产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化AKT1(Ser473)单克隆抗体(14-6)
目录 :
44-621G
规格 :
100微升
价格 :
美国500.00
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
14-6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 63
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 6d
Sun Y, Jing J, Xu H, Xu L, Hu H, Tang C, et al. N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells. J Immunother Cancer. 2021;9: pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Matte I, Garde Granger P, Bessette P, Piche A. Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway. BMC Cancer. 2019;19:406 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3a
He P, Yang J, Yang V, Bialkowska A. Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. Gastroenterology. 2018;154:1494-1508.e13 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2c
Chamma C, Bargut T, Mandarim de Lacerda C, Aguila M. A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation. Food Funct. 2017;8:778-787 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5d
Martins F, Bargut T, Aguila M, Mandarim de Lacerda C. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann Anat. 2017;210:44-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4g
Graus Nunes F, Marinho T, Barbosa da Silva S, Aguila M, Mandarim de Lacerda C, Souza Mello V. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Mol Cell Endocrinol. 2017;439:54-64 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2500; 图 6
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  • 免疫印迹; 人类; 1:1000; 图 3
Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, et al. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS ONE. 2016;11:e0152538 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Borges C, Salles A, Bringhenti I, Souza Mello V, Mandarim de Lacerda C, Aguila M. Adverse effects of vitamin D deficiency on the Pi3k/Akt pathway and pancreatic islet morphology in diet-induced obese mice. Mol Nutr Food Res. 2016;60:346-57 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Rueda Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, et al. p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget. 2015;6:21240-54 pubmed
  • 免疫印迹; 小鼠
Bargut T, Mandarim de Lacerda C, Aguila M. A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. J Nutr Biochem. 2015;26:960-9 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Matte I, Lane D, Laplante C, Garde Granger P, Rancourt C, Piché A. Ovarian cancer ascites enhance the migration of patient-derived peritoneal mesothelial cells via cMet pathway through HGF-dependent and -independent mechanisms. Int J Cancer. 2015;137:289-98 pubmed 出版商
  • 免疫印迹; 人类
Beltran P, Calzone F, Mitchell P, Chung Y, Cajulis E, Moody G, et al. Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy. Clin Cancer Res. 2014;20:2947-58 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Diaz Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, et al. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013;6:ra105 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lee H, Schaefer G, Heffron T, Shao L, Ye X, Sideris S, et al. Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov. 2013;3:168-81 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Ruschmann J, Antignano F, Lam V, Snyder K, Kim C, Essak M, et al. The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells. J Immunol. 2012;188:3839-50 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4
Shohat M, Ben Meir D, Lavi S. Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in the differentiation and survival processes of nerve cells. PLoS ONE. 2012;7:e32438 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Wilson T, Lee D, Berry L, Shames D, Settleman J. Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell. 2011;20:158-72 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Cerezo A, Guadamillas M, Goetz J, Sánchez Perales S, Klein E, Assoian R, et al. The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism. Mol Cell Biol. 2009;29:5046-59 pubmed 出版商
Chen B, Zheng L, Zhu T, Jiao K. LncRNA FOXD3-AS1 aggravates myocardial ischemia/reperfusion injury by inactivating the Redd1/AKT/GSK3β/Nrf2 signaling pathway via the miR-128/TXNIP axis. J Biochem Mol Toxicol. 2022;36:e23218 pubmed 出版商
Cabral Dias R, Lucarelli S, Zak K, Rahmani S, Judge G, Abousawan J, et al. Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling. J Cell Biol. 2022;221: pubmed 出版商
Jang S, Jung B, An Y, Jang H. The phosphatase and tensin homolog gene inserted between NP and P gene of recombinant New castle disease virus oncolytic effect test to glioblastoma cell and xenograft mouse model. Virol J. 2022;19:21 pubmed 出版商
