产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化FAK(Tyr861)多克隆抗体
目录 :
44-626G
规格 :
100微升
价格 :
美国375.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 鸡, 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 26
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 6d
Reed M, Luissint A, Azcutia V, Fan S, O Leary M, Quirós M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019;10:5004 pubmed 出版商
  • 免疫细胞化学; 人类; 图 8f
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3c
Benito Jardón M, Klapproth S, Gimeno LLuch I, Petzold T, Bharadwaj M, Müller D, et al. The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. elife. 2017;6: pubmed 出版商
  • 免疫组化; 鸡; 1:200; 图 7a
McKinney M, McLennan R, Kulesa P. Angiopoietin 2 signaling plays a critical role in neural crest cell migration. BMC Biol. 2016;14:111 pubmed
  • 免疫组化; 小鼠; 图 6a
  • 免疫印迹; 小鼠; 图 6e
Peng D, Ungewiss C, Tong P, Byers L, Wang J, Canales J, et al. ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. Oncogene. 2017;36:1925-1938 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Adam A, Lowery A, Martino N, Alsaffar H, Vincent P. Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling. PLoS ONE. 2016;11:e0161975 pubmed 出版商
  • 免疫细胞化学; 斑马鱼; 表 4
Venero Galanternik M, Navajas Acedo J, Romero Carvajal A, Piotrowski T. Imaging collective cell migration and hair cell regeneration in the sensory lateral line. Methods Cell Biol. 2016;134:211-56 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50
  • 免疫印迹; 小鼠; 图 5
Ungewiss C, Rizvi Z, Roybal J, Peng D, Gold K, Shin D, et al. The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL. Sci Rep. 2016;6:18652 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 表 1
Oudart J, Doué M, Vautrin A, Brassart B, Sellier C, Dupont Deshorgue A, et al. The anti-tumor NC1 domain of collagen XIX inhibits the FAK/ PI3K/Akt/mTOR signaling pathway through αvβ3 integrin interaction. Oncotarget. 2016;7:1516-28 pubmed 出版商
Rose M, Espinoza V, Hoff K, Pike L, Sharma V, Hofmann M, et al. BCL2L11 Induction Mediates Sensitivity to Src and MEK1/2 Inhibition in Thyroid Cancer. Cancers (Basel). 2023;15: pubmed 出版商
Mahabaleshwar H, AshaRani P, Loo T, Koh S, Pitman M, Kwok S, et al. Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme. EMBO Rep. 2022;23:e54464 pubmed 出版商
Steenkiste E, Berndt J, Pilling C, Simpkins C, Cooper J. A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics. elife. 2021;10: pubmed 出版商
Lees D, Reynolds L, Pedrosa A, Roy Luzarraga M, Hodivala Dilke K. Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression. Angiogenesis. 2021;24:471-482 pubmed 出版商
Yoon J, Wang J, Roehrl M. A combined FAK, c-MET, and MST1R three-protein panel risk-stratifies colorectal cancer patients. Transl Oncol. 2020;13:100836 pubmed 出版商
Goldstein L, Perez R, Yardley D, Han L, Reuben J, Gao H, et al. A window-of-opportunity trial of the CXCR1/2 inhibitor reparixin in operable HER-2-negative breast cancer. Breast Cancer Res. 2020;22:4 pubmed 出版商
McLennan R, McKinney M, Teddy J, Morrison J, Kasemeier Kulesa J, Ridenour D, et al. Neural crest cells bulldoze through the microenvironment using Aquaporin 1 to stabilize filopodia. Development. 2020;147: pubmed 出版商
Hermida Prado F, Villaronga M, Granda Díaz R, Del Río Ibisate N, Santos L, Hermosilla M, et al. The SRC Inhibitor Dasatinib Induces Stem Cell-Like Properties in Head and Neck Cancer Cells that are Effectively Counteracted by the Mithralog EC-8042. J Clin Med. 2019;8: pubmed 出版商
Wang B, Pan J, Yu H, Xiong L, Zhao K, Xiong S, et al. Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells. J Bone Miner Res. 2019;34:939-954 pubmed 出版商
Kessler B, Mishall K, Kellett M, Clark E, Pugazhenthi U, Pozdeyev N, et al. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. 2019;38:2565-2579 pubmed 出版商
Hughes V, Siemann D. Treatment with Src inhibitor Dasatinib results in elevated metastatic potential in the 4T1 murine mammary carcinoma model. Tumor Microenviron. 2018;1:30-36 pubmed 出版商
Miskolczi Z, Smith M, Rowling E, Ferguson J, Barriuso J, Wellbrock C. Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing. Oncogene. 2018;37:3166-3182 pubmed 出版商
Beadnell T, Nassar K, Rose M, Clark E, Danysh B, Hofmann M, et al. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018;7:23 pubmed 出版商
Mishall K, Beadnell T, Kuenzi B, Klimczak D, Superti Furga G, Rix U, et al. Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer. Oncotarget. 2017;8:103014-103031 pubmed 出版商
Moen I, Gebre M, Alonso Camino V, Chen D, Epstein D, McDonald D. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015;32:799-817 pubmed 出版商
Vecino E, Heller J, Veiga Crespo P, Martin K, Fawcett J. Influence of extracellular matrix components on the expression of integrins and regeneration of adult retinal ganglion cells. PLoS ONE. 2015;10:e0125250 pubmed 出版商
Rios Doria J, Sabol D, Chesebrough J, Stewart D, Xu L, Tammali R, et al. A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways. Mol Cancer Ther. 2015;14:1637-49 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化FAK(Tyr861)多克隆抗体
目录# :
44-626G
规格 :
100微升
价格 :
美国375.00
克隆性 :
多克隆
纯度 :
亲和色谱
宿主 :
兔
反应物种 :
鸡, 人类, 小鼠
应用 :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
物种 :
鸡, 人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human FAK that contains tyrosine 861. The sequence is conserved in mouse, rat, chicken and frog.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:250, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
别名 :
CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国