产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NY-ESO单克隆抗体(E978)
目录 :
35-6200
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
E978
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 38
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:200; 图 s7
Srivastava P, Paluch B, Matsuzaki J, James S, Collamat Lai G, Blagitko Dorfs N, et al. Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy. Oncotarget. 2016;7:12840-56 pubmed 出版商
  • 流式细胞仪; 人类; 图 s1
  • 免疫印迹; 人类; 1:1000; 图 2b
Klar A, Gopinadh J, Kleber S, Wadle A, Renner C. Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing. PLoS ONE. 2015;10:e0139221 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:25
Endo M, de Graaff M, Ingram D, Lim S, Lev D, Briaire de Bruijn I, et al. NY-ESO-1 (CTAG1B) expression in mesenchymal tumors. Mod Pathol. 2015;28:587-95 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 1
Srivastava P, Paluch B, Matsuzaki J, James S, Collamat Lai G, Karbach J, et al. Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Leuk Res. 2014;38:1332-41 pubmed 出版商
  • 免疫组化; 人类; 表 1
Dhodapkar M, Sznol M, Zhao B, Wang D, Carvajal R, Keohan M, et al. Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Sci Transl Med. 2014;6:232ra51 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Krishnadas D, Bao L, Bai F, Chencheri S, Lucas K. Decitabine facilitates immune recognition of sarcoma cells by upregulating CT antigens, MHC molecules, and ICAM-1. Tumour Biol. 2014;35:5753-62 pubmed 出版商
  • 免疫细胞化学; 人类
Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol. 2014;192:523-32 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 5
Chen Y, Huang A, Gao M, Yan Y, Zhang W. Potential therapeutic value of dendritic cells loaded with NY?ESO?1 protein for the immunotherapy of advanced hepatocellular carcinoma. Int J Mol Med. 2013;32:1366-72 pubmed 出版商
  • 免疫组化; 人类; 图 1
Beard R, Abate Daga D, Rosati S, Zheng Z, Wunderlich J, Rosenberg S, et al. Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy. Clin Cancer Res. 2013;19:4941-50 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2
  • 免疫印迹; 人类; 图 2
Zimmermann A, Imig J, Klar A, Renner C, Korol D, Fink D, et al. Expression of MAGE-C1/CT7 and selected cancer/testis antigens in ovarian borderline tumours and primary and recurrent ovarian carcinomas. Virchows Arch. 2013;462:565-74 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1
Xu H, Gu N, Liu Z, Zheng M, Xiong F, Wang S, et al. NY-ESO-1 expression in hepatocellular carcinoma: A potential new marker for early recurrence after surgery. Oncol Lett. 2012;3:39-44 pubmed
  • 免疫组化-石蜡切片; 人类; 图 5
Schuberth P, Jakka G, Jensen S, Wadle A, Gautschi F, Haley D, et al. Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma. Gene Ther. 2013;20:386-95 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
Mazzarella T, Cambiaghi V, Rizzo N, Pilla L, Parolini D, Orsenigo E, et al. Ex vivo enrichment of circulating anti-tumor T cells from both cutaneous and ocular melanoma patients: clinical implications for adoptive cell transfer therapy. Cancer Immunol Immunother. 2012;61:1169-82 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 5
Sharma A, Bode B, Wenger R, Lehmann K, Sartori A, Moch H, et al. ?-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo. PLoS ONE. 2011;6:e28217 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 2
von Boehmer L, Keller L, Mortezavi A, Provenzano M, Sais G, Hermanns T, et al. MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer. PLoS ONE. 2011;6:e21366 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 5
Hamai A, Duperrier Amouriaux K, Pignon P, Raimbaud I, Memeo L, Colarossi C, et al. Antibody responses to NY-ESO-1 in primary breast cancer identify a subtype target for immunotherapy. PLoS ONE. 2011;6:e21129 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Bao L, Dunham K, Lucas K. MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells to facilitate cytotoxic T lymphocyte-mediated tumor cell killing. Cancer Immunol Immunother. 2011;60:1299-307 pubmed 出版商
  • 流式细胞仪; 人类; 图 s7
Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, Franzin A, et al. Immunobiological characterization of cancer stem cells isolated from glioblastoma patients. Clin Cancer Res. 2010;16:800-13 pubmed 出版商
  • 流式细胞仪; 人类; 图 4
Hu Y, Cheng S, Chan K, Ke Y, Xue B, Sin F, et al. Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells. Biochem Biophys Res Commun. 2010;392:329-34 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Tsai Turton M, Santillan A, Lu D, Bristow R, Chan K, Shih I, et al. p53 autoantibodies, cytokine levels and ovarian carcinogenesis. Gynecol Oncol. 2009;114:12-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Riener M, Wild P, Soll C, Knuth A, Jin B, Jungbluth A, et al. Frequent expression of the novel cancer testis antigen MAGE-C2/CT-10 in hepatocellular carcinoma. Int J Cancer. 2009;124:352-7 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 4
Milne K, Barnes R, Girardin A, Mawer M, Nesslinger N, Ng A, et al. Tumor-infiltrating T cells correlate with NY-ESO-1-specific autoantibodies in ovarian cancer. PLoS ONE. 2008;3:e3409 pubmed 出版商
  • 流式细胞仪; 人类; 1:500; 图 2
Knights A, Nuber N, Thomson C, de la Rosa O, Jager E, Tiercy J, et al. Modified tumour antigen-encoding mRNA facilitates the analysis of naturally occurring and vaccine-induced CD4 and CD8 T cells in cancer patients. Cancer Immunol Immunother. 2009;58:325-38 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 2a
  • 免疫细胞化学; 人类; 图 2f
Tinguely M, Jenni B, Knights A, Lopes B, Korol D, Rousson V, et al. MAGE-C1/CT-7 expression in plasma cell myeloma: sub-cellular localization impacts on clinical outcome. Cancer Sci. 2008;99:720-5 pubmed 出版商
  • 免疫印迹; 人类
Dubovsky J, Albertini M, McNeel D. MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis. J Immunother. 2007;30:675-83 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Theurillat J, Ingold F, Frei C, Zippelius A, Varga Z, Seifert B, et al. NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration. Int J Cancer. 2007;120:2411-7 pubmed
  • 免疫组化-石蜡切片; 人类; 图 2
Young M, Neville B, Chi A, Lathers D, Boyd Gillespie M, Day T. Oral premalignant lesions induce immune reactivity to both premalignant oral lesions and head and neck squamous cell carcinoma. Cancer Immunol Immunother. 2007;56:1077-86 pubmed
  • 免疫组化-石蜡切片; 人类; 图 3
Jacobs J, Brasseur F, Hulsbergen van de Kaa C, van de Rakt M, Figdor C, Adema G, et al. Cancer-germline gene expression in pediatric solid tumors using quantitative real-time PCR. Int J Cancer. 2007;120:67-74 pubmed
  • 免疫组化-石蜡切片; 人类; 1:25; 图 2C
Gjerstorff M, Johansen L, Nielsen O, Kock K, Ditzel H. Restriction of GAGE protein expression to subpopulations of cancer cells is independent of genotype and may limit the use of GAGE proteins as targets for cancer immunotherapy. Br J Cancer. 2006;94:1864-73 pubmed
  • 流式细胞仪; 人类; 图 4
Purbhoo M, Sutton D, Brewer J, Mullings R, Hill M, Mahon T, et al. Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. J Immunol. 2006;176:7308-16 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Hadrup S, Braendstrup O, Jacobsen G, Mortensen S, Pedersen L, Seremet T, et al. Tumor infiltrating lymphocytes in seminoma lesions comprise clonally expanded cytotoxic T cells. Int J Cancer. 2006;119:831-8 pubmed
  • 免疫组化-石蜡切片; 人类; 图 4
Li M, Yuan Y, Han Y, Liu Y, Yan L, Wang Y, et al. Expression profile of cancer-testis genes in 121 human colorectal cancer tissue and adjacent normal tissue. Clin Cancer Res. 2005;11:1809-14 pubmed
Pourmaleki M, Young J, Socci N, Chiang S, Edelweiss M, Li Y, et al. Extramammary Paget disease shows differential expression of B7 family members B7-H3, B7-H4, PD-L1, PD-L2 and cancer/testis antigens NY-ESO-1 and MAGE-A. Oncotarget. 2019;10:6152-6167 pubmed 出版商
Camisaschi C, Renne S, Beretta V, Rini F, Spagnuolo R, Tuccitto A, et al. Immune landscape and in vivo immunogenicity of NY-ESO-1 tumor antigen in advanced neuroblastoma patients. BMC Cancer. 2018;18:983 pubmed 出版商
Li Y, Song R, Li X, Xu F. Expression and immunogenicity of NY-ESO-1 in colorectal cancer. Exp Ther Med. 2017;13:3581-3585 pubmed 出版商
Singh N, Kulikovskaya I, Barrett D, Binder Scholl G, Jakobsen B, Martinez D, et al. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Oncoimmunology. 2016;5:e1040216 pubmed
Robbins P, Kassim S, Tran T, Crystal J, Morgan R, Feldman S, et al. A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response. Clin Cancer Res. 2015;21:1019-27 pubmed 出版商
Akcakanat A, Kanda T, Tanabe T, Komukai S, Yajima K, Nakagawa S, et al. Heterogeneous expression of GAGE, NY-ESO-1, MAGE-A and SSX proteins in esophageal cancer: Implications for immunotherapy. Int J Cancer. 2006;118:123-8 pubmed
产品信息
产品类型 :
抗体
产品名称 :
NY-ESO单克隆抗体(E978)
目录# :
35-6200
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Immunohistochemistry (Paraffin): 2.5 µg/mL, Immunohistochemistry: Assay Dependent, Western Blot: 1–3 µg/mL
物种 :
人类
克隆 :
E978
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
NY-ESO-1, a member of the CT (cancer/testis) family, is a tumor specific shared antigen with distinctive immunogenicity. The molecular basis of T cell-mediated antitumor immunity has been elucidated by the identification of a number of tumor antigens recognized by CD8+ T cells. Among these antigens, NY-ESO-1 is of particular interest because both the cytotoxic T lymphocyte and antibody have been shown to react with this antigen. The NY-ESO-1 has been detected in normal testis and in a range of human tumor types. NY-ESO-1 reactivity in testis is restricted germ cells, particularly in the spermatogonia.
免疫原 :
人类NY-ESO重组蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 2.5 µg/mL, Immunohistochemistry: Assay Dependent, Western Blot: 1–3 µg/mL
别名 :
autoimmunogenic cancer/testis antigen NY-ESO-1; Cancer/testis antigen 1; cancer/testis antigen 1A; cancer/testis antigen 1-A; cancer/testis antigen 6.1; CT6.1; CTAG; CTAG1; CTAG1A; CTAG1B; ESO1; L antigen family member 2; LAGE2; LAGE-2; LAGE2A; LAGE2B; New York Esophageal Squamous Cell Carcinoma 1; NY-ESO-1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国