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抗体

磷酸化酪氨酸羟化酶(Ser31)多克隆抗体

36-9900

100微升

美国375.00

多克隆

domestic rabbit

未共轭

磷酸化

免疫印迹, 免疫组化, 免疫细胞化学

磷酸化酪氨酸羟化酶(Ser31)多克隆抗体

36-9900

100微升

美国375.00

多克隆

亲和色谱

兔

大鼠

Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

大鼠

IgG

-20°C

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Synthetic phospho peptide derived from a region of the rat tyrosine hydroxylase (TH) protein surrounding the phosphorylated Ser31 residue.

液体

Immunocytochemistry: 1:1,000, Immunohistochemistry: 1:1,000, Western Blot: 1:1,000

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase