| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 免疫组化-冰冻切片; 小鼠; 1:100; 图 s8a
| Zhao Q, Dai W, Chen H, Jacobs R, Zlokovic B, Lund B, et al. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022;119:e2113310119 pubmed 出版商 |
| Wei X, Meel M, Breur M, Bugiani M, Hulleman E, Phoenix T. Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas. Acta Neuropathol Commun. 2021;9:142 pubmed 出版商 |
| Orsenigo F, Conze L, Jauhiainen S, Corada M, Lazzaroni F, Malinverno M, et al. Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution. elife. 2020;9: pubmed 出版商 |
- 免疫组化-冰冻切片; 小鼠; 1:100; 图 5e
| Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed 出版商 |
| Cho C, Wang Y, Smallwood P, Williams J, Nathans J. Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers. elife. 2019;8: pubmed 出版商 |
| Wang Y, Sabbagh M, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. elife. 2019;8: pubmed 出版商 |
| Louveau A, Herz J, Alme M, Salvador A, Dong M, Viar K, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci. 2018;21:1380-1391 pubmed 出版商 |
| Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed 出版商 |
| Cho C, Smallwood P, Nathans J. Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron. 2017;95:1056-1073.e5 pubmed 出版商 |
- 免疫组化-冰冻切片; 小鼠; 1:300; 图 6k
| Andreone B, Chow B, Tata A, Lacoste B, Ben Zvi A, Bullock K, et al. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017;94:581-594.e5 pubmed 出版商 |
- 免疫组化-自由浮动切片; 小鼠; 1:400; 图 s4a
| Yanagida K, Liu C, Faraco G, Galvani S, Smith H, Burg N, et al. Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017;114:4531-4536 pubmed 出版商 |
- 免疫组化-冰冻切片; 小鼠; 1:100; 图 5b
| Swanson P, Hart G, Russo M, Nayak D, Yazew T, Pena M, et al. CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature. PLoS Pathog. 2016;12:e1006022 pubmed 出版商 |
- 免疫组化; 人类; 图 1
- 免疫组化; 小鼠; 图 1
| Lewandowski S, Nilsson I, Fredriksson L, Lönnerberg P, Muhl L, Zeitelhofer M, et al. Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration. Acta Neuropathol. 2016;131:453-64 pubmed 出版商 |
| Zhou Y, Williams J, Smallwood P, Nathans J. Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS ONE. 2015;10:e0143650 pubmed 出版商 |
| Hyun Jo D, Lee R, Hyoung Kim J, Oh Jun H, Geol Lee T, Hun Kim J. Real-time estimation of paracellular permeability of cerebral endothelial cells by capacitance sensor array. Sci Rep. 2015;5:11014 pubmed 出版商 |
- 免疫组化-冰冻切片; 小鼠; 1:200; 图 e5
| Louveau A, Smirnov I, Keyes T, Eccles J, Rouhani S, Peske J, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523:337-41 pubmed 出版商 |
| Rattner A, Wang Y, Zhou Y, Williams J, Nathans J. The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling. Invest Ophthalmol Vis Sci. 2014;55:8614-25 pubmed 出版商 |
| Zhou Y, Wang Y, TISCHFIELD M, Williams J, Smallwood P, Rattner A, et al. Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest. 2014;124:3825-46 pubmed 出版商 |
| Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, et al. EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature. 2013;498:492-6 pubmed 出版商 |
| Wang Y, Rattner A, Zhou Y, Williams J, Smallwood P, Nathans J. Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity. Cell. 2012;151:1332-44 pubmed 出版商 |
| Le T, Nguyen T, Kalailingam P, Nguyen Y, Sukumar V, Tan C, et al. Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock. Cell Rep. 2022;40:111208 pubmed 出版商 |
| Greene C, Campbell M. Immunohistochemical Analysis of Tight Junction Proteins. Methods Mol Biol. 2022;2492:307-314 pubmed 出版商 |
| Ayloo S, Lazo C, Sun S, Zhang W, Cui B, Gu C. Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier. Neuron. 2022;110:1641-1655.e6 pubmed 出版商 |
| Boyé K, Geraldo L, Furtado J, Pibouin Fragner L, Poulet M, Kim D, et al. Endothelial Unc5B controls blood-brain barrier integrity. Nat Commun. 2022;13:1169 pubmed 出版商 |
| Engelbrecht E, Metzler M, Sandell L. Retinoid signaling regulates angiogenesis and blood-retinal barrier integrity in neonatal mouse retina. Microcirculation. 2022;29:e12752 pubmed 出版商 |
| Song X, Cui Y, Wang Y, Zhang Y, He Q, Yu Z, et al. Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells. Int J Biol Sci. 2022;18:652-660 pubmed 出版商 |
| Ivanova E, Corona C, Eleftheriou C, Stout R, K xf6 rbelin J, Sagdullaev B. AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43. J Comp Neurol. 2022;530:1302-1317 pubmed 出版商 |
| Yu R, Kim N, Li Y, Jeong J, Park S, Zhou B, et al. Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Transl Stroke Res. 2022;13:142-159 pubmed 出版商 |
| Amiri P, DeCastro J, Littig J, Lu H, Liu C, Conboy I, et al. Erythrocytes, a New Contributor to Age-Associated Loss of Blood-Brain Barrier Integrity. Adv Sci (Weinh). 2021;8:e2101912 pubmed 出版商 |
| Holzner S, Bromberger S, Wenzina J, Neumüller K, Holper T, Petzelbauer P, et al. Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells. J Cell Sci. 2021;: pubmed 出版商 |
