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NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
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豚鼠, 人类, 小鼠, , pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
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文章摘录数: 60
  • 免疫印迹; 人类; 1:500; 图 2h
Herold N, Rudd S, Ljungblad L, Sanjiv K, Myrberg I, Paulin C, et al. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nat Med. 2017;23:256-263 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 1
Skrdlant L, Stark J, Lin R. Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C. BMC Mol Biol. 2016;17:18 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Maza P, Suzuki E. Histoplasma capsulatum-Induced Cytokine Secretion in Lung Epithelial Cells Is Dependent on Host Integrins, Src-Family Kinase Activation, and Membrane Raft Recruitment. Front Microbiol. 2016;7:580 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Ortuno D, Carlisle H, Miller S. Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?. F1000Res. 2016;5:137 pubmed 出版商
  • 免疫印迹; 豚鼠; 1:1000; 图 7
Álvarez Santos M, Carbajal V, Tellez Jiménez O, Martínez Cordero E, Ruiz V, Hernández Pando R, et al. Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of β1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation. J Cell Biochem. 2016;117:2385-96 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Albrecht I, Wick C, Hallgren Ã, Tjärnlund A, Nagaraju K, Andrade F, et al. Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J Clin Invest. 2015;125:4612-24 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 1a
Barros B, Maza P, Alcantara C, Suzuki E. Paracoccidioides brasiliensis induces recruitment of α3 and α5 integrins into epithelial cell membrane rafts, leading to cytokine secretion. Microbes Infect. 2016;18:68-77 pubmed 出版商
  • 免疫印迹; 人类; 1:5000
Zhao Y, Zhao L, Wang P, Miao Y, Liu Y, Wang Z, et al. Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin. J Neurosci Res. 2015;93:1891-902 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Chesarino N, McMichael T, Yount J. E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 2015;11:e1005095 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2016;35:1926-42 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Verma S, Mohapatra G, Ahmad S, Rana S, Jain S, Khalsa J, et al. Salmonella Engages Host MicroRNAs To Modulate SUMOylation: a New Arsenal for Intracellular Survival. Mol Cell Biol. 2015;35:2932-46 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Coudé M, Braun T, Berrou J, Dupont M, Bertrand S, Massé A, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015;6:17698-712 pubmed
  • 免疫印迹; 人类; 1:10000
Å talekar M, Yin X, Rebolj K, Darovic S, Troakes C, Mayr M, et al. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015;293:157-70 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Maarouf C, Kokjohn T, Walker D, Whiteside C, Kalback W, Whetzel A, et al. Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease. PLoS ONE. 2014;9:e105784 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Calabro S, Maczurek A, Morgan A, Tu T, Wen V, Yee C, et al. Hepatocyte produced matrix metalloproteinases are regulated by CD147 in liver fibrogenesis. PLoS ONE. 2014;9:e90571 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 4c
Ni Z, Xu C, Guo X, Hunter G, Kuznetsova O, Tempel W, et al. RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat Struct Mol Biol. 2014;21:686-695 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Olenich S, Audet G, Roberts K, Olfert I. Effects of detraining on the temporal expression of positive and negative angioregulatory proteins in skeletal muscle of mice. J Physiol. 2014;592:3325-38 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2
Chesarino N, McMichael T, Hach J, Yount J. Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J Biol Chem. 2014;289:11986-92 pubmed 出版商
  • 免疫印迹; 人类; 1:10000; 图 s1
Shtam T, Kovalev R, Varfolomeeva E, Makarov E, Kil Y, Filatov M. Exosomes are natural carriers of exogenous siRNA to human cells in vitro. Cell Commun Signal. 2013;11:88 pubmed 出版商
  • 免疫印迹; 犬; 图 7
