产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
泛素相关的修饰因子-1单克隆抗体(21C7)
目录 :
33-2400
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
21C7
反应物种 :
Zaisan mole vole, African green monkey, Northern mole vole, 人类, 小鼠, 大鼠, 鸡, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, EMSA, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 119
出版应用/物种/样本/稀释 | 参考文献 |
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| Citro S, Chiocca S. Assessing the Role of Paralog-Specific Sumoylation of HDAC1. Methods Mol Biol. 2017;1510:329-337 pubmed
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| Mori F, Watanabe Y, Miki Y, Tanji K, Odagiri S, Eto K, et al. Ubiquitin-negative, eosinophilic neuronal cytoplasmic inclusions associated with stress granules and autophagy: an immunohistochemical investigation of two cases. Neuropathology. 2014;34:140-7 pubmed
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| Delfino D, Spinicelli S, Pozzesi N, Pierangeli S, Velardi E, Bruscoli S, et al. Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes. Cell Death Differ. 2011;18:183-90 pubmed 出版商
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| Wang Z, Ou X, Tong J, Li S, Wei L, Ouyang Y, et al. The SUMO pathway functions in mouse oocyte maturation. Cell Cycle. 2010;9:2640-6 pubmed
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| Muller S, Dobner T. The adenovirus E1B-55K oncoprotein induces SUMO modification of p53. Cell Cycle. 2008;7:754-8 pubmed
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| Navascues J, Bengoechea R, Tapia O, Vaque J, Lafarga M, Berciano M. Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Chromosoma. 2007;116:441-51 pubmed
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| Kim S, Namekawa S, Niswander L, Ward J, Lee J, Bardwell V, et al. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007;3:e62 pubmed
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| Ferguson B, Dovey C, Lilley K, Wyllie A, Rich T. Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein. J Proteome Res. 2007;6:2027-32 pubmed
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| Zanardi A, Giorgetti L, Botrugno O, Minucci S, Milani P, Pelicci P, et al. Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells. Mol Cell Proteomics. 2007;6:939-47 pubmed
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| Stankovic Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guerardel C, et al. An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Mol Cell Biol. 2007;27:2661-75 pubmed
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| Mohan R, Rao A, Gagliardi J, Tini M. SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment. Mol Cell Biol. 2007;27:229-43 pubmed
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| Roscic A, Möller A, Calzado M, Renner F, Wimmer V, Gresko E, et al. Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell. 2006;24:77-89 pubmed
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| Nelson D, Bhaskaran V, Foster W, Lehman McKeeman L. p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile. Toxicol Sci. 2006;94:272-80 pubmed
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| Vertegaal A, Andersen J, Ogg S, Hay R, Mann M, Lamond A. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics. 2006;5:2298-310 pubmed
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| Dellaire G, Ching R, Dehghani H, Ren Y, Bazett Jones D. The number of PML nuclear bodies increases in early S phase by a fission mechanism. J Cell Sci. 2006;119:1026-33 pubmed
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| Klenk C, Humrich J, Quitterer U, Lohse M. SUMO-1 controls the protein stability and the biological function of phosducin. J Biol Chem. 2006;281:8357-64 pubmed
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| Fu L, Gao Y, Sztul E. Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein. Neurobiol Dis. 2005;20:656-65 pubmed
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| Sadanari H, Yamada R, Ohnishi K, Matsubara K, Tanaka J. SUMO-1 modification of the major immediate-early (IE) 1 and 2 proteins of human cytomegalovirus is regulated by different mechanisms and modulates the intracellular localization of the IE1, but not IE2, protein. Arch Virol. 2005;150:1763-82 pubmed
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| Rizos H, Woodruff S, Kefford R. p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners. Cell Cycle. 2005;4:597-603 pubmed
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| Wasylyk C, Criqui Filipe P, Wasylyk B. Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net. Oncogene. 2005;24:820-8 pubmed
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| Smolen G, Vassileva M, Wells J, Matunis M, Haber D. SUMO-1 modification of the Wilms' tumor suppressor WT1. Cancer Res. 2004;64:7846-51 pubmed
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| Yamashita D, Yamaguchi T, Shimizu M, Nakata N, Hirose F, Osumi T. The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain. Genes Cells. 2004;9:1017-29 pubmed
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| Spengler M, Kennett S, Moorefield K, Simmons S, Brattain M, Horowitz J. Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism. Cell Signal. 2005;17:153-66 pubmed
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| Woods Y, Xirodimas D, Prescott A, Sparks A, Lane D, Saville M. p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase. J Biol Chem. 2004;279:50157-66 pubmed
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| Nevels M, Brune W, Shenk T. SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication. J Virol. 2004;78:7803-12 pubmed
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| Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, et al. Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol. 2004;18:2451-62 pubmed
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| Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, et al. Modification of the erythroid transcription factor GATA-1 by SUMO-1. Proc Natl Acad Sci U S A. 2004;101:8870-5 pubmed
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| Pountney D, Huang Y, Burns R, Haan E, Thompson P, Blumbergs P, et al. SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease. Exp Neurol. 2003;184:436-46 pubmed
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| Xu L, Yang L, Moitra P, Hashimoto K, Rallabhandi P, Kaul S, et al. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Exp Cell Res. 2003;288:84-93 pubmed
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| Endter C, Kzhyshkowska J, Stauber R, Dobner T. SUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoprotein. Proc Natl Acad Sci U S A. 2001;98:11312-7 pubmed