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Xiong S, Zhao Y, Xu T. DNA methyltransferase 3 beta mediates the methylation of the microRNA-34a promoter and enhances chondrocyte viability in osteoarthritis. Bioengineered. 2021;12:11138-11155 pubmed 出版商
Ren S, Tan X, Fu M, Ren S, Wu X, Chen T, et al. Downregulation of miR-375 contributes to ERBB2-mediated VEGFA overexpression in esophageal cancer. J Cancer. 2021;12:7138-7146 pubmed 出版商
Li S, Qin C, Chen Y, Wei D, Tan Z, Meng J. Implications of cell division cycle associated 4 on the Wilm's tumor cells viability via AKT/mTOR signaling pathway. Ren Fail. 2021;43:1470-1478 pubmed 出版商
Li Q, Wang Y, He J. MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5. J Clin Lab Anal. 2021;35:e23853 pubmed 出版商
Wu Y, Huang Y, Zhang W, Gunst S. The proprotein convertase furin inhibits IL-13-induced inflammation in airway smooth muscle by regulating integrin-associated signaling complexes. Am J Physiol Lung Cell Mol Physiol. 2021;321:L102-L115 pubmed 出版商
Montt Guevara M, Finiguerra M, Marzi I, Fidecicchi T, Ferrari A, Genazzani A, et al. D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes. Front Endocrinol (Lausanne). 2021;12:660815 pubmed 出版商
Alzahrani A, Rajendran P, Veeraraghavan V, Hanieh H. Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways. Int J Mol Sci. 2021;22: pubmed 出版商
Kopietz F, Alshuweishi Y, Bijland S, Alghamdi F, Degerman E, Sakamoto K, et al. A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. Biochem J. 2021;478:633-646 pubmed 出版商
Paul R, Whiteman K, Falconer S, Oldham J, Jeanplong F, Matthews K, et al. IGF1 does not overcome sexual dimorphism of body and muscle size in Mstn-/- mice. J Endocrinol. 2021;248:207-220 pubmed 出版商
Pucci S, Fasoli F, Moretti M, Benfante R, Di Lascio S, Viani P, et al. Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. Pharmacol Res. 2021;163:105336 pubmed 出版商
Baltazar Lara R, Ávila Mendoza J, Martínez Moreno C, Carranza M, Pech Pool S, Vázquez Martínez O, et al. Neuroprotective Effects of Growth Hormone (GH) and Insulin-Like Growth Factor Type 1 (IGF-1) after Hypoxic-Ischemic Injury in Chicken Cerebellar Cell Cultures. Int J Mol Sci. 2020;22: pubmed 出版商
Rajendran P, Ammar R, Al Saeedi F, Mohamed M, ElNaggar M, Al ramadan S, et al. Kaempferol Inhibits Zearalenone-Induced Oxidative Stress and Apoptosis via the PI3K/Akt-Mediated Nrf2 Signaling Pathway: In Vitro and In Vivo Studies. Int J Mol Sci. 2020;22: pubmed 出版商
Liu B, Sun W, Gao W, Li L, Cao Z, Yang X, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019 pubmed 出版商
Kopietz F, Rupar K, Berggreen C, S xe4 ll J, Vertommen D, Degerman E, et al. Inhibition of AMPK activity in response to insulin in adipocytes: involvement of AMPK pS485, PDEs, and cellular energy levels. Am J Physiol Endocrinol Metab. 2020;319:E459-E471 pubmed 出版商
Huang Y, Gunst S. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt. Am J Physiol Lung Cell Mol Physiol. 2020;318:L1036-L1055 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化AKT1(Ser473)单克隆抗体(14-6)
目录# :
44-621G
规格 :
100微升
价格 :
美国500.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000
物种 :
人类, 小鼠
克隆 :
14-6
抗体亚型 :
IgG
储存 :
-20°C
描述 :
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
免疫原 :
The antibody was produced against a chemically synthesized phosphopeptide derived from the region of human Akt that contains serine 473.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000
别名 :
Akt; Akt kinase; AKT serine/threonine kinase 1; Akt/PKB; akt1; AKT1 kinase; AKT1m; Akt1m protein; Akt1-PA; Akt1-PB; Akt1-PC; Akt1-PD; Akt1-PE; CAKT; C-AKT; CG4006; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; CWS6; dAkt; D-Akt; dAkt kinase; dAKT/dPKB; dAkt/PKB; DAKT1; DAKT1/PKB; Dmel CG4006; Dmel_CG4006; dPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; murine thymoma viral (v-akt) oncogene homolog 1; pAkt; P-AKT; PKB; PKB alpha; PKB beta; PKB gamma; PKB/AKT; PKB/dAKT; PKBalpha; PKB-ALPHA; PKBG; PRKBA; protein kinase B; Protein kinase B alpha; protein kinase B-alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC serine/threonine protein kinase; RAC serine/threonine-protein kinase; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RacPK; RAC-PK-alpha; RAC-PK-beta; RAC-PK-gamma; related to A and C kinases; related to PKA to PKC protein kinases; related to the A and C kinases; SD10374p; serine/threonine protein kinase; serine-threonine protein kinase; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国