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抗体

磷酸化粘着斑蛋白(Tyr1065)多克隆抗体

44-1078G

100微升

美国399.00

多克隆

domestic rabbit

未共轭

磷酸化

人类, 鸡

免疫印迹, 免疫细胞化学

磷酸化粘着斑蛋白(Tyr1065)多克隆抗体

44-1078G

100微升

美国399.00

多克隆

抗原亲和色谱

兔

鸡, 人类

Immunocytochemistry: 1:250, Western Blot: 1:1,000

鸡, 人类

IgG

-20°C

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.

The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human vinculin that contains tyrosine 1065. The sequence is conserved in mouse and chicken.

液体

Immunocytochemistry: 1:250, Western Blot: 1:1,000

9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; epididymis luminal protein 114; HEL114; metavinculin; meta-vinculin; metavinculin {ECO:0000250; MV; MVCL; RP11-178G16.3; UniProtKB:P18206}; unnamed protein product; Vcl; vcl {ECO:0000250; VIN; vinc; vinc 1; VINC1; Vinculin; vinculin {ECO:0000250