产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(101)
目录 :
436000
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
101
反应物种 :
人类, 小鼠, 大鼠, 非洲爪蛙, domestic rabbit, 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 13
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 非洲爪蛙; 图 1
Wiechmann A, Ceresa B, Howard E. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS ONE. 2014;9:e113810 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Morani A, Barros R, Imamov O, Hultenby K, Arner A, Warner M, et al. Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A. 2006;103:7165-9 pubmed
Tossetta G, Fantone S, Gesuita R, Goteri G, Senzacqua M, Marcheggiani F, et al. Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness. Cancers (Basel). 2022;14: pubmed 出版商
Shen X, Li L, He Y, Lv X, Ma J. EIF5A2 Is Involved in the Biological Process of Cervical Cancer Cells through AGR2. Pharmacology. 2022;107:376-385 pubmed 出版商
Nigro E, Mallardo M, Polito R, Scial xf2 F, Bianco A, Daniele A. Adiponectin and Leptin Exert Antagonizing Effects on HUVEC Tube Formation and Migration Modulating the Expression of CXCL1, VEGF, MMP-2 and MMP-9. Int J Mol Sci. 2021;22: pubmed 出版商
Morales Vasquez F, Castillo Sanchez R, Gómora M, Almaraz M, Pedernera E, Perez Montiel D, et al. Expression of metalloproteinases MMP-2 and MMP-9 is associated to the presence of androgen receptor in epithelial ovarian tumors. J Ovarian Res. 2020;13:86 pubmed 出版商
Bhurke A, Kannan A, Neff A, Ma Q, Laws M, Taylor R, et al. A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules. Proc Natl Acad Sci U S A. 2020;117:14532-14542 pubmed 出版商
Łanocha Arendarczyk N, Baranowska Bosiacka I, Gutowska I, Kolasa Wołosiuk A, Kot K, Łanocha A, et al. The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis. Int J Mol Sci. 2018;19: pubmed 出版商
Fouad H, Salem H, Ellakwa D, Abdel Hamid M. MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer. J Biochem Mol Toxicol. 2019;33:e22275 pubmed 出版商
Platen C, Dreschers S, Reiss L, Wappler J, Orlikowsky T. Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases. Mediators Inflamm. 2018;2018:4310419 pubmed 出版商
Qian Y, Song J, Sun P, Yi R, Liu H, Feng X, et al. Lactobacillus casei Strain Shirota Enhances the In Vitro Antiproliferative Effect of Geniposide in Human Oral Squamous Carcinoma HSC-3 Cells. Molecules. 2018;23: pubmed 出版商
Zandvakili I, Lin Y, Morris J, Zheng Y. Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene. 2017;36:3213-3222 pubmed 出版商
Ghorai A, Sarma A, Chowdhury P, Ghosh U. PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells. Radiat Oncol. 2016;11:126 pubmed
产品信息
产品类型 :
抗体
产品名称 :
MMP2单克隆抗体(101)
目录# :
436000
规格 :
100微克
价格 :
美国450.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rabbit, Rat, Rhesus Monkey
应用 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL
物种 :
Human, Mouse, Non-human primate, Rabbit, Rat, Rhesus Monkey
克隆 :
101
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
免疫原 :
Recombinant protein derived from the N-terminus of human MMP-2 protein (accession # P08253, NP_004521 ), which is identical to Rhesus monkey and chimpanzee and 98% similar to rat and rabbit and 97% to mouse.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 2 µg/mL
别名 :
72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
更多信息或购买 :
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公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国