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抗体

SOCS3单克隆抗体(1B2)

37-7200

100微克

美国430.00

单克隆

小鼠

未共轭

1B2

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 流式细胞仪

SOCS3单克隆抗体(1B2)

37-7200

100微克

美国430.00

单克隆

蛋白质A

小鼠

人类, 小鼠

ELISA: Assay-dependent, Western Blot: Assay-dependent

人类, 小鼠

1B2

IgG1, kappa

-20°C

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Synthetic peptide derived from the N-terminal region of the mouse SOCS-3 protein

液体

ELISA: Assay-dependent, Western Blot: Assay-dependent

ATOD4; CIS3; CIS-3; Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; Ef10; EF-10; MGC71791; Protein EF-10; Socs3; Socs-3; SSI3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3