产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化SMAD家族成员2(Ser465, Ser467)多克隆抗体
目录 :
44-244G
规格 :
100微升
价格 :
美国500
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 26
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 1b
Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro García L, Nagarajah J, Saqcena M, et al. Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers. Endocr Relat Cancer. 2021;28:391-402 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:150; 图 6g
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed 出版商
  • 免疫细胞化学; 人类; 图 4a
Ruiz Gutierrez M, Bölükbaşı Ö, Alexe G, Kotini A, Ballotti K, Joyce C, et al. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 2019;5: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 s5d
Boutin A, Liao W, Wang M, Hwang S, Karpinets T, Cheung H, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017;31:370-382 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Kocsis T, Trencsenyi G, Szabó K, Baán J, Müller G, Mendler L, et al. Myostatin propeptide mutation of the hypermuscular Compact mice decreases the formation of myostatin and improves insulin sensitivity. Am J Physiol Endocrinol Metab. 2017;312:E150-E160 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 2d
Liang Y, Zhu F, Zhang H, Chen D, Zhang X, Gao Q, et al. Conditional ablation of TGF-? signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model. Sci Rep. 2016;6:29479 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Margaryan N, Gilgur A, Seftor E, Purnell C, Arva N, Gosain A, et al. Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi. Int J Mol Sci. 2016;17:418 pubmed 出版商
Fang C, Chen S, Huang C, Liao Y, Chao S, Yu C. Fucoidan-Mediated Inhibition of Fibrotic Properties in Oral Submucous Fibrosis via the MEG3/miR-181a/Egr1 Axis. Pharmaceuticals (Basel). 2022;15: pubmed 出版商
Song I, Nagamani S, Nguyen D, Grafe I, Sutton V, Gannon F, et al. Targeting TGF-β for treatment of osteogenesis imperfecta. J Clin Invest. 2022;132: pubmed 出版商
Deng R, Li C, Wang X, Chang L, Ni S, Zhang W, et al. Periosteal CD68+ F4/80+ Macrophages Are Mechanosensitive for Cortical Bone Formation by Secretion and Activation of TGF-β1. Adv Sci (Weinh). 2022;9:e2103343 pubmed 出版商
Schilpp C, Lochbaum R, Braubach P, Jonigk D, Frick M, Dietl P, et al. TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei. Pflugers Arch. 2021;473:287-311 pubmed 出版商
Yoon J, Lee H, Kim H, Han B, Lee H, Lee Y, et al. Sauchinone Protects Renal Mesangial Cell Dysfunction against Angiotensin II by Improving Renal Fibrosis and Inflammation. Int J Mol Sci. 2020;21: pubmed 出版商
Gabitova Cornell L, Surumbayeva A, Peri S, Franco Barraza J, Restifo D, Weitz N, et al. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020;38:567-583.e11 pubmed 出版商
Ghiroldi A, Piccoli M, Creo P, Cirillo F, Rota P, D Imperio S, et al. Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation. Biochem J. 2020;477:3401-3415 pubmed 出版商
Brkić J, Dunk C, Shan Y, O Brien J, Lye P, Qayyum S, et al. Differential Role of Smad2 and Smad3 in the Acquisition of an Endovascular Trophoblast-Like Phenotype and Preeclampsia. Front Endocrinol (Lausanne). 2020;11:436 pubmed 出版商
Watanabe H, Goto S, Kato R, Komiyama S, Nagaoka Y, Kazama T, et al. The neovascularization effect of dedifferentiated fat cells. Sci Rep. 2020;10:9211 pubmed 出版商
Wójcik Pszczoła K, Chłoń Rzepa G, Jankowska A, Ślusarczyk M, Ferdek P, Kusiak A, et al. A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling. Int J Mol Sci. 2020;21: pubmed 出版商
Chamberlin T, Thompson V, Hillers Ziemer L, Walton B, Arendt L. Obesity reduces mammary epithelial cell TGFβ1 activity through macrophage-mediated extracellular matrix remodeling. FASEB J. 2020;34:8611-8624 pubmed 出版商
Sami E, Paul B, Koziol J, ElShamy W. The Immunosuppressive Microenvironment in BRCA1-IRIS-Overexpressing TNBC Tumors Is Induced by Bidirectional Interaction with Tumor-Associated Macrophages. Cancer Res. 2020;80:1102-1117 pubmed 出版商
Omene C, Ma L, Moore J, Ouyang H, Illa Bochaca I, Chou W, et al. Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention. Cancer Immunol Res. 2020;8:217-229 pubmed 出版商
Wegner K, Mueller B, Unterberger C, Avila E, Ruetten H, Turco A, et al. Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. J Pathol. 2020;250:231-242 pubmed 出版商
Arif E, Solanki A, Srivastava P, Rahman B, Tash B, Holzman L, et al. The motor protein Myo1c regulates transforming growth factor-β-signaling and fibrosis in podocytes. Kidney Int. 2019;96:139-158 pubmed 出版商
Carnevale D, Facchinello N, Iodice D, Bizzotto D, Perrotta M, De Stefani D, et al. Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans. Arterioscler Thromb Vasc Biol. 2018;38:2484-2497 pubmed 出版商
Caja L, Tzavlaki K, Dadras M, Tan E, Hatem G, Maturi N, et al. Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells. Oncogene. 2018;37:2515-2531 pubmed 出版商
David J, Dominguez C, McCampbell K, Gulley J, Schlom J, Palena C. A novel bifunctional anti-PD-L1/TGF-? Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells. Oncoimmunology. 2017;6:e1349589 pubmed 出版商
Strizzi L, Sandomenico A, Margaryan N, Focà A, Sanguigno L, Bodenstine T, et al. Effects of a novel Nodal-targeting monoclonal antibody in melanoma. Oncotarget. 2015;6:34071-86 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化SMAD家族成员2(Ser465, Ser467)多克隆抗体
目录# :
44-244G
规格 :
100微升
价格 :
美国500
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
ChIP assay: 10 µL, Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1000
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. SMAD2 can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the SMAD2 protein have been observed.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human Smad2 that contains serines 465 and 467. The sequence is conserved in mouse and rat.
格式 :
液体
应用w/稀释 :
ChIP assay: 10 µL, Immunocytochemistry: 1:250, Immunofluorescence: 1:250, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1000
别名 :
7120426M23Rik; EGK_09664; hMAD-2; hSMAD2; JV18; JV18-1; MAD; MAD homolog 2; Mad protein homolog; Madh2; MADR2; mad-related protein 2; MGC22139; MGC34440; mMad2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic-like protein 2; mothers against DPP homolog 2; pSMAD2; Sma- and Mad-related protein 2; SMAD; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Smad2; Smad-2; Smad2Deltaexon3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国