产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化AKT1(Ser473)单克隆抗体(14-6)
目录 :
44-621G
规格 :
100微升
价格 :
425美元
克隆性 :
单克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
14-6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 5b
Matte I, Garde Granger P, Bessette P, Piche A. Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway. BMC Cancer. 2019;19:406 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s3a
He P, Yang J, Yang V, Bialkowska A. Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. Gastroenterology. 2018;154:1494-1508.e13 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2c
Chamma C, Bargut T, Mandarim de Lacerda C, Aguila M. A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation. Food Funct. 2017;8:778-787 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5d
Martins F, Bargut T, Aguila M, Mandarim de Lacerda C. Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann Anat. 2017;210:44-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 4g
Graus Nunes F, Marinho T, Barbosa da Silva S, Aguila M, Mandarim de Lacerda C, Souza Mello V. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Mol Cell Endocrinol. 2017;439:54-64 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2500; 图 6
Puchert M, Adams V, Linke A, Engele J. Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise. Cell Signal. 2016;28:1205-15 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, et al. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS ONE. 2016;11:e0152538 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Borges C, Salles A, Bringhenti I, Souza Mello V, Mandarim de Lacerda C, Aguila M. Adverse effects of vitamin D deficiency on the Pi3k/Akt pathway and pancreatic islet morphology in diet-induced obese mice. Mol Nutr Food Res. 2016;60:346-57 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Rueda Rincon N, Bloch K, Derua R, Vyas R, Harms A, Hankemeier T, et al. p53 attenuates AKT signaling by modulating membrane phospholipid composition. Oncotarget. 2015;6:21240-54 pubmed
  • 免疫印迹; 小鼠
Bargut T, Mandarim de Lacerda C, Aguila M. A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. J Nutr Biochem. 2015;26:960-9 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Matte I, Lane D, Laplante C, Garde Granger P, Rancourt C, Piché A. Ovarian cancer ascites enhance the migration of patient-derived peritoneal mesothelial cells via cMet pathway through HGF-dependent and -independent mechanisms. Int J Cancer. 2015;137:289-98 pubmed 出版商
  • 免疫印迹; 人类
Beltran P, Calzone F, Mitchell P, Chung Y, Cajulis E, Moody G, et al. Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy. Clin Cancer Res. 2014;20:2947-58 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Diaz Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, et al. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013;6:ra105 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lee H, Schaefer G, Heffron T, Shao L, Ye X, Sideris S, et al. Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov. 2013;3:168-81 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Poovassery J, Bishop G. Type I IFN receptor and the B cell antigen receptor regulate TLR7 responses via distinct molecular mechanisms. J Immunol. 2012;189:1757-64 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Ruschmann J, Antignano F, Lam V, Snyder K, Kim C, Essak M, et al. The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells. J Immunol. 2012;188:3839-50 pubmed 出版商
  • 免疫印迹; 大鼠; 图 4
Shohat M, Ben Meir D, Lavi S. Protein phosphatase magnesium dependent 1A (PPM1A) plays a role in the differentiation and survival processes of nerve cells. PLoS ONE. 2012;7:e32438 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Wilson T, Lee D, Berry L, Shames D, Settleman J. Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell. 2011;20:158-72 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Cerezo A, Guadamillas M, Goetz J, Sánchez Perales S, Klein E, Assoian R, et al. The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism. Mol Cell Biol. 2009;29:5046-59 pubmed 出版商
