产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(2C1-1D12)
目录 :
35-1300Z
规格 :
100µg
价格 :
美国345
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2C1-1D12
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 7
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 图 6b
  • 免疫印迹; 人类; 1:1000; 图 6a
Torres Martínez A, Gallardo Vera J, Lara Holguin A, Montano L, Rendón Huerta E. Claudin-6 enhances cell invasiveness through claudin-1 in AGS human adenocarcinoma gastric cancer cells. Exp Cell Res. 2017;350:226-235 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Shih M, Pan K, Cherng J. Possible Mechanisms of Di(2-ethylhexyl) Phthalate-Induced MMP-2 and MMP-9 Expression in A7r5 Rat Vascular Smooth Muscle Cells. Int J Mol Sci. 2015;16:28800-11 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Al Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al Tweigeri T, et al. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS ONE. 2011;6:e27339 pubmed 出版商
  • 免疫组化; 人类; 图 3
Fang J, Zhou H, Zeng C, Yang J, Liu Y, Huang X, et al. MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology. 2011;54:1729-40 pubmed 出版商
  • 免疫印迹; 人类; 1:300; 图 2
Liu H, Chen A, Guo F, Yuan L. A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate cancer PC-3 cells. Cancer Lett. 2010;295:27-37 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Liu H, Chen A, Guo F, Yuan L. Influence of osteopontin short hairpin RNA on the proliferation and invasion of human renal cancer cells. J Huazhong Univ Sci Technolog Med Sci. 2010;30:61-8 pubmed 出版商
Anjanappa M, Cardoso A, Cheng L, Mohamad S, Gunawan A, Rice S, et al. Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells. Cancer Res. 2017;77:2759-2769 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(2C1-1D12)
目录# :
35-1300Z
规格 :
100µg
价格 :
美国345
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 0.1 µg/mL, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 1:10 - 1:100, Immunoprecipitation: Assay Dependent, Western Blot: 1:500
物种 :
人类
克隆 :
2C1-1D12
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
免疫原 :
激活的重组人类基质金属蛋白酶-2蛋白
格式 :
液体
应用w/稀释 :
ELISA: 0.1 µg/mL, Immunohistochemistry (Frozen): 5 µg/mL, Immunohistochemistry (Paraffin): 1:10 - 1:100, Immunoprecipitation: Assay Dependent, Western Blot: 1:500
别名 :
72 kDa gelatinase; 72 kDa type IV collagenase; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; BOS_17032; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; GelA; Gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; Mmp2; MMP-2; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国