Kyöstilä K, Lappalainen A, Lohi H. Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10. PLoS ONE. 2013;8:e75621 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Shimojo M, Shudo Y, Ikeda M, Kobashi T, Ito S. The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100). Mol Cancer Res. 2013;11:1258-68 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Li L, Sarver A, Alamgir S, Subramanian S. Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma. Lab Invest. 2012;92:571-83 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 6
Liikanen I, Dias J, Nokisalmi P, Sloniecka M, Kangasniemi L, Rajecki M, et al. Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo. Int J Radiat Oncol Biol Phys. 2010;78:1201-9 pubmed 出版商
  • 免疫印迹; 人类; 1:15,000
Spatara M, Robinson A. Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction. J Neurosci Res. 2010;88:1951-61 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Fang F, Rycyzyn M, Clevenger C. Role of c-Myb during prolactin-induced signal transducer and activator of transcription 5a signaling in breast cancer cells. Endocrinology. 2009;150:1597-606 pubmed 出版商
  • 免疫印迹; pigs ; 图 6
Prunier F, Kawase Y, Gianni D, Scapin C, Danik S, Ellinor P, et al. Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation. 2008;118:614-24 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Nguyen T, Galvan V, Huang W, Banwait S, Tang H, Zhang J, et al. Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664. J Neurochem. 2008;104:1065-80 pubmed
Povo Retana A, Mojena M, Stremtan A, Fernández García V, Gómez Sáez A, Nuevo Tapioles C, et al. Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights. Cancers (Basel). 2020;12: pubmed 出版商
Lima K, Schneider Levorse V, Rosa Garcia M, de Souza Basso B, Pasqualotto Costa B, Antunes G, et al. Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-gamma gene expression. EXCLI J. 2020;19:962-971 pubmed 出版商
Nguyen A, Koeppen J, Woodruff S, Mina K, Figueroa Z, Ethell I. Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory. Front Synaptic Neurosci. 2020;12:10 pubmed 出版商
Richter A, Sender S, Lenz A, Schwarz R, Hinz B, Knuebel G, et al. Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo. BMC Cancer. 2020;20:184 pubmed 出版商
Wang X, Williams D, Muller I, Lemieux M, Dukart R, Maia I, et al. Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins. Sci Rep. 2019;9:16238 pubmed 出版商
Che S, Bie L, Li X, Qi H, Yu P, Zuo L. Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells. Int J Ophthalmol. 2019;12:1531-1538 pubmed 出版商
Xu S, Lun Y, Frascella M, Garcia A, Soska R, Nair A, et al. Improved efficacy of a next-generation ERT in murine Pompe disease. JCI Insight. 2019;4: pubmed 出版商
Roca Lema D, Martínez Iglesias O, Fernández de Ana Portela C, Rodríguez Blanco A, Valladares Ayerbes M, Díaz Díaz A, et al. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells. Int J Med Sci. 2019;16:231-240 pubmed 出版商
Chavez J, Vargas M, Martínez Zúñiga J, Falfan Valencia R, Ambrocio Ortiz E, Carbajal V, et al. Allergic sensitization increases the amount of extracellular ATP hydrolyzed by guinea pig leukocytes. Purinergic Signal. 2019;15:69-76 pubmed 出版商
Mohapatra G, Gaur P, Mujagond P, Singh M, Rana S, Pratap S, et al. A SUMOylation-dependent switch of RAB7 governs intracellular life and pathogenesis of Salmonella Typhimurium. J Cell Sci. 2019;132: pubmed 出版商
Adam I, Dewi D, Mooiweer J, Sadik A, Mohapatra S, Berdel B, et al. Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. Oncoimmunology. 2018;7:e1486353 pubmed 出版商
Yuliantie E, Dai X, Yang D, Crack P, Wang M. High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway. Acta Pharm Sin B. 2018;8:889-899 pubmed 出版商
Rubtsova M, Naraykina Y, Vasilkova D, Meerson M, Zvereva M, Prassolov V, et al. Protein encoded in human telomerase RNA is involved in cell protective pathways. Nucleic Acids Res. 2018;46:8966-8977 pubmed 出版商
Kock A, Larsson K, Bergqvist F, Eissler N, Elfman L, Raouf J, et al. Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth. EBioMedicine. 2018;32:84-92 pubmed 出版商
Koeppen J, Nguyen A, Nikolakopoulou A, Garcia M, Hanna S, Woodruff S, et al. Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus. J Neurosci. 2018;38:5710-5726 pubmed 出版商
Kurata J, Lin R. MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs. RNA. 2018;24:966-981 pubmed 出版商
Suman P, Mishra S, Chander H. High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. Med Oncol. 2018;35:71 pubmed 出版商
Zhang Y, Zhang Y. Forkhead box C2 promotes the invasion ability of human trophoblast cells through Hedgehog (Hh) signaling pathway. Cell Biol Int. 2018;42:859-866 pubmed 出版商
