产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IRF3单克隆抗体(17C2)
目录 :
39-2700
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
17C2
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 2
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 图 2
  • 免疫印迹; 小鼠; 图 2
Konno H, Konno K, Barber G. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell. 2013;155:688-98 pubmed 出版商
Spiegel M, Pichlmair A, Martinez Sobrido L, Cros J, Garcia Sastre A, Haller O, et al. Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. J Virol. 2005;79:2079-86 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IRF3单克隆抗体(17C2)
目录# :
39-2700
规格 :
100微克
价格 :
375美元
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Western Blot: Assay Dependent
物种 :
人类
克隆 :
17C2
抗体亚型 :
IgG2a
储存 :
-20°C
描述 :
IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.
免疫原 :
Recombinant protein derived from the C-terminal region of the human IRF3 (interferon regulatory factor 3) protein
格式 :
液体
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay Dependent, Western Blot: Assay Dependent
别名 :
C920001K05Rik;IIAE7;干扰素调节因子3;Irf3;IRF-3;IRF3(磷酸化S386);IRF3(pS386);IRF3(pSer386);IRF3磷酸化;IRF3磷酸化S386;IRF3磷酸化Ser386;磷酸化IRF3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国