产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化信号传导子及转录激活子1(Tyr701)单克隆抗体(ST1P-11A5)
目录 :
33-3400
规格 :
50微克
价格 :
美国454.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
ST1P-11A5
反应物种 :
African green monkey, 人类, 小鼠, 大鼠, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 22
| 出版应用/物种/样本/稀释 | 参考文献 |
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| de Lang A, Baas T, Teal T, Leijten L, Rain B, Osterhaus A, et al. Functional genomics highlights differential induction of antiviral pathways in the lungs of SARS-CoV-infected macaques. PLoS Pathog. 2007;3:e112 pubmed
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| Alblas J, Honing H, De Lavalette C, Brown M, Dijkstra C, van den Berg T. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Mol Cell Biol. 2005;25:7181-92 pubmed
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| Aksoy E, Zouain C, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, et al. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem. 2005;280:277-83 pubmed
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| Parkinson E, Townsend P, Stephanou A, Latchman D, Eaton S, Pierro A. The protective effect of moderate hypothermia during intestinal ischemia-reperfusion is associated with modification of hepatic transcription factor activation. J Pediatr Surg. 2004;39:696-701 pubmed
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| Duensing A, Medeiros F, McConarty B, Joseph N, Panigrahy D, Singer S, et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene. 2004;23:3999-4006 pubmed
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| Nepomuceno R, Balatoni C, Natkunam Y, Snow A, Krams S, Martinez O. Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas. Cancer Res. 2003;63:4472-80 pubmed
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| Nepomuceno R, Snow A, Robert Beatty P, Krams S, Martinez O. Constitutive activation of Jak/STAT proteins in Epstein-Barr virus-infected B-cell lines from patients with posttransplant lymphoproliferative disorder. Transplantation. 2002;74:396-402 pubmed
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Frost E, Ford E, Peters A, Reed N, McLaughlin E, Baker M, et al. Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line. Reprod Fertil Dev. 2020;32:1027-1039 pubmed 出版商
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Keller K, Yang Y, Sun Y, Walter M, Wirtz M. Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture. Mol Vis. 2019;25:266-282 pubmed
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Nelson E, Walker S, Li W, Liu X, Frank D. Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. J Biol Chem. 2006;281:26216-24 pubmed
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Zhang Y, Turkson J, Carter Su C, Smithgall T, Levitzki A, Kraker A, et al. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity. J Biol Chem. 2000;275:24935-44 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化信号传导子及转录激活子1(Tyr701)单克隆抗体(ST1P-11A5)
目录# :
33-3400
规格 :
50微克
价格 :
美国454.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
ChIP assay: 5 µg, ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-2 µg/mL
物种 :
人类, 小鼠
克隆 :
ST1P-11A5
抗体亚型 :
IgG2a, kappa
储存 :
-20°C
描述 :
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
免疫原 :
Synthetic phospho peptide encompassing the conserved C-terminal site (Y701) of murine STAT1 protein
格式 :
液体
应用w/稀释 :
ChIP assay: 5 µg, ELISA: 0.1-1.0 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 0.5-2 µg/mL
别名 :
2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84
更多信息或购买 :
公司信息
赛默飞世尔