Liu B, Sun W, Gao W, Li L, Cao Z, Yang X, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019 pubmed 出版商
Chalenko Y, Kalinin E, Marchenkov V, Sysolyatina E, Surin A, Sobyanin K, et al. Phylogenetically Defined Isoforms of Listeria monocytogenes Invasion Factor InlB Differently Activate Intracellular Signaling Pathways and Interact with the Receptor gC1q-R. Int J Mol Sci. 2019;20: pubmed 出版商
Sferra R, Pompili S, Ventura L, Dubuquoy C, Speca S, Gaudio E, et al. Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study. Eur J Histochem. 2018;62: pubmed 出版商
Hansen J, de Marè S, Jones H, Göransson O, Lindkvist Petersson K. Visualization of lipid directed dynamics of perilipin 1 in human primary adipocytes. Sci Rep. 2017;7:15011 pubmed 出版商
Eritano A, Altamirano A, Beyeler S, Gaytan N, Velasquez M, Riggs B. The endoplasmic reticulum is partitioned asymmetrically during mitosis before cell fate selection in proneuronal cells in the early Drosophila embryo. Mol Biol Cell. 2017;28:1530-1538 pubmed 出版商
Sackstein R, Schatton T, Barthel S. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017;97:669-697 pubmed 出版商
Chen W, Tang X, Yang X, Weng C, Yang K, Wen J, et al. Effects and Mechanisms of Radiofrequency Ablation of Renal Sympathetic Nerve on Anti-Hypertension in Canine. Arq Bras Cardiol. 2017;108:237-245 pubmed 出版商
Kumari P, Srivastava A, Ghosh E, Ranjan R, Dogra S, Yadav P, et al. Core engagement with ?-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation. Mol Biol Cell. 2017;28:1003-1010 pubmed 出版商
Hatakeyama H, Nakahata Y, Yarimizu H, Kanzaki M. Live-cell single-molecule labeling and analysis of myosin motors with quantum dots. Mol Biol Cell. 2017;28:173-181 pubmed 出版商
Zandvakili I, Lin Y, Morris J, Zheng Y. Rho GTPases: Anti- or pro-neoplastic targets?. Oncogene. 2017;36:3213-3222 pubmed 出版商
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Ai J, Pascal L, Wei L, Zang Y, Zhou Y, Yu X, et al. EAF2 regulates DNA repair through Ku70/Ku80 in the prostate. Oncogene. 2017;36:2054-2065 pubmed 出版商
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, et al. An in vitro model of murine middle ear epithelium. Dis Model Mech. 2016;9:1405-1417 pubmed
Maksimov V, Wäneskog M, Rodriguez A, Bjerling P. Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans. Curr Genet. 2017;63:343-357 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化AKT1(Ser473)单克隆抗体(14-6)
目录# :
44-621G
规格 :
100微升
价格 :
425美元
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1000
物种 :
人类, 小鼠
克隆 :
14-6
抗体亚型 :
IgG
储存 :
-20°C
描述 :
AKT also known as protein kinase B (PKB) or RAS-alpha, is an ubiquitous serine/threonine kinase that plays an important role in diverse biological responses such as regulation of metabolism, cell survival and growth by phosphorylating multiple proteins. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
免疫原 :
The antibody was produced against a chemically synthesized phosphopeptide derived from the region of human Akt that contains serine 473.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1000
别名 :
Akt; Akt kinase; AKT serine/threonine kinase 1; AKT/PKB; AKT1; AKT1 kinase; AKT1m; Akt1m protein; Akt1-PA; Akt1-PB; Akt1-PC; Akt1-PD; Akt1-PE; CAKT; C-AKT; CG4006; CG4006 gene product from transcript CG4006-RE; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; CWS6; dakt; D-Akt; dAkt kinase; dAKT/dPKB; dAkt/PKB; DAKT1; DAKT1/PKB; Dmel CG4006; Dmel_CG4006; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; murine thymoma viral (v-akt) oncogene homolog 1; pAkt; p-Akt; PKB; PKB alpha; PKB beta; PKB gamma; PKB/AKT; PKB/dAKT; PKBalpha; PKB-ALPHA; PKBG; PRKBA; Protein kinase B; protein kinase B alpha; protein kinase B-alpha; proto-oncogene c-Akt; Rac; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC serine/threonine-protein kinase; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RacPK; RAC-PK-alpha; RAC-PK-beta; RAC-PK-gamma; related to A and C kinases; related to PKA to PKC protein kinases; related to the A and C kinases; serine/threonine protein kinase; serine-threonine protein kinase; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国