产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD45R (B220) Monoclonal Antibody (RA3-6B2), eFluor™ 570, eBioscience
目录 :
41-0452-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
eFluor 570
克隆名称 :
RA3-6B2
反应物种 :
人类, 小鼠
应用 :
免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 41
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类
  • 免疫组化; 人类
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  • 免疫组化; 小鼠; 图 4i
Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, et al. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017;214:1129-1151 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 4
Kishimoto M, Matsuda T, Yanase S, Katsumi A, Suzuki N, Ikejiri M, et al. Rhof promotes murine marginal zone B cell development. Nagoya J Med Sci. 2014;76:293-305 pubmed
  • 免疫组化; 小鼠; 1:200; 图 7
Matsuda T, Yanase S, Takaoka A, Maruyama M. The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immun Ageing. 2015;12:1 pubmed 出版商
Guo L, Li N, Yang Z, Li H, Zheng H, Yang J, et al. Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection. Front Immunol. 2021;12:785457 pubmed 出版商
Wilfahrt D, Philips R, Lama J, Kizerwetter M, Shapiro M, McCue S, et al. Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation. elife. 2021;10: pubmed 出版商
Jeanne A, Sarazin T, Charlé M, Moali C, Fichel C, Boulagnon Rombi C, et al. Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity. Cancers (Basel). 2021;13: pubmed 出版商
Belliere J, Casemayou A, Colliou E, El Hachem H, Kounde C, Piedrafita A, et al. Ibrutinib does not prevent kidney fibrosis following acute and chronic injury. Sci Rep. 2021;11:11985 pubmed 出版商
Zaccagnini G, Greco S, Longo M, Maimone B, Voellenkle C, Fuschi P, et al. Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia. Cell Death Dis. 2021;12:435 pubmed 出版商
Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, et al. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation. Dis Model Mech. 2021;14: pubmed 出版商
Gaurav R, Mikuls T, Thiele G, Nelson A, Niu M, Guda C, et al. High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis. PLoS ONE. 2021;16:e0240707 pubmed 出版商
Mendes A, Gigan J, Rodríguez Rodrígues C, Choteau S, Sanséau D, Barros D, et al. Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. Life Sci Alliance. 2021;4: pubmed 出版商
Richmond B, Mansouri S, Serezani A, Novitskiy S, Blackburn J, Du R, et al. Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD. Mucosal Immunol. 2021;14:431-442 pubmed 出版商
Heimesaat M, Mousavi S, Kl xf8 ve S, Genger C, Weschka D, Tamas A, et al. Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice. Pathogens. 2020;9: pubmed 出版商
Heimesaat M, Genger C, Klove S, Weschka D, Mousavi S, Bereswill S. The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis. Pathogens. 2020;9: pubmed 出版商
Merlo L, Bowers J, Stefanoni T, Getts R, Mandik Nayak L. B-Cell-Targeted 3DNA Nanotherapy Against Indoleamine 2,3-Dioxygenase 2 (IDO2) Ameliorates Autoimmune Arthritis in a Preclinical Model. Clin Pathol. 2020;13:2632010X20951812 pubmed 出版商
Kreimann K, Jang M, Rong S, Greite R, von Vietinghoff S, Schmitt R, et al. Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation. Front Immunol. 2020;11:1204 pubmed 出版商
Cao H, Duan R, Hu J. Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term CFTR Expression in Mouse Airways. Genes (Basel). 2020;11: pubmed 出版商
Kløve S, Genger C, Mousavi S, Weschka D, Bereswill S, Heimesaat M. Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota. Pathogens. 2020;9: pubmed 出版商
Natsume C, Aoki N, Aoyama T, Senda K, Matsui M, Ikegami A, et al. Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells. Int J Mol Sci. 2020;21: pubmed 出版商
Broderick L, Yost S, Li D, McGeough M, Booshehri L, Guaderrama M, et al. Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019;10:3644 pubmed 出版商
Castro Dopico T, Dennison T, Ferdinand J, Mathews R, FLEMING A, Clift D, et al. Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity. 2019;50:1099-1114.e10 pubmed 出版商
Escher U, Giladi E, Dunay I, Bereswill S, Gozes I, Heimesaat M. Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis. Eur J Microbiol Immunol (Bp). 2018;8:34-40 pubmed 出版商
von Klitzing E, Ekmekciu I, Kühl A, Bereswill S, Heimesaat M. Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis. Sci Rep. 2018;8:6685 pubmed 出版商
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Dabydeen S, Kang K, Díaz Cruz E, Alamri A, Axelrod M, Bouker K, et al. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis. 2015;36:122-32 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD45R (B220) Monoclonal Antibody (RA3-6B2), eFluor™ 570, eBioscience
目录# :
41-0452-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 2 µg/mL
物种 :
人类, 小鼠
克隆 :
RA3-6B2
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-Dependent, Immunohistochemistry (Frozen): 1 µg/mL, Immunohistochemistry (Paraffin): 2 µg/mL
别名 :
B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国