产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PCDGF多克隆抗体
目录 :
40-3400
规格 :
100微克
价格 :
美国450.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 人类; 图 4a
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022;41:e109108 pubmed 出版商
  • 免疫印迹; 人类; 图 9f
Suzuki H, Matsuoka M. The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death. J Biol Chem. 2016;291:21448-21460 pubmed
Zhao X, Hasan S, Liou B, Lin Y, Sun Y, Liu C. Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice. Int J Mol Sci. 2022;23: pubmed 出版商
Zhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, et al. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. J Mol Med (Berl). 2021;99:1639-1654 pubmed 出版商
Gururaj S, Sampognaro P, Argouarch A, Kao A. Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics. Front Neurosci. 2020;14:602235 pubmed 出版商
Arrant A, Roth J, Boyle N, Kashyap S, Hoffmann M, Murchison C, et al. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta Neuropathol Commun. 2019;7:218 pubmed 出版商
Holler C, Taylor G, Deng Q, Kukar T. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Eneuro. 2017;4: pubmed 出版商
She A, Kurtser I, Reis S, Hennig K, Lai J, Lang A, et al. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia. Cell Chem Biol. 2017;24:892-906.e5 pubmed 出版商
Henry C, Sullivan G, Clancy D, Afonina I, Kulms D, Martin S. Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines. Cell Rep. 2016;14:708-722 pubmed 出版商
Yeh J, Kreimer S, Walker S, Emori M, Krystal H, Richardson A, et al. Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. Genes Cancer. 2015;6:153-68 pubmed
产品信息
产品类型 :
抗体
产品名称 :
PCDGF多克隆抗体
目录# :
40-3400
规格 :
100微克
价格 :
美国450.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类
应用 :
Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
免疫原 :
Synthetic peptide derived from the C-terminal region of human PCDGF
格式 :
液体
应用w/稀释 :
Immunoprecipitation: Assay-dependent, Western Blot: Assay-dependent
别名 :
Acrogranin; CLN11; Epithelin precursor; Epithelin-1; Epithelin-2; GEP; Glycoprotein of 88 Kda; GP88; granulin; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; granulin-epithelin; granulins; GRN; Paragranulin; PC cell-derived growth factor; PCDGF; PEPI; PGRN; proepithelin; Progranulin
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国