产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
FXR单克隆抗体(A9033A)
目录 :
417200
规格 :
100微升
价格 :
美国556.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
A9033A
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 7
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 小鼠; 图 s1
Ijssennagger N, van Rooijen K, Magnúsdóttir S, Ramos Pittol J, Willemsen E, de Zoete M, et al. Ablation of liver Fxr results in an increased colonic mucus barrier in mice. JHEP Rep. 2021;3:100344 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
Sawitza I, Kordes C, Götze S, Herebian D, Häussinger D. Bile acids induce hepatic differentiation of mesenchymal stem cells. Sci Rep. 2015;5:13320 pubmed 出版商
Wang S, Sheng F, Zou L, Xiao J, Li P. Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism. J Adv Res. 2021;34:109-122 pubmed 出版商
Q Bartlett A, Vesco K, Purnell J, Francisco M, Goddard E, Guan X, et al. Pregnancy and weaning regulate human maternal liver size and function. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
Czarnecka A, Milewski K, Albrecht J, Zielinska M. The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure. Int J Mol Sci. 2020;21: pubmed 出版商
Ramos Pittol J, Milona A, Morris I, Willemsen E, van der Veen S, Kalkhoven E, et al. FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs. Gastroenterology. 2020;159:1853-1865.e10 pubmed 出版商
Li H, Xi Y, Xin X, Tian H, Hu Y. Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis. Nutr Metab (Lond). 2020;17:34 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
FXR单克隆抗体(A9033A)
目录# :
417200
规格 :
100微升
价格 :
美国556.00
克隆性 :
单克隆
纯度 :
硫酸铵沉淀
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.2 µg/mL, Immunohistochemistry (Frozen): 20-40 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
A9033A
抗体亚型 :
IgG2a
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
FXR (farnesoid X receptor; NR1H4) belongs to nuclear receptor superfamily of ligand-activated transcription factors (NR1 subfamily) and acts as a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. FXR plays an essential role in bile acid homeostasis through the regulation of genes involved in bile acid synthesis, conjugation and enterohepatic circulation. FXR also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. In the liver FXR activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs). FXR activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine). (From Uniprot)
免疫原 :
Baculovirus-expressed recombinant human FXR (2-126 aa).
格式 :
液体
应用w/稀释 :
ELISA: 0.2 µg/mL, Immunohistochemistry (Frozen): 20-40 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1 µg/mL
别名 :
AI957360; BAR; bile acid receptor; farnesoid X activated receptor; farnesoid X nuclear receptor; farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; HRR1; HRR-1; hypothetical protein LOC540528; MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; retinoid X receptor-interacting protein 14; RIP14; RXR-interacting protein 14; Rxrip14
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国