产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
连接蛋白单克隆抗体(3D8A5)
目录 :
35-5000
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
3D8A5
反应物种 :
人类, 小鼠, 大鼠, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 28
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:100; 图 1b
Theofilas P, Steinhäuser C, Theis M, Derouiche A. Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells. J Neurosci Res. 2017;95:2182-2194 pubmed 出版商
  • 免疫印迹; domestic rabbit; 表 2
Chen X, Lu S, Huang K, Zhang W, Liu Z, Zhong J. Effects of Ang â…¡ perfusion on transmural heterogeneous of Cx43 in acute myocardial ischemia reperfusion. Asian Pac J Trop Med. 2016;9:96-9 pubmed 出版商
  • 免疫印迹; 小鼠
Kundu S, Pushpakumar S, Sen U. MMP-9- and NMDA receptor-mediated mechanism of diabetic renovascular remodeling and kidney dysfunction: hydrogen sulfide is a key modulator. Nitric Oxide. 2015;46:172-85 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫细胞化学; 小鼠
Bautista W, Rash J, Vanderpool K, Yasumura T, Nagy J. Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus. Eur J Neurosci. 2014;39:757-70 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:200; 图 2
  • 免疫组化-冰冻切片; 人类; 1:200; 图 3
  • 免疫组化-冰冻切片; 小鼠; 1:200; 图 1
Liang B, Nissen J, Laursen M, Wang X, Skibsbye L, Hearing M, et al. G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization. Cardiovasc Res. 2014;101:175-84 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 2 ug/ml
Lynn B, Tress O, May D, Willecke K, Nagy J. Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges. Eur J Neurosci. 2011;34:1783-93 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3
Takahashi D, Vargas J, Wilcox K. Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus. Neurobiol Dis. 2010;40:573-85 pubmed 出版商
  • 免疫组化; 大鼠
Procida K, Jørgensen L, Schmitt N, Delmar M, Taffet S, Holstein Rathlou N, et al. Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm. 2009;6:1632-8 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 3
ElZarrad M, Haroon A, Willecke K, Dobrowolski R, Gillespie M, Al Mehdi A. Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium. BMC Med. 2008;6:20 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:500; 图 2
Sorensen C, Salomonsson M, Braunstein T, Nielsen M, Holstein Rathlou N. Connexin mimetic peptides fail to inhibit vascular conducted calcium responses in renal arterioles. Am J Physiol Regul Integr Comp Physiol. 2008;295:R840-7 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Leaf D, Feig J, Vasquez C, Riva P, Yu C, Lader J, et al. Connexin40 imparts conduction heterogeneity to atrial tissue. Circ Res. 2008;103:1001-8 pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 2
Kang J, Kang N, Lovatt D, Torres A, Zhao Z, Lin J, et al. Connexin 43 hemichannels are permeable to ATP. J Neurosci. 2008;28:4702-11 pubmed 出版商
  • 免疫组化; 大鼠; 2 ug/ml; 图 3
Rash J, Olson C, Davidson K, Yasumura T, Kamasawa N, Nagy J. Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus. Neuroscience. 2007;147:938-56 pubmed
  • 免疫印迹; domestic rabbit; 1:1000; 图 3
Tansey E, Kwaku K, Hammer P, Cowan D, Federman M, Levitsky S, et al. Reduction and redistribution of gap and adherens junction proteins after ischemia and reperfusion. Ann Thorac Surg. 2006;82:1472-9 pubmed
  • 免疫组化-冰冻切片; 人类; 图 5
Van Der Aa F, Roskams T, Blyweert W, Ost D, Bogaert G, De Ridder D. Identification of kit positive cells in the human urinary tract. J Urol. 2004;171:2492-6 pubmed
  • 免疫组化-冰冻切片; 小鼠
Nagy J, Ionescu A, Lynn B, Rash J. Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice. Glia. 2003;44:205-18 pubmed
Veeranki S, Tyagi S. Mdivi-1 induced acute changes in the angiogenic profile after ischemia-reperfusion injury in female mice. Physiol Rep. 2017;5: pubmed 出版商
Tsao D, Wang S, Lynn B, Nagy J. Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin-D28K-positive interstitial cells in the pineal gland. Eur J Neurosci. 2017;45:1553-1569 pubmed 出版商
Schimenti K, Feuer S, Griffin L, Graham N, Bovet C, Hartford S, et al. AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics. 2013;194:447-57 pubmed 出版商
Kanady J, Dellinger M, Munger S, Witte M, Simon A. Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax. Dev Biol. 2011;354:253-66 pubmed 出版商
Li X, Penes M, Odermatt B, Willecke K, Nagy J. Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions. Eur J Neurosci. 2008;28:1503-17 pubmed 出版商
Rash J, Davidson K, Kamasawa N, Yasumura T, Kamasawa M, Zhang C, et al. Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb. J Neurocytol. 2005;34:307-41 pubmed
Cluff A, Bystrom B, Klimaviciute A, Dahlqvist C, Cebers G, Malmstrom A, et al. Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue. Reprod Biol Endocrinol. 2006;4:24 pubmed
Dobrenis K, Chang H, Pina Benabou M, Woodroffe A, Lee S, Rozental R, et al. Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons. J Neurosci Res. 2005;82:306-15 pubmed
Kamasawa N, Sik A, Morita M, Yasumura T, Davidson K, Nagy J, et al. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Neuroscience. 2005;136:65-86 pubmed
Penes M, Li X, Nagy J. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Eur J Neurosci. 2005;22:404-18 pubmed
Li X, Ionescu A, Lynn B, Lu S, Kamasawa N, Morita M, et al. Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain. Neuroscience. 2004;126:611-30 pubmed
Nagy J, Ionescu A, Lynn B, Rash J. Connexin29 and connexin32 at oligodendrocyte and astrocyte gap junctions and in myelin of the mouse central nervous system. J Comp Neurol. 2003;464:356-70 pubmed
产品信息
产品类型 :
抗体
产品名称 :
连接蛋白单克隆抗体(3D8A5)
目录# :
35-5000
规格 :
100微克
价格 :
美国375.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
小鼠, 大鼠
应用 :
Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
物种 :
小鼠, 大鼠
克隆 :
3D8A5
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of Cx43 is important in regulating assembly and function of gap junctions. Ser368 of Cx43 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate Cx43 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is also targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5. Mutations in the GFAP gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy, oculodentodigital dysplasia and heart malformations. Alternatively spliced transcript variants of GFAP have been found.
免疫原 :
Synthetic peptide derived from rat Connexin 43.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
别名 :
alpha 1 connexin; AU042049; AVSD3; AW546267; CMDR; Cnx43; connexin 43; connexin43; connexin-43; cx43; Cx-43; cx43 protein; cx43a1; Cx43alpha1; CXA1; Cxn-43; DFNB38; EKVP; etID309742.9; gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein; gap junction membrane channel protein alpha 1; gap junction protein; gap junction protein alpha 1; gap junction protein connexin 43; gap junction protein, alpha 1; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; gap junction protein, alpha 1, 43kDa (connexin 43); gja1; Gja-1; GJAL; HLHS1; HSS; Npm1; ODD; ODDD; ODOD; PPKCA; SDTY3; shf; Short fin protein; sof; stopsel; stp; Syndactyly type III; vascular smooth muscle connexin43; Vascular smooth muscle connexin-43; zfCx43.3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国