产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
水闸蛋白5单克隆抗体(4C3C2)
目录 :
35-2500
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4C3C2
反应物种 :
tiger salamander, black-tailed prairie dog, 人类, 小鼠, 大鼠, , pigs , 家羊
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 181
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:200; 图 8e
Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel M, et al. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathol. 2020;140:183-208 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 3c
Pellegrini L, Bonfio C, Chadwick J, Begum F, Skehel M, Lancaster M. Human CNS barrier-forming organoids with cerebrospinal fluid production. Science. 2020;: pubmed 出版商
  • 免疫组化; 小鼠; 图 1d
Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J. Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation. Front Physiol. 2019;10:2 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1h
Wevers N, Kasi D, Gray T, Wilschut K, Smith B, van Vught R, et al. A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport. Fluids Barriers CNS. 2018;15:23 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2a
Rempe R, Hartz A, Soldner E, Sokola B, Alluri S, Abner E, et al. Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy. J Neurosci. 2018;38:4301-4315 pubmed 出版商
  • 免疫印迹; 小鼠; 1:800; 图 4g, 4i
Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi J, Gangarossa G, et al. Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity. Neuroscience. 2018;370:130-138 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 3b
Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 5b
Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 7d
Chehaibi K, le Maire L, Bradoni S, Escolà J, Blanco Vaca F, Slimane M. Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury. Transl Res. 2017;182:27-48 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 6c
Huang L, Cao W, Deng Y, Zhu G, Han Y, Zeng H. Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes. BMC Neurosci. 2016;17:64 pubmed
  • 免疫细胞化学; 大鼠; 1:100; 图 3c
Mendonça M, Soares E, de Jesus M, Ceragioli H, Batista Ã, Nyúl Tóth Ã, et al. PEGylation of Reduced Graphene Oxide Induces Toxicity in Cells of the Blood-Brain Barrier: An in Vitro and in Vivo Study. Mol Pharm. 2016;13:3913-3924 pubmed
  • 免疫细胞化学; 小鼠; 图 s1
Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. J Cereb Blood Flow Metab. 2017;37:2471-2484 pubmed 出版商
  • 免疫组化-石蜡切片; 犬; 1:200; 图 2d
  • 免疫印迹; 犬; 1:1000; 图 1h
Ahn C, Shin D, Lee D, Kang S, Seok J, Kang H, et al. Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep. 2016;14:3697-703 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 2e
Clark P, Al Ahmad A, Qian T, Zhang R, Wilson H, Weichert J, et al. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016;13:3341-9 pubmed 出版商
  • 免疫组化; 大鼠; 1:50; 图 1d
  • 免疫印迹; 大鼠; 1:500; 图 3b
Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, et al. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res. 2016;1650:31-40 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 表 2
Peckova K, Michal M, Hadravsky L, Suster S, Damjanov I, Miesbauerova M, et al. Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies. Histopathology. 2016;69:762-774 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1
Nishida Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, et al. Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J Biol Chem. 2016;291:10490-500 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 5
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Sreekanthreddy P, Gromnicova R, Davies H, Phillips J, Romero I, Male D. A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions. F1000Res. 2015;4:1279 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3c
  • 免疫印迹; 人类; 图 3a
Schossleitner K, Rauscher S, Gröger M, Friedl H, Finsterwalder R, Habertheuer A, et al. Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo. Arterioscler Thromb Vasc Biol. 2016;36:647-54 pubmed 出版商
  • 免疫组化; tiger salamander; 1:500; 图 1
Rodrigo Albors A, Tazaki A, Rost F, Nowoshilow S, Chara O, Tanaka E. Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration. elife. 2015;4:e10230 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 2
Stebbins M, Wilson H, Canfield S, Qian T, Palecek S, Shusta E. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells. Methods. 2016;101:93-102 pubmed 出版商
  • 免疫组化; 小鼠; 1:50
Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, et al. Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. J Neurosci. 2015;35:12766-78 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50
  • 免疫印迹; 人类; 1:250
Zhao Y, Zhao L, Wang P, Miao Y, Liu Y, Wang Z, et al. Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin. J Neurosci Res. 2015;93:1891-902 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:50; 图 1
Zehendner C, Sebastiani A, Hugonnet A, Bischoff F, Luhmann H, Thal S. Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex. Sci Rep. 2015;5:13497 pubmed 出版商
  • 免疫印迹; 人类; 0.5 ug/ml
Smith N, Hinley J, Varley C, Eardley I, Trejdosiewicz L, Southgate J. The human urothelial tight junction: claudin 3 and the ZO-1α+ switch. Bladder (San Franc). 2015;2:e9 pubmed
  • 免疫印迹; 大鼠; 1:500
Tan F, Fu W, Cheng N, Meng D, Gu Y. Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion. Exp Ther Med. 2015;9:1757-1762 pubmed
  • 免疫组化-冰冻切片; 小鼠; 1:500
Shah K, Boreddy P, Abbruscato T. Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice. Fluids Barriers CNS. 2015;12:10 pubmed 出版商
  • 免疫印迹; 人类
Clark P, Kim R, Pober J, Kluger M. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10:e0120075 pubmed 出版商
  • 免疫印迹; 人类; 1:300-500
Sajja R, Green K, Cucullo L. Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. PLoS ONE. 2015;10:e0122358 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, et al. Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J Biol Chem. 2015;290:11515-25 pubmed 出版商
  • 免疫组化; 大鼠; 2 ug/ml
Ghersi Egea J, Babikian A, Blondel S, Strazielle N. Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation. Fluids Barriers CNS. 2015;12:8 pubmed 出版商
  • 免疫组化; black-tailed prairie dog; 1:100
Meekins J, Eshar D, Rankin A, Henningson J. Clinical and histologic description of ocular anatomy in captive black-tailed prairie dogs (Cynomys ludovicianus). Vet Ophthalmol. 2016;19:110-6 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50
Nissi R, Talvensaari Mattila A, Kuvaja P, Pääkkö P, Soini Y, Santala M. Claudin-5 is associated with elevated TATI and CA125 levels in mucinous ovarian borderline tumors. Anticancer Res. 2015;35:973-6 pubmed
  • 免疫组化; 人类; 1:150
Pienaar I, Lee C, Elson J, McGuinness L, Gentleman S, Kalaria R, et al. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiol Dis. 2015;74:392-405 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4a
Scotti L, Abramovich D, Pascuali N, Durand L, Irusta G, de Zúñiga I, et al. Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS). Reprod Fertil Dev. 2016;28:690-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
  • 免疫印迹; 人类; 1:125
Swager S, Delfín D, Rastogi N, Wang H, Canan B, Fedorov V, et al. Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1. Cardiovasc Pathol. 2015;24:160-167 pubmed 出版商
  • 免疫组化; 小鼠; 1:300; 图 4
  • 免疫印迹; 小鼠; 1:1000
Braniste V, Al Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6:263ra158 pubmed 出版商
  • 免疫印迹; 人类
Casselbrant A, Elias E, Fändriks L, Wallenius V. Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2015;11:45-53 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 6
Scotti L, Abramovich D, Pascuali N, Irusta G, Meresman G, Tesone M, et al. Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome. J Steroid Biochem Mol Biol. 2014;144 Pt B:392-401 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1e
Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, et al. Claudins as prognostic factors for renal cell cancer. Anticancer Res. 2014;34:4181-7 pubmed
  • 免疫印迹; 大鼠; 1:300
Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed 出版商
  • 免疫细胞化学; 人类
Takeshita Y, Obermeier B, Cotleur A, Sano Y, Kanda T, Ransohoff R. An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture. J Neurosci Methods. 2014;232:165-72 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:400
Ben Zvi A, Lacoste B, Kur E, Andreone B, Mayshar Y, Yan H, et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014;509:507-11 pubmed 出版商
  • 免疫细胞化学; 人类; 1:150
  • 免疫印迹; 人类; 1:350
Sajja R, Prasad S, Cucullo L. Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS. 2014;11:8 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50
Zehendner C, White R, Hedrich J, Luhmann H. A neurovascular blood-brain barrier in vitro model. Methods Mol Biol. 2014;1135:403-13 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50; 表 1
Zehendner C, Librizzi L, Hedrich J, Bauer N, Angamo E, de Curtis M, et al. Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption. PLoS ONE. 2013;8:e82823 pubmed 出版商
  • 免疫组化; 小鼠; 1:50; 图 1
Zehendner C, Wedler H, Luhmann H. A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex. PLoS ONE. 2013;8:e81637 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Hawkins K, Demars K, Singh J, Yang C, Cho H, Frankowski J, et al. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke. J Neurochem. 2014;129:130-42 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠; 1:500
Watson P, Paterson J, Thom G, Ginman U, Lundquist S, Webster C. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci. 2013;14:59 pubmed 出版商
  • 免疫印迹; 家羊; 1:5000; 图 2
Szczepkowska A, Lagaraine C, Robert V, Dufourny L, Thiery J, Skipor J. Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods. Neurotoxicol Teratol. 2013;37:63-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1b
Nordfors K, Haapasalo J, Sallinen P, Haapasalo H, Soini Y. Expression of claudins relates to tumour aggressivity, location and recurrence in ependymomas. Histol Histopathol. 2013;28:1137-46 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 4
Strazielle N, Ghersi Egea J. Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules. Mol Pharm. 2013;10:1473-91 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Lappi Blanco E, Lehtonen S, Sormunen R, Merikallio H, Soini Y, Kaarteenaho R. Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis. Hum Pathol. 2013;44:895-907 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类; 1:1000
Krouwer V, Hekking L, Langelaar Makkinje M, Regan Klapisz E, Post J. Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability. Vasc Cell. 2012;4:12 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1.25 ug/ml
  • 免疫印迹; 大鼠; 1 ug/ml; 图 2, 3
  • 免疫组化-石蜡切片; 人类; 2.5 ug/ml; 图 2, 3
Kratzer I, Vasiljevic A, Rey C, Fevre Montange M, Saunders N, Strazielle N, et al. Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier. Histochem Cell Biol. 2012;138:861-79 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 2
Northrop N, Yamamoto B. Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol. 2012;7:951-68 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4
Johnson H, Chen Y, Jin F, Hanson L, Gamez J, Pirko I, et al. CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support. J Immunol. 2012;189:1937-45 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:50; 图 2
  • 免疫印迹; 大鼠; 1:250; 图 2
Raposo C, Odorissi P, Oliveira A, Aoyama H, Ferreira C, Verinaud L, et al. Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier. Neurochem Res. 2012;37:1967-81 pubmed 出版商
  • 免疫印迹; 小鼠; 1:100; 图 2
Delfin D, Xu Y, Schill K, Mays T, Canan B, Zang K, et al. Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model. Mol Ther. 2012;20:1378-83 pubmed 出版商
  • 免疫组化; 大鼠; 图 6
Géraud C, Evdokimov K, Straub B, Peitsch W, Demory A, Dörflinger Y, et al. Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS ONE. 2012;7:e34206 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:100
  • 免疫印迹; 人类; 1:1000
Ghule V, Gray C, Galimberti A, Anumba D. Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins. J Transl Med. 2012;10:40 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 3
Riski M, Santala M, Soini Y, Talvensaari Mattila A. Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma. Tumour Biol. 2012;33:537-42 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
Lecuyer H, Nassif X, Coureuil M. Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells. Infect Immun. 2012;80:175-86 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 表 1
Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren Wiemers N, et al. Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis. Acta Neuropathol. 2011;122:601-14 pubmed 出版商
  • 免疫组化; 人类; 图 1
Miettinen M, Sarlomo Rikala M, Wang Z. Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas. Am J Surg Pathol. 2011;35:1848-56 pubmed 出版商
  • 免疫细胞化学; 人类; 1:150; 图 1
  • 免疫印迹; 人类; 1:500; 图 2
Mandel I, Paperna T, Glass Marmor L, Volkowich A, Badarny S, Schwartz I, et al. Tight junction proteins expression and modulation in immune cells and multiple sclerosis. J Cell Mol Med. 2012;16:765-75 pubmed 出版商
  • 免疫印迹; 家羊; 1:5000; 图 1
Lagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery J. Tight junction proteins vary in the choroid plexus of ewes according to photoperiod. Brain Res. 2011;1393:44-51 pubmed 出版商
  • 免疫组化; pigs ; 1:200; 图 1
Zehendner C, Librizzi L, de Curtis M, Kuhlmann C, Luhmann H. Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage. PLoS ONE. 2011;6:e16760 pubmed 出版商
  • 免疫印迹; pigs ; 图 1
Butt O, Buehler P, D Agnillo F. Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin. Am J Pathol. 2011;178:1316-28 pubmed 出版商
  • 免疫组化; 小鼠; 10 ug/ml; 图 2
  • 免疫印迹; 小鼠; 0.5 ug/ml; 图 3
Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, et al. Novel expression of claudin-5 in glomerular podocytes. Cell Tissue Res. 2011;343:637-48 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:45; 图 2
Manias J, Kapadia A, Nag S. Detection of multiple proteins in intracerebral vessels by confocal microscopy. Methods Mol Biol. 2011;686:177-92 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Su S, Maxwell S, Bayless K. Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. J Biol Chem. 2010;285:40624-34 pubmed 出版商
  • 免疫组化; 人类; 图 4
Powner M, Gillies M, Tretiach M, Scott A, Guymer R, Hageman G, et al. Perifoveal müller cell depletion in a case of macular telangiectasia type 2. Ophthalmology. 2010;117:2407-16 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 表 1
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HERRERA J, Haywood Watson R, Grill R. Acute and chronic deficits in the urinary bladder after spinal contusion injury in the adult rat. J Neurotrauma. 2010;27:423-31 pubmed 出版商
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Tang J, Kang Y, Huang L, Wu L, Peng Y. TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling. Acta Pharm Sin B. 2020;10:987-1003 pubmed 出版商
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Katt M, Mayo L, Ellis S, Mahairaki V, Rothstein J, Cheng L, et al. The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids Barriers CNS. 2019;16:20 pubmed 出版商
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Shigemoto Mogami Y, Hoshikawa K, Sato K. Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model. Front Cell Neurosci. 2018;12:494 pubmed 出版商
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Van Skike C, Jahrling J, Olson A, Sayre N, Hussong S, Ungvari Z, et al. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018;314:H693-H703 pubmed 出版商
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Mazzoni J, Smith J, Shahriar S, Cutforth T, Ceja B, Agalliu D. The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels. Neuron. 2017;96:1055-1069.e6 pubmed 出版商
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Huang L, Stuart C, Takeda K, D Agnillo F, Golding B. Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE. 2016;11:e0160875 pubmed 出版商
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Maria O, Kim J, Gerstenhaber J, Baum B, Tran S. Distribution of tight junction proteins in adult human salivary glands. J Histochem Cytochem. 2008;56:1093-8 pubmed 出版商
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Musch M, Walsh Reitz M, Chang E. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol. 2006;290:G222-31 pubmed
Weng X, Beyenbach K, Quaroni A. Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium. Am J Physiol Gastrointest Liver Physiol. 2005;288:G705-17 pubmed
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Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo L. The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. J Cell Sci. 2004;117:3307-18 pubmed
Poliak S, Matlis S, Ullmer C, Scherer S, Peles E. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. J Cell Biol. 2002;159:361-72 pubmed
产品信息
产品类型 :
抗体
产品名称 :
水闸蛋白5单克隆抗体(4C3C2)
目录# :
35-2500
规格 :
100微克
价格 :
美国399.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:1,000
物种 :
人类, 小鼠, 大鼠
克隆 :
4C3C2
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
免疫原 :
Synthetic peptide derived from the mouse Claudin-5 protein
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:1,000
别名 :
AI854493; AWAL; BEC1; Brain endothelial cell clone 1 protein; claudin 5; claudin 5 (transmembrane protein deleted in velocardiofacial syndrome); claudin-5; claudin-5 protein; Cldn5; CPETRL1; lung-specific membrane protein; MBEC1; TMDVCF; TMVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome; Unknown (protein for MGC:138054)
更多信息或购买 :
公司信息
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公司总部: 美国