产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ALK单克隆抗体(4C5B8)
目录 :
35-4300
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4C5B8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 8
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4
Ardini E, Menichincheri M, Banfi P, Bosotti R, De Ponti C, Pulci R, et al. Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications. Mol Cancer Ther. 2016;15:628-39 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1
  • 免疫组化; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Ceccon M, Merlo M, Mologni L, Poggio T, Varesio L, Menotti M, et al. Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene. 2016;35:3854-3865 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Cheng M, Quail M, Gingrich D, Ott G, Lu L, Wan W, et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2012;11:670-9 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Piva R, Chiarle R, Manazza A, Taulli R, Simmons W, Ambrogio C, et al. Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood. 2006;107:689-97 pubmed
Menotti M, Ambrogio C, Cheong T, Pighi C, Mota I, Cassel S, et al. Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma. Nat Med. 2019;25:130-140 pubmed 出版商
Shi B, Vishwamitra D, Granda J, Whitton T, Shi P, Amin H. Molecular and functional characterizations of the association and interactions between nucleophosmin-anaplastic lymphoma kinase and type I insulin-like growth factor receptor. Neoplasia. 2013;15:669-83 pubmed
Cui Y, Kerby A, McDuff F, Ye H, Turner S. NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner. Blood. 2009;113:5217-27 pubmed 出版商
Wan W, Albom M, Lu L, Quail M, Becknell N, Weinberg L, et al. Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells. Blood. 2006;107:1617-23 pubmed
产品信息
产品类型 :
抗体
产品名称 :
ALK单克隆抗体(4C5B8)
目录# :
35-4300
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
物种 :
人类
克隆 :
4C5B8
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
免疫原 :
Recombinant protein derived from the human ALK protein.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
别名 :
Alk; ALK tyrosine kinase receptor; anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国