产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EphA4单克隆抗体(4C8H5)
目录 :
37-1600
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4C8H5
反应物种 :
人类, 小鼠, 鸡
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 25
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:250; 图 10a
Matsuura K, Kobayashi S, Konno K, Yamasaki M, Horiuchi T, Senda T, et al. SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling. J Neurosci. 2022;42:2448-2473 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
TerBush A, Hafkamp F, Lee H, Coscoy L. A Kaposi's Sarcoma-Associated Herpesvirus Infection Mechanism Is Independent of Integrins α3β1, αVβ3, and αVβ5. J Virol. 2018;92: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Rothe M, Kanwal N, Dietmann P, Seigfried F, Hempel A, Schütz D, et al. An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development. 2017;144:321-333 pubmed 出版商
  • 免疫沉淀; 人类; 图 4a
  • 免疫印迹; 人类; 图 4a
Jurek A, Genander M, Kundu P, Catchpole T, He X, Strååt K, et al. Eph receptor interclass cooperation is required for the regulation of cell proliferation. Exp Cell Res. 2016;348:10-22 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200
Joly S, Jordi N, Schwab M, Pernet V. The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve. Eur J Neurosci. 2014;40:3021-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 3
Kempf A, Montani L, Petrinovic M, Schroeter A, Weinmann O, Patrignani A, et al. Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration. Eur J Neurosci. 2013;38:3567-79 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2
Lemmens R, Jaspers T, Robberecht W, Thijs V. Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke. Hum Mol Genet. 2013;22:2214-20 pubmed 出版商
  • 免疫组化; 小鼠
Semerdjieva S, Abdul Razak H, Salim S, Yáñez Muñoz R, Chen P, Tarabykin V, et al. Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors. Mol Cell Biol. 2013;33:1442-55 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4
Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats K, Laird A, et al. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med. 2012;18:1418-22 pubmed
  • 免疫沉淀; 小鼠; 图 5
Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, et al. Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS ONE. 2008;3:e3322 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Beg A, Sommer J, Martin J, Scheiffele P. alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007;55:768-78 pubmed
Liang X, Fa W, Wang N, Peng Y, Liu C, Zhu M, et al. Exosomal miR-532-5p induced by long-term exercise rescues blood-brain barrier function in 5XFAD mice via downregulation of EPHA4. Aging Cell. 2023;22:e13748 pubmed 出版商
Dennys C, Baggio C, Rodrigo R, Roussel F, Kulinich A, Heintzman S, et al. EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes. iScience. 2022;25:104877 pubmed 出版商
Baggio C, Kulinich A, Dennys C, Rodrigo R, Meyer K, ETHELL I, et al. NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. J Med Chem. 2021;64:11229-11246 pubmed 出版商
Poppe L, Rue L, Timmers M, Lenaerts A, Storm A, Callaerts Vegh Z, et al. EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2019;11:102 pubmed 出版商
de Boer A, Storm A, Gómez Soler M, Smolders S, Rue L, Poppe L, et al. Environmental enrichment during the chronic phase after experimental stroke promotes functional recovery without synergistic effects of EphA4 targeted therapy. Hum Mol Genet. 2020;29:605-617 pubmed 出版商
Poppe L, Smolders S, Rue L, Timmers M, Lenaerts A, Storm A, et al. Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy. Front Neurosci. 2019;13:1233 pubmed 出版商
Kowalski E, Chen J, Hazy A, Fritsch L, Gudenschwager Basso E, Chen M, et al. Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage. J Neuroinflammation. 2019;16:210 pubmed 出版商
Rue L, Timmers M, Lenaerts A, Smolders S, Poppe L, de Boer A, et al. Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis. Sci Rep. 2019;9:14112 pubmed 出版商
García Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 2019;: pubmed 出版商
Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White B, Jardetzky T, et al. Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus. Nat Microbiol. 2018;3:172-180 pubmed 出版商
Wu B, De S, Kulinich A, Salem A, Koeppen J, Wang R, et al. Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol. 2017;24:293-305 pubmed 出版商
Roher A, Maarouf C, Kokjohn T, Whiteside C, Kalback W, Serrano G, et al. Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat. Am J Neurodegener Dis. 2014;3:115-33 pubmed
Noberini R, Rubio de la Torre E, Pasquale E. Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach. Cell Adh Migr. 2012;6:102-12 pubmed 出版商
Richter M, Murai K, Bourgin C, Pak D, Pasquale E. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci. 2007;27:14205-15 pubmed
产品信息
产品类型 :
抗体
产品名称 :
EphA4单克隆抗体(4C8H5)
目录# :
37-1600
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
鸡, 人类, 小鼠
应用 :
ELISA: Assay-dependent, Immunohistochemistry: 3-10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
物种 :
鸡, 人类, 小鼠
克隆 :
4C8H5
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.
免疫原 :
A synthetic peptide derived from the C-terminus human EphA4 receptor protein.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunohistochemistry: 3-10 µg/mL, Immunoprecipitation: 5 µg, Western Blot: 1-3 µg/mL
别名 :
2900005C20Rik; AI385584; Cek8; Cek8 protein; EK8; epa4; EPH receptor A4; Epha4; EPH-like kinase 8; Ephrin type-A receptor 4; Hek8; rb; receptor protein-tyrosine kinase HEK8; RGD1560587; Sek; Sek1; Tyro1; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor SEK; tyrosine-protein kinase receptor SEK-1; Tyrosine-protein kinase TYRO1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国