产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EphA2单克隆抗体(1C11A12)
目录 :
37-4400
规格 :
100微克
价格 :
美国500.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1C11A12
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 11
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 1:100; 图 3
  • 免疫细胞化学; 人类; 1:100; 图 s1
Lee H, Noh H, Mun J, Gu C, Sever S, Park S. Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. Nat Commun. 2016;7:12799 pubmed 出版商
  • 免疫组化; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Lee J, Han H, Shahzad M, Kim S, Mangala L, Nick A, et al. EphA2 immunoconjugate as molecularly targeted chemotherapy for ovarian carcinoma. J Natl Cancer Inst. 2009;101:1193-205 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 3
Damschroder M, Widjaja L, Gill P, Krasnoperov V, Jiang W, Dall Acqua W, et al. Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties. Mol Immunol. 2007;44:3049-60 pubmed
Prakash P, Kruse A, Vogel C, Schagdarsurengin U, Wagenlehner F. Targeting Host Tyrosine Kinase Receptor EPHA2 Signaling Affects Uropathogen Infection in Human Bladder Epithelial Cells. Pathogens. 2022;11: pubmed 出版商
Kaminskyy V, Haag P, Novak M, Vegvari A, Arapi V, Lewensohn R, et al. EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells. Cancers (Basel). 2021;13: pubmed 出版商
Liu B, Sun W, Gao W, Li L, Cao Z, Yang X, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019 pubmed 出版商
Salem A, Wang S, Billet S, Chen J, Udompholkul P, Gambini L, et al. Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate. J Med Chem. 2018;61:2052-2061 pubmed 出版商
Pewkliang Y, Rungin S, Lerdpanyangam K, Duangmanee A, Kanjanasirirat P, Suthivanich P, et al. A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax. Malar J. 2018;17:50 pubmed 出版商
Efazat G, Novak M, Kaminskyy V, De Petris L, Kanter L, Juntti T, et al. Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer. Oncotarget. 2016;7:60332-60347 pubmed 出版商
Prigozhina N, Heisel A, Wei K, Noberini R, Hunter E, Calzolari D, et al. Characterization of a novel angiogenic model based on stable, fluorescently labelled endothelial cell lines amenable to scale-up for high content screening. Biol Cell. 2011;103:467-81 pubmed 出版商
Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, et al. A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer Res. 2008;68:9367-74 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
EphA2单克隆抗体(1C11A12)
目录# :
37-4400
规格 :
100微克
价格 :
美国500.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
1C11A12
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
免疫原 :
Synthetic peptide derived from the C-terminal region of the human EphA2 Receptor protein.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: 2 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 µg/mL
别名 :
ARCC2; AW545284; CTPA; CTPP1; CTRCT6; Eck; EPH receptor A2; Epha2; ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; I79_019726; Myk2; Sek2; Sek-2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国