产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser396) Monoclonal Antibody (PHF13.6)
目录 :
35-5300
规格 :
50µg
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
克隆名称 :
PHF13.6
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 9
出版应用/物种/样品/稀释参考文献
  • 免疫组化-石蜡切片; 狗; 1:1000
  • 免疫印迹; 大鼠
  • 免疫印迹; 小鼠
Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Loeffler D, Smith L, Klaver A, Martić S. Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report. Exp Gerontol. 2015;67:15-8 pubmed 出版商
  • 免疫印迹; 人类; 图 3, 4
Sepúlveda Díaz J, Alavi Naini S, Huynh M, Ouidja M, Yanicostas C, Chantepie S, et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain. 2015;138:1339-54 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1
Li R, Xu D, Ma T. Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience. 2015;294:14-20 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3
Å polcová A, Mikulášková B, KrÅ¡ková K, GajdoÅ¡echová L, Zórad Å, Olszanecki R, et al. Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats. BMC Neurosci. 2014;15:111 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Spatara M, Robinson A. Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction. J Neurosci Res. 2010;88:1951-61 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200
Forno L, Langston J, Herrick M, Wilson J, Murayama S. Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type. Acta Neuropathol. 2002;103:599-606 pubmed
Yu F, Shukla D, Armstrong R, Marion C, Radomski K, Selwyn R, et al. Repetitive Model of Mild Traumatic Brain Injury Produces Cortical Abnormalities Detectable by Magnetic Resonance Diffusion Imaging, Histopathology, and Behavior. J Neurotrauma. 2017;34:1364-1381 pubmed 出版商
Hoffmann R, Lee V, Leight S, Varga I, Otvos L. Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry. 1997;36:8114-24 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser396) Monoclonal Antibody (PHF13.6)
目录# :
35-5300
规格 :
50µg
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: 3-5 µg/mL, Western Blot: 1-3 µg/mL
物种 :
人类
克隆 :
PHF13.6
抗体亚型 :
IgG2b
储存 :
-20°C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Purified human PHF-Tau preparation
格式 :
Liquid
应用w/稀释 :
ELISA: 3-5 µg/mL, Western Blot: 1-3 µg/mL
别名 :
MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国