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| Tse W, Tang J, Jin O, Korsgren C, John K, Kung A, et al. A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem. 2001;276:23974-85 pubmed
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| Kinoshita Y, Jarell A, Flaman J, Foltz G, Schuster J, Sopher B, et al. Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells. J Biol Chem. 2001;276:6656-65 pubmed
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| Rangasamy D, Woytek K, Khan S, Wilson V. SUMO-1 modification of bovine papillomavirus E1 protein is required for intranuclear accumulation. J Biol Chem. 2000;275:37999-8004 pubmed
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| Rangasamy D, Wilson V. Bovine papillomavirus E1 protein is sumoylated by the host cell Ubc9 protein. J Biol Chem. 2000;275:30487-95 pubmed
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| Saitoh H, Hinchey J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem. 2000;275:6252-8 pubmed
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| Hofmann H, Flöss S, Stamminger T. Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b. J Virol. 2000;74:2510-24 pubmed
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| Sternsdorf T, Puccetti E, Jensen K, Hoelzer D, Will H, Ottmann O, et al. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Mol Cell Biol. 1999;19:5170-8 pubmed
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| Desterro J, Rodriguez M, Hay R. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell. 1998;2:233-9 pubmed
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Patil H, Yoon D, Bhowmick R, Cai Y, Cho K, Ferreira P. Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I . Small Gtpases. 2019;10:146-161 pubmed 出版商
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Brown J, Conn K, Wasson P, Charman M, Tong L, Grant K, et al. SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. J Virol. 2016;90:5939-5952 pubmed 出版商
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Rytinki M, Kaikkonen S, Sutinen P, Paakinaho V, Rahkama V, Palvimo J. Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus. Mol Cell Biol. 2012;32:4195-205 pubmed
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Prost S, Lu P, Caldwell H, Harrison D. E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells. Oncogene. 2007;26:3572-81 pubmed
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Jones M, Fusi L, Higham J, Abdel Hafiz H, Horwitz K, Lam E, et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006;103:16272-7 pubmed
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Anckar J, Hietakangas V, Denessiouk K, Thiele D, Johnson M, Sistonen L. Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol Cell Biol. 2006;26:955-64 pubmed
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Hietakangas V, Anckar J, Blomster H, Fujimoto M, Palvimo J, Nakai A, et al. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci U S A. 2006;103:45-50 pubmed
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Kuo H, Chang C, Jeng J, Hu H, Lin D, Maul G, et al. SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Proc Natl Acad Sci U S A. 2005;102:16973-8 pubmed
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Shyu Y, Lee T, Ting C, Wen S, Hsieh L, Li Y, et al. Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus. Mol Cell Biol. 2005;25:10365-78 pubmed
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Long J, Zuo D, Park M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J Biol Chem. 2005;280:35477-89 pubmed
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Yamaguchi T, Sharma P, Athanasiou M, Kumar A, Yamada S, Kuehn M. Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol Cell Biol. 2005;25:5171-82 pubmed
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Tago K, Chiocca S, Sherr C. Sumoylation induced by the Arf tumor suppressor: a p53-independent function. Proc Natl Acad Sci U S A. 2005;102:7689-94 pubmed
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Ihara M, Yamamoto H, Kikuchi A. SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4. Mol Cell Biol. 2005;25:3506-18 pubmed
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Zoumi A, Datta S, Liaw L, Wu C, Manthripragada G, Osborne T, et al. Spatial distribution and function of sterol regulatory element-binding protein 1a and 2 homo- and heterodimers by in vivo two-photon imaging and spectroscopy fluorescence resonance energy transfer. Mol Cell Biol. 2005;25:2946-56 pubmed
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Lee M, Lebedeva L, Suzawa M, Wadekar S, Desclozeaux M, Ingraham H. The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol. 2005;25:1879-90 pubmed
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Boggio R, Colombo R, Hay R, Draetta G, Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004;16:549-61 pubmed
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Eskiw C, Dellaire G, Mymryk J, Bazett Jones D. Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly. J Cell Sci. 2003;116:4455-66 pubmed
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Saitoh H, Pizzi M, Wang J. Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358. J Biol Chem. 2002;277:4755-63 pubmed
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Matunis M, Coutavas E, Blobel G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol. 1996;135:1457-70 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
泛素相关的修饰因子-1单克隆抗体(21C7)
目录# :
33-2400
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
21C7
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment, via an isopeptide bond, to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 is involved, for instance, in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. SUMO1 may also regulate a network of genes involved in palate development. Mutations in the gene can result in non-syndromic orofacial cleft 10.
免疫原 :
全长重组GMP-1
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
CG4494-PA; DAP1; GAP modifying protein 1; GAP-modifying protein 1; GMP1; LD07775p; OFC10; OK/SW-cl.43; OTTHUMP00000202403; OTTHUMP00000202404; OTTHUMP00000202405; OTTHUMP00000202406; OTTHUMP00000202409; OTTHUMP00000202410; PIC1; SENP2; sentrin; Sentrin-1; small ubiquitin-like modifier 1; small ubiquitin-related modifier 1; small ubiquitin-related modifier-1; SMT3; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 1 (yeast); Smt3C; Smt3h3; SMTP3; Sumo1; SUMO-1; SUMO-1 related peptidase; Ubiquitin-homology domain protein PIC1; ubiquitin-like 1; ubiquitin-like 1 (sentrin); ubiquitin-like protein SMT3C; Ubiquitin-like protein UBL1; UBL1
更多信息或购买 :
公司信息
赛默飞世尔