产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EphA2多克隆抗体
目录 :
34-7400
规格 :
100微克
价格 :
美国482
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, proximity ligation assay, 免疫组化基因敲除验证
更多信息或购买 :
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 1a
Stammes M, Prevoo H, Ter Horst M, Groot S, Van De Velde C, Chan A, et al. Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery. Int J Mol Sci. 2017;18: pubmed 出版商
  • proximity ligation assay; 人类; 1:350; 图 3b
  • 免疫组化-石蜡切片; 人类; 1:200; 图 5a
  • 免疫印迹; 人类; 1:500; 图 1a
Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed 出版商
  • 免疫沉淀; 人类; 图 3f
  • 免疫印迹; 人类; 图 3d
Barquilla A, Lamberto I, Noberini R, Heynen Genel S, Brill L, Pasquale E. Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell. 2016;27:2757-70 pubmed 出版商
  • 免疫组化基因敲除验证; 小鼠; 图 4
Amato K, Wang S, Tan L, Hastings A, Song W, Lovly C, et al. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res. 2016;76:305-18 pubmed 出版商
Zhou L, Lu X, Zhang B, Shi Y, Li Z. EphA2 as a new target for breast cancer and its potential clinical application. Int J Clin Exp Pathol. 2021;14:484-492 pubmed
Vaught D, Merkel A, Lynch C, Edwards J, Tantawy M, Hilliard T, et al. EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease. JBMR Plus. 2021;5:e10465 pubmed 出版商
Song W, Kim L, Han W, Hou Y, Edwards D, Wang S, et al. Phosphorylation of PLCγ1 by EphA2 Receptor Tyrosine Kinase Promotes Tumor Growth in Lung Cancer. Mol Cancer Res. 2020;18:1735-1743 pubmed 出版商
Edwards D, Ngwa V, Wang S, Shiuan E, Brantley Sieders D, Kim L, et al. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ. Sci Signal. 2017;10: pubmed 出版商
Song W, Hwang Y, Youngblood V, Cook R, Balko J, Chen J, et al. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene. 2017;36:5620-5630 pubmed 出版商
van Dodewaard De Jong J, Santegoets S, van de Ven P, Versluis J, Verheul H, de Gruijl T, et al. Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells. Oncoimmunology. 2016;5:e1105431 pubmed
产品信息
产品类型 :
抗体
产品名称 :
EphA2多克隆抗体
目录# :
34-7400
规格 :
100微克
价格 :
美国482
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类
应用 :
Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
免疫原 :
Synthetic peptide derived from the C-terminal region of the human EphA2 receptor protein.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
别名 :
ARCC2; AW545284; CTPA; CTPP1; CTRCT6; Eck; EPH receptor A2; Epha2; ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; I79_019726; Myk2; Sek2; Sek-2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国