产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化ERK1/ERK2(Thr185, Tyr187)多克隆抗体
目录 :
44-680G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, 鸡, 牛, fruit fly , 非洲爪蛙, roundworm
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 40
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1d
Roversi F, Pericole F, Machado Neto J, da Silva Santos Duarte A, Longhini A, Corrocher F, et al. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway. Biochim Biophys Acta Mol Basis Dis. 2017;1863:450-461 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Caporali S, Alvino E, Lacal P, Levati L, Giurato G, Memoli D, et al. Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor. Int J Oncol. 2016;49:1164-74 pubmed 出版商
  • 免疫印迹; 人类; 图 s3b
  • 免疫印迹; 小鼠; 图 5e
Köchl R, Thelen F, Vanes L, Brazão T, Fountain K, Xie J, et al. WNK1 kinase balances T cell adhesion versus migration in vivo. Nat Immunol. 2016;17:1075-83 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, et al. Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat Commun. 2016;7:11030 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Wang J, Goetsch L, Tucker L, Zhang Q, Gonzalez A, Vaidya K, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016;16:105 pubmed 出版商
  • 免疫印迹; 大鼠; 图 5
Fan S, Numata Y, Numata M. Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration. Mol Biol Cell. 2016;27:702-15 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Salas E, Roy S, Marsh T, Rubin B, Debnath J. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016;35:2913-22 pubmed 出版商
Ortiz D, Kim M, Lee H, Botanas C, Custodio R, Sayson L, et al. 4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism. Biomol Ther (Seoul). 2023;31:227-239 pubmed 出版商
Ming D, Ma J. EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways. Open Med (Wars). 2022;17:2098-2108 pubmed 出版商
Qi Y, Zou H, Zhao X, Kapeleris J, Monteiro M, Li F, et al. Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway. Front Pharmacol. 2022;13:996053 pubmed 出版商
Liu P, Wang J, Peng S, Zhang D, Zhuang L, Liu C, et al. Suppression of phosphodiesterase IV enzyme by roflumilast ameliorates cognitive dysfunction in aged rats after sevoflurane anaesthesia via PKA-CREB and MEK/ERK pathways. Eur J Neurosci. 2022;56:4317-4332 pubmed 出版商
Dou C, Zhen G, Dan Y, Wan M, Limjunyawong N, Cao X. Sialylation of TLR2 initiates osteoclast fusion. Bone Res. 2022;10:24 pubmed 出版商
Hern xe1 ndez Bule M, Mart xed nez M, Trillo M, Mart xed nez L, Toledano Mac xed as E, xda beda A. Response of human cancer cells to simultaneous treatment with sorafenib and radiofrequency current. Oncol Lett. 2021;22:807 pubmed 出版商
Roversi F, Bueno M, Pericole F, Saad S. Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk Between Hematopoietic Cells and Bone Marrow Niche Through CXCL12/CXCR4 Axis. Front Cell Dev Biol. 2021;9:634044 pubmed 出版商
Ruiz Heiland G, Yong J, von Bremen J, Ruf S. Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment. Clin Oral Investig. 2021;25:1933-1944 pubmed 出版商
Yong J, von Bremen J, Ruiz Heiland G, Ruf S. Adiponectin Interacts In-Vitro With Cementoblasts Influencing Cell Migration, Proliferation and Cementogenesis Partly Through the MAPK Signaling Pathway. Front Pharmacol. 2020;11:585346 pubmed 出版商
Guo C, Davies M, Hawkins C. Role of thiocyanate in the modulation of myeloperoxidase-derived oxidant induced damage to macrophages. Redox Biol. 2020;36:101666 pubmed 出版商
Abdel Latif G, Elwahab A, Hasan R, ElMongy N, Ramzy M, Louka M, et al. A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories. Sci Rep. 2020;10:13045 pubmed 出版商
Dong G, Huang X, Jiang S, Ni L, Chen S. Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells. Oxid Med Cell Longev. 2019;2019:6026051 pubmed 出版商
Xuan Z, Wang Y, Xie J. ANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway. Onco Targets Ther. 2019;12:6721-6731 pubmed 出版商
