产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
BTRC单克隆抗体(1B1D2)
目录 :
37-3400
规格 :
100微克
价格 :
美国430.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1B1D2
反应物种 :
人类, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1l
Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Kim T, Siesser P, Rossman K, Goldfarb D, Mackinnon K, Yan F, et al. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol. 2015;35:167-81 pubmed 出版商
  • 免疫印迹; 人类
Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, et al. PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS ONE. 2014;9:e110296 pubmed 出版商
  • 免疫印迹; 人类
Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Siesser P, Motolese M, Walker M, Goldfarb D, Gewain K, Yan F, et al. FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. Sci Signal. 2012;5:ra64 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Su J, Cheng X, Yamaguchi H, Chang Y, Hou C, Lee D, et al. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011;71:6878-87 pubmed 出版商
  • 免疫印迹; 人类
Tian Y, Kolb R, Hong J, Carroll J, Li D, You J, et al. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007;27:6383-95 pubmed
Long B, Yang X, Xu X, Li X, Xu X, Zhang X, et al. Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR. Cell Death Dis. 2020;11:995 pubmed 出版商
Vind A, Snieckute G, Blasius M, Tiedje C, Krogh N, Bekker Jensen D, et al. ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains. Mol Cell. 2020;78:700-713.e7 pubmed 出版商
Lan Y, Xiao X, He Z, Luo Y, Wu C, Li L, et al. Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Res. 2018;46:5809-5821 pubmed 出版商
Kang D, Lee D, Lee S, Lee S, Jun Y, Kim Y, et al. Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. Nat Commun. 2017;8:40 pubmed 出版商
Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed 出版商
Tseng R, Chang J, Mao J, Tsai C, Wu P, Lin C, et al. Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer. Oncotarget. 2015;6:44207-21 pubmed 出版商
Hsu K, Kao H. ?-Transducin repeat-containing protein 1 (?-TrCP1)-mediated silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) protein degradation promotes tumor necrosis factor ? (TNF?)-induced inflammatory gene expression. J Biol Chem. 2013;288:25375-86 pubmed 出版商
Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al. mTOR drives its own activation via SCF(?TrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011;44:290-303 pubmed 出版商
Kato T, Mizuno S, Nakamura T. Preservations of nephrin and synaptopodin by recombinant hepatocyte growth factor in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice. Nephrology (Carlton). 2011;16:310-8 pubmed 出版商
Rada P, Rojo A, Chowdhry S, McMahon M, Hayes J, Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol. 2011;31:1121-33 pubmed 出版商
Thomas Y, Coux O, Baldin V. βTrCP-dependent degradation of CDC25B phosphatase at the metaphase-anaphase transition is a pre-requisite for correct mitotic exit. Cell Cycle. 2010;9:4338-50 pubmed
Lin R, Hsieh Y, Lin P, Hsu H, Chen C, Tang Y, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest. 2010;120:521-32 pubmed 出版商
Westbrook T, Hu G, Ang X, Mulligan P, Pavlova N, Liang A, et al. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008;452:370-4 pubmed 出版商
Mailand N, Bekker Jensen S, Bartek J, Lukas J. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell. 2006;23:307-18 pubmed
产品信息
产品类型 :
抗体
产品名称 :
BTRC单克隆抗体(1B1D2)
目录# :
37-3400
规格 :
100微克
价格 :
美国430.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 大鼠
应用 :
ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
人类, 大鼠
克隆 :
1B1D2
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
免疫原 :
重组人类乙TrCP融合蛋白
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
beta-transducin repeat containing E3 ubiquitin protein ligase; beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; betaTrCP; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; Btrc; BTRCP; b-TrCP; bTrCP1; E3RSIkappaB; E3RS-IkappaB; epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A; mE3RS-IkappaB; pIkappaBalpha-E3 receptor subunit; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; Ubiquitin ligase FWD1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国