Müller B, Serafin F, Laucke L, Rheinhard W, Wimmer T, Stieger K. Characterization of Double-Strand Break Repair Protein Ku80 Location Within the Murine Retina. Invest Ophthalmol Vis Sci. 2022;63:22 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3i
  • 免疫印迹; 人类; 1:500; 图 3h
Chen X, Yao H, Kashif M, Revêchon G, Eriksson M, Hu J, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. elife. 2021;10: pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:100; 图 1
  • 免疫印迹; 大鼠; 1:1000; 图 1
Vincent K, Cornea V, Jong Y, Laferriere A, Kumar N, Mickeviciute A, et al. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016;7:10604 pubmed 出版商
  • 其他; 人类; 图 st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:400
Jung H, Tatar A, Tu Y, Nobumori C, Yang S, Goulbourne C, et al. An absence of nuclear lamins in keratinocytes leads to ichthyosis, defective epidermal barrier function, and intrusion of nuclear membranes and endoplasmic reticulum into the nuclear chromatin. Mol Cell Biol. 2014;34:4534-44 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 免疫印迹; 小鼠
Lee J, Tu Y, Tatar A, Wu D, Nobumori C, Jung H, et al. Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014;25:1666-75 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 6
  • 免疫印迹; 小鼠; 1:400; 图 1
Jung H, Nobumori C, Goulbourne C, Tu Y, Lee J, Tatar A, et al. Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013;110:E1923-32 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Kim Y, Sharov A, McDole K, Cheng M, Hao H, Fan C, et al. Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011;334:1706-10 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 1
  • 免疫印迹; 大鼠; 1:100; 图 5
Wakabayashi T, Mori T, Hirahara Y, Koike T, Kubota Y, Takamori Y, et al. Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina. Histochem Cell Biol. 2011;136:427-36 pubmed 出版商
Kronenberg Tenga R, Tatli M, Eibauer M, Wu W, Shin J, Bonne G, et al. A lamin A/C variant causing striated muscle disease provides insights into filament organization. J Cell Sci. 2021;134: pubmed 出版商
Feurle P, Abentung A, Cera I, Wahl N, Ablinger C, Bucher M, et al. SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes. EMBO J. 2021;40:e103701 pubmed 出版商
Bertero A, Fields P, Smith A, Leonard A, Beussman K, Sniadecki N, et al. Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. J Cell Biol. 2019;218:2919-2944 pubmed 出版商
Takamori Y, Hirahara Y, Wakabayashi T, Mori T, Koike T, Kataoka Y, et al. Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex. IBRO Rep. 2018;5:99-109 pubmed 出版商
Müller B, Ellinwood N, Lorenz B, Stieger K. Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues. Front Neurosci. 2018;12:286 pubmed 出版商
Gigante C, Dibattista M, Dong F, Zheng X, Yue S, Young S, et al. Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation. Nat Commun. 2017;8:15098 pubmed 出版商
Montagne R, Baranzelli A, Muharram G, Catherine L, Lesaffre M, Vinchent A, et al. MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering. Oncotarget. 2017;8:11268-11283 pubmed 出版商
Jung H, Coffinier C, Choe Y, Beigneux A, Davies B, Yang S, et al. Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA. Proc Natl Acad Sci U S A. 2012;109:E423-31 pubmed 出版商
Hass M, Yankner B. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005;280:36895-904 pubmed
Jong Y, Kumar V, Kingston A, Romano C, O Malley K. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005;280:30469-80 pubmed
O Malley K, Jong Y, Gonchar Y, Burkhalter A, Romano C. Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons. J Biol Chem. 2003;278:28210-9 pubmed
Riefler G, Firestein B. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J Biol Chem. 2001;276:48262-8 pubmed
产品信息
产品类型 :
抗体
产品名称 :
核纤层蛋白B2单克隆抗体(E-3)
目录# :
33-2100
规格 :
100微克
价格 :
美国428
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
鸡, 人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 0.5 - 3 µg/mL
物种 :
鸡, 人类, 小鼠, 大鼠
克隆 :
E-3
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
免疫原 :
Extracts from chicken nuclei
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 0.5 - 3 µg/mL
别名 :
EPM9; fc15d06; im:7142331; LAMB2; lamin; lamin A/C; lamin B2; lamin B2 S homeolog; lamin B3; lamin-B2; Lamin-L(II); LMN2; LMNA; lmnb2; lmnb2.S; lmnb2-a; lmnb2-b; MGC2721; RGD1563803; unnamed protein product; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国