Hernández Bule M, Medel E, Colastra C, Roldan R, Ubeda A. Response of neuroblastoma cells to RF currents as a function of the signal frequency. BMC Cancer. 2019;19:889 pubmed 出版商
Dong G, Lin X, Liu H, Gao D, Cui J, Ren Z, et al. Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells. Oncol Lett. 2019;18:1831-1839 pubmed 出版商
Kleinschmidt E, Miller N, Ozmadenci D, Tancioni I, Osterman C, Barrie A, et al. Rgnef promotes ovarian tumor progression and confers protection from oxidative stress. Oncogene. 2019;38:6323-6337 pubmed 出版商
Castany S, Codony X, Zamanillo D, Merlos M, Verdú E, Boadas Vaello P. Repeated Sigma-1 Receptor Antagonist MR309 Administration Modulates Central Neuropathic Pain Development After Spinal Cord Injury in Mice. Front Pharmacol. 2019;10:222 pubmed 出版商
Martínez M, Ubeda A, Trillo M. Involvement of the EGF Receptor in MAPK Signaling Activation by a 50 Hz Magnetic Field in Human Neuroblastoma Cells. Cell Physiol Biochem. 2019;52:893-907 pubmed 出版商
Förster S, Koziol U, Schäfer T, Duvoisin R, Cailliau K, Vanderstraete M, et al. The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction. PLoS Negl Trop Dis. 2019;13:e0006959 pubmed 出版商
Bagati A, Moparthy S, Fink E, Bianchi Smiraglia A, Yun D, Kolesnikova M, et al. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019;38:3585-3597 pubmed 出版商
Walker S, Selfors L, Margolis B, Brugge J. CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin. PLoS ONE. 2018;13:e0207470 pubmed 出版商
Bilal S, Jaggi S, Janosevic D, Shah N, Teymour S, Voronina A, et al. ZO-1 protein is required for hydrogen peroxide to increase MDCK cell paracellular permeability in an ERK 1/2-dependent manner. Am J Physiol Cell Physiol. 2018;315:C422-C431 pubmed 出版商
Chen M, Hale C, Stanislaus S, Xu J, Véniant M. FGF21 acts as a negative regulator of bile acid synthesis. J Endocrinol. 2018;237:139-152 pubmed 出版商
Castany S, Gris G, Vela J, Verdú E, Boadas Vaello P. Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice. Sci Rep. 2018;8:3873 pubmed 出版商
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Martínez M, Ubeda A, Moreno J, Trillo M. Power Frequency Magnetic Fields Affect the p38 MAPK-Mediated Regulation of NB69 Cell Proliferation Implication of Free Radicals. Int J Mol Sci. 2016;17:510 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
磷酸化ERK1/ERK2(Thr185, Tyr187)多克隆抗体
目录# :
44-680G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
Bovine, C. elegans, Chicken, Drosophila, Human, Mouse, Rat, Xenopus laevis
应用 :
Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000
物种 :
Bovine, C. elegans, Chicken, Drosophila, Human, Mouse, Rat, Xenopus laevis
抗体亚型 :
IgG
储存 :
-20°C
描述 :
ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human ERK1&2 that contains threonine 202/185 and tyrosine 204/187. This region is conserved among many species including rat, mouse, cow, frog, snail, nematode, and fruit fly.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:10-1:100, Western Blot: 1:1,000
别名 :
12559; 9030612K14Rik; AA407128; AU018647; BcDNA:RE08694; C78273; CG12559; CG12559-PA; CG12559-PC; CG12559-PD; CG12559-PE; CG12559-PG; CG12559-PH; CG12559-PI; CG18732; CT34260; CT39192; DERK; D-ERK; DERK-A; Diphospho-ERK; dm-dpERK; Dmel CG12559; Dmel_CG12559; DmErk; DmERKA; DmERK-A; DmMAPK; dpERK; dp-ERK; dpERK1; dpMAPK; drosophila ERK; Dsor2; E(sina)7; EC2-1; EK2-1; enhancer of seven in absentia 7; ERK; Erk MAP kinase; Erk/Map kinase; ERK/rolled; Erk1; Erk-1; erk1 erk2; Erk1/2; ERK1b; ERK2; ERK-2; ERKA; ERK-A; ERT1; ERT2; Esrk1; extracellular signal-regulated kinase; extracellular signal-regulated kinase (ERK2); extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; extracellular signal-regulated kinase A; extracellular signal-regulated kinase-1; extracellular signal-regulated kinase-2; extracellular signal-related kinase 1; Extracellular-regulated kinase A; extracellular-signal-regulated kinase 2; Extracellular-signal-related kinase A; EY2-2; fi06b09; GroupII; HS44KDