产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化PYK2(Tyr402)多克隆抗体
目录 :
44-618G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, 鸡
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:500; 图 1c
Gao C, Chen G, Zhang D, Zhang J, Kuan S, Hu W, et al. PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654. Cell Mol Gastroenterol Hepatol. 2019;8:561-578 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3c
Grossi M, Bhattachariya A, Nordström I, Turczynska K, Svensson D, Albinsson S, et al. Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle. J Cell Physiol. 2017;232:3088-3102 pubmed 出版商
Ko S, Jung K, Yoon Y, Han B, Park M, Lee Y, et al. A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer. Am J Cancer Res. 2022;12:4326-4342 pubmed
Momin A, Mendes T, Barthe P, Faure C, Hong S, Yu P, et al. PYK2 senses calcium through a disordered dimerization and calmodulin-binding element. Commun Biol. 2022;5:800 pubmed 出版商
Afonso P, De Luca P, Carvalho R, Cortes L, Pinheiro P, Oliveiros B, et al. BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons. Sci Signal. 2019;12: pubmed 出版商
Hirschler Laszkiewicz I, Chen S, Bao L, Wang J, Zhang X, Shanmughapriya S, et al. The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Am J Physiol Cell Physiol. 2018;315:C571-C586 pubmed 出版商
Roselova P, Obr A, Holoubek A, Grebenová D, Kuzelova K. Adhesion structures in leukemia cells and their regulation by Src family kinases. Cell Adh Migr. 2018;12:286-298 pubmed 出版商
Wang W, Jia Y, Pham D, Palmer L, Jung K, Cox C, et al. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cereb Cortex. 2018;28:2253-2266 pubmed 出版商
Giralt A, Coura R, Girault J. Pyk2 is essential for astrocytes mobility following brain lesion. Glia. 2016;64:620-34 pubmed 出版商
Mills R, Mita M, Nakagawa J, Shoji M, Sutherland C, Walsh M. A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle. J Biol Chem. 2015;290:8677-92 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化PYK2(Tyr402)多克隆抗体
目录# :
44-618G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
鸡, 人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000
物种 :
鸡, 人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosine 402. The sequence is conserved in rat.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1:1,000
别名 :
CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国