| Chidiac R, Abedin M, Macleod G, Yang A, Thibeault P, Blazer L, et al. A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Mol Med. 2021;13:e13977 pubmed 出版商 |
| Dani N, Herbst R, McCabe C, Green G, Kaiser K, Head J, et al. A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021;184:3056-3074.e21 pubmed 出版商 |
| Marquez Curtis L, Bokenfohr R, McGann L, Elliott J. Cryopreservation of human cerebral microvascular endothelial cells and astrocytes in suspension and monolayers. PLoS ONE. 2021;16:e0249814 pubmed 出版商 |
| Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, et al. Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability. Cardiovasc Res. 2021;117:533-546 pubmed 出版商 |
| Yang J, Ma K, Zhang C, Liu Y, Liang F, Hu W, et al. Burns Impair Blood-Brain Barrier and Mesenchymal Stem Cells Can Reverse the Process in Mice. Front Immunol. 2020;11:578879 pubmed 出版商 |
| Cottarelli A, Corada M, Beznoussenko G, Mironov A, Globisch M, Biswas S, et al. Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development. 2020;147: pubmed 出版商 |
| Ittner C, Burek M, Störk S, Nagai M, Förster C. Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro. Front Cardiovasc Med. 2020;7:73 pubmed 出版商 |
| Lehmann G, Hanke Gogokhia C, Hu Y, Bareja R, Salfati Z, Ginsberg M, et al. Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid. J Exp Med. 2020;217: pubmed 出版商 |
| Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, et al. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020;52:779-793.e7 pubmed 出版商 |
| Wang Y, Smallwood P, Williams J, Nathans J. A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Hum Mol Genet. 2020;29:1121-1131 pubmed 出版商 |
| Lee S, Chung M, Lee S, Jeon N. 3D brain angiogenesis model to reconstitute functional human blood-brain barrier in vitro. Biotechnol Bioeng. 2020;117:748-762 pubmed 出版商 |
| Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann Y, Kanekiyo T, et al. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arterioscler Thromb Vasc Biol. 2020;40:128-144 pubmed 出版商 |
| Lux T, Hu X, Ben Kraiem A, Blum R, Chen J, Rittner H. Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats. Int J Mol Sci. 2019;21: pubmed 出版商 |
| Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, et al. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell. 2019;25:754-767.e9 pubmed 出版商 |
| Meel M, Guillen Navarro M, de Gooijer M, Metselaar D, Waranecki P, Breur M, et al. MEK/MELK inhibition and blood-brain barrier-deficiencies in atypical teratoid/rhabdoid tumors. Neuro Oncol. 2019;: pubmed 出版商 |
| Suwannasual U, Lucero J, Davis G, McDonald J, Lund A. Mixed Vehicle Emissions Induces Angiotensin II and Cerebral Microvascular Angiotensin Receptor Expression in C57Bl/6 Mice and Promotes Alterations in Integrity in a Blood-Brain Barrier Coculture Model. Toxicol Sci. 2019;170:525-535 pubmed 出版商 |
| Niu J, Tsai H, Hoi K, Huang N, Yu G, Kim K, et al. Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. Nat Neurosci. 2019;22:709-718 pubmed 出版商 |
| Ivanova E, Alam N, Prusky G, Sagdullaev B. Blood-retina barrier failure and vision loss in neuron-specific degeneration. JCI Insight. 2019;5: pubmed 出版商 |
| Patel M, Behar A, Silasi R, Regmi G, Sansam C, Keshari R, et al. Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. J Am Heart Assoc. 2018;7:e010690 pubmed 出版商 |
| Wang Y, Cho C, Williams J, Smallwood P, Zhang C, Junge H, et al. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018;115:E11827-E11836 pubmed 出版商 |
| Zbesko J, Nguyen T, Yang T, Frye J, Hussain O, Hayes M, et al. Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts. Neurobiol Dis. 2018;112:63-78 pubmed 出版商 |
| Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed 出版商 |
| Ivanova E, Kovacs Oller T, Sagdullaev B. Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy. J Neurosci. 2017;37:7580-7594 pubmed 出版商 |
| Chow B, Gu C. Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation. Neuron. 2017;93:1325-1333.e3 pubmed 出版商 |
| Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro Oonuma T, Hwang Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2017;2:e90905 pubmed 出版商 |
| Paul D, Baena V, Ge S, Jiang X, Jellison E, Kiprono T, et al. Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. J Neuroinflammation. 2016;13:292 pubmed |
| Zhou Y, Nathans J. Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling. Dev Cell. 2014;31:248-56 pubmed 出版商 |
| Wu H, Luo J, Yu H, Rattner A, Mo A, Wang Y, et al. Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease. Neuron. 2014;81:103-19 pubmed 出版商 |
| Chen J, Stahl A, Krah N, Seaward M, Dennison R, Sapieha P, et al. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011;124:1871-81 pubmed 出版商 |