Lee A, De Mei C, Fereira M, Marotta R, Yoon H, Kim K, et al. Dexamethasone-loaded Polymeric Nanoconstructs for Monitoring and Treating Inflammatory Bowel Disease. Theranostics. 2017;7:3653-3666 pubmed 出版商
Chesarino N, Compton A, McMichael T, Kenney A, Zhang L, Soewarna V, et al. IFITM3 requires an amphipathic helix for antiviral activity. EMBO Rep. 2017;18:1740-1751 pubmed 出版商
Panda D, Saha P, Das T, Dash J. Target guided synthesis using DNA nano-templates for selectively assembling a G-quadruplex binding c-MYC inhibitor. Nat Commun. 2017;8:16103 pubmed 出版商
Irimia J, Meyer C, Segvich D, Surendran S, DePaoli Roach A, Morral N, et al. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem. 2017;292:10455-10464 pubmed 出版商
Dewi D, Mohapatra S, Blanco Cabañes S, Adam I, Somarribas Patterson L, Berdel B, et al. Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology. 2017;6:e1274477 pubmed 出版商
Gemel J, Levy A, Simon A, Bennett K, Ai X, AKHTER S, et al. Connexin40 abnormalities and atrial fibrillation in the human heart. J Mol Cell Cardiol. 2014;76:159-68 pubmed 出版商
Roher A, Maarouf C, Malek Ahmadi M, Wilson J, Kokjohn T, Daugs I, et al. Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations. Am J Neurodegener Dis. 2013;2:187-207 pubmed
Olenich S, Gutierrez Reed N, Audet G, Olfert I. Temporal response of positive and negative regulators in response to acute and chronic exercise training in mice. J Physiol. 2013;591:5157-69 pubmed 出版商
Botta G, Reginato M, Reichert M, Rustgi A, Lelkes P. Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1. Mol Cancer Res. 2012;10:183-96 pubmed 出版商
Paschoud S, Yu D, Pulimeno P, Jond L, Turner J, Citi S. Cingulin and paracingulin show similar dynamic behaviour, but are recruited independently to junctions. Mol Membr Biol. 2011;28:123-35 pubmed 出版商
Gianni D, Li A, Tesco G, McKay K, Moore J, Raygor K, et al. Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation. 2010;121:1216-26 pubmed 出版商
Leonardi R, Almeida L, Trevilatto P, Loreto C. Occurrence and regional distribution of TRAIL and DR5 on temporomandibular joint discs: comparison of disc derangement with and without reduction. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:244-51 pubmed 出版商
White L, Declercq W, Arfuso F, Charles A, Dharmarajan A. Function of caspase-14 in trophoblast differentiation. Reprod Biol Endocrinol. 2009;7:98 pubmed 出版商
Wang Y, Mulligan C, Denyer G, Delom F, Dagna Bricarelli F, Tybulewicz V, et al. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics. 2009;8:585-95 pubmed 出版商
Fang F, Antico G, Zheng J, Clevenger C. Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter. BMC Biotechnol. 2008;8:11 pubmed 出版商
产品类型 :
产品名称 :
目录# :
规格 :
价格 :
克隆性 :
纯度 :
宿主 :
反应物种 :
人类, 小鼠
应用 :
ELISA: Assay Dependent, Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 0.5-2 µg/mL
物种 :
人类, 小鼠
克隆 :
抗体亚型 :
IgG1, kappa
储存 :
描述 :
GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.
免疫原 :
格式 :
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: 1-2 µg/mL, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 0.5-2 µg/mL
别名 :
38 kDa BFA-dependent ADP-ribosylation substrate; aging-associated gene 9 protein; BARS-38; bb02e05; cb350; cb609; CDABP0047; EC; epididymis secretory protein Li 278; epididymis secretory sperm binding protein Li 162eP; fb71f08; fk58c09; G3PD; G3PDH; Gapd; GAPD2; gapdh; GAPDH2; GAPDH-2; GAPDHS; GAPDS; Gapd-s; glyceraldehyde 3-phosphate dehydrogenase; glyceraldehyde 3-phosphate dehydrogenase, testis-specific; glyceraldehyde phosphate dehydrogenase; glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase 2; glyceraldehyde-3-phosphate dehydrogenase GAPDH; glyceraldehyde-3-phosphate dehydrogenase like-17 protein; glyceraldehyde-3-phosphate dehydrogenase type 2; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; glyceraldehyde-phosphate-dehydrogenase; glycerine aldehyde 3-phosphate dehydrogenase; HEL-S-162eP; HEL-S-278; HGNC:4141; HSD35; HSD-35; I79_001391; KNC-NDS6; LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase, testis-specific; mg:bb02e05; MGC128279 protein; MGC88685; OK/SW-cl.12; Peptidyl-cysteine S-nitrosylase GAPDH; similar to glyceraldehyde 3-phosphate dehydrogenase; spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase; Unknown (protein for IMAGE:8101613); wu:fb33a10; wu:fb71f08; wu:fk58c09; wu:ft80f05; zgc:76908
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公司总部: 美国