产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
SR单克隆抗体(16H3(16H3E8))
目录 :
33-9300
规格 :
100微克
价格 :
美国428
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
16H3(16H3E8)
反应物种 :
人类, 小鼠, 大鼠, 犬, 鸡, 牛, domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 16
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:200; 图 3
Kaehler C, Guenther A, Uhlich A, Krobitsch S. PRMT1-mediated arginine methylation controls ATXN2L localization. Exp Cell Res. 2015;334:114-25 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa Y. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. Nucleic Acids Res. 2013;41:7060-72 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Vivarelli S, Lenzken S, Ruepp M, Ranzini F, Maffioletti A, Alvarez R, et al. Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2. PLoS ONE. 2013;8:e61980 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3
Walsh C, Suchanek A, Cyphert T, Kohan A, Szeszel Fedorowicz W, Salati L. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. J Biol Chem. 2013;288:2816-28 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 3
  • 免疫印迹; 人类; 1:100; 图 3
Toiber D, Azkona G, Ben Ari S, Toran N, Soreq H, Dierssen M. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis. 2010;40:348-59 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chandradas S, Deikus G, Tardos J, Bogdanov V. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. J Leukoc Biol. 2010;87:147-52 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Chen Y, Yuo C, Yang W, Jong Y, Lin H, Chang Y, et al. Extracellular pH change modulates the exon 7 splicing in SMN2 mRNA. Mol Cell Neurosci. 2008;39:268-72 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1
  • 免疫印迹; 小鼠; 图 2
Yomoda J, Muraki M, Kataoka N, Hosoya T, Suzuki M, Hagiwara M, et al. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells. 2008;13:233-44 pubmed 出版商
  • 免疫沉淀; 人类; 图 4
Exline C, Feng Z, Stoltzfus C. Negative and positive mRNA splicing elements act competitively to regulate human immunodeficiency virus type 1 vif gene expression. J Virol. 2008;82:3921-31 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Liang W, Yuo C, Chang J, Chen Y, Chang Y, Wang H, et al. The effect of hydroxyurea in spinal muscular atrophy cells and patients. J Neurol Sci. 2008;268:87-94 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Yuo C, Lin H, Chang Y, Yang W, Chang J. 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells. Ann Neurol. 2008;63:26-34 pubmed
  • 免疫印迹; 人类; 1:1000
Huang Y, Kim Y, Li Z, Fomenkov T, Fomenkov A, Ratovitski E. AEC-associated p63 mutations lead to alternative splicing/protein stabilization of p63 and modulation of Notch signaling. Cell Cycle. 2005;4:1440-7 pubmed
  • 免疫印迹; 小鼠
Chang J, Hsieh Li H, Jong Y, Wang N, Tsai C, Li H. Treatment of spinal muscular atrophy by sodium butyrate. Proc Natl Acad Sci U S A. 2001;98:9808-13 pubmed
Damodaran A, Courtheoux T, Watrin E, Prigent C. Alteration of SC35 localization by transfection reagents. Biochim Biophys Acta Mol Cell Res. 2020;1867:118650 pubmed 出版商
Martínez Pizarro A, Dembic M, Perez B, Andresen B, Desviat L. Intronic PAH gene mutations cause a splicing defect by a novel mechanism involving U1snRNP binding downstream of the 5' splice site. PLoS Genet. 2018;14:e1007360 pubmed 出版商
Tyson Capper A, Bailey J, Krainer A, Robson S, Europe Finner G. The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. J Biol Chem. 2005;280:34521-9 pubmed
产品信息
产品类型 :
抗体
产品名称 :
SR单克隆抗体(16H3(16H3E8))
目录# :
33-9300
规格 :
100微克
定价 :
美国428
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
牛, 狗, 鸡, 果蝇, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
应用 :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 0.5-2 µg/mL, Western Blot: 3-5 µg/mL
物种 :
牛, 狗, 鸡, 果蝇, 人类, 小鼠, 兔, 大鼠, 非洲爪蛙
克隆 :
16H3(16H3E8)
抗体亚型 :
IgG1, kappa
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
SR proteins are a highly conserved family of arginine/serine-rich, spliceosome-associated phosphoproteins essential for metazoan pre-mRNA splicing. SR proteins act early in splicing by promoting splice site recognition and spliceosome assembly. SR proteins also play a regulatory role because they can determine alternative splice site usage in vivo and in vitro. SR proteins appear to be recruited from nuclear “speckles”, in which they are concentrated to sites of transcription in order to spatially coordinate transcription and pre-mRNA splicing within the cell nucleus.
免疫原 :
Purified, de-phosphorylated bovine Srp55 and Drosophila p55-GST. The 16H3 epitope has been mapped to a 40-amino acid polypeptide composed almost exclusively of arginine alternating with glutamate and aspartate
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Immunocytochemistry: 0.5-2 µg/mL, Western Blot: 3-5 µg/mL
别名 :
1210001E11Rik; 5730499P16Rik; AI314910; AL024116; AW146126; AW550192; B52; Cl-4; Delayed-early protein HRS; epididymis secretory protein Li 91; HEL-S-91; HRS; hypothetical protein; insulin-induced growth response protein CL-4; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 4; MNCb-2616; pre-mRNA splicing factor SRp20; pre-mRNA-splicing factor SRP20; Pre-mRNA-splicing factor SRP40; pre-mRNA-splicing factor SRP55; Pre-mRNA-splicing factor SRP75; Protein X16; RGD1561347; serine and arginine rich splicing factor 3; serine and arginine rich splicing factor 4; serine and arginine rich splicing factor 5; serine and arginine rich splicing factor 6; serine/arginine-rich splicing factor 3; Serine/arginine-rich splicing factor 4; serine/arginine-rich splicing factor 5; Serine/arginine-rich splicing factor 6; SFRS3; Sfrs4; Sfrs5; Sfrs6; splicing factor; splicing factor arginine/serine-rich 5 (SRp40 HRS); splicing factor SRp55; splicing factor SRp55 homolog; splicing factor SRp55-1; splicing factor, arginine/serine-rich 3; splicing factor, arginine/serine-rich 3 (SRp20); splicing factor, arginine/serine-rich 4; splicing factor, arginine/serine-rich 4 (SRp75); splicing factor, arginine/serine-rich 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS); splicing factor, arginine/serine-rich 6; splicing factor, arginine/serine-rich, 20-kD; splicing factor, arginine/serine-rich, 55 kDa; SR splicing factor 4; SR splicing factor 5; SR splicing factor 6; SRP001LB; Srp20; SRP40; SRP55; SRP55-1; SRP75; SRSF3; SRSF4; SRSF5; Srsf6; X16
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国