产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雄激素受体单克隆抗体(H7507)
目录 :
415900
规格 :
100微升
价格 :
美国530.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
H7507
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 1
产品信息
产品类型 :
抗体
产品名称 :
雄激素受体单克隆抗体(H7507)
目录# :
415900
规格 :
100微升
价格 :
美国530.00
克隆性 :
单克隆
纯度 :
硫酸铵沉淀
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.3 µg/mL, Immunohistochemistry (Paraffin): 3-20 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
H7507
抗体亚型 :
IgG2a
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
免疫原 :
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human AR (2-53 aa).
格式 :
液体
应用w/稀释 :
ELISA: 0.3 µg/mL, Immunohistochemistry (Paraffin): 3-20 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
别名 :
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
更多信息或购买 :
公司信息
赛默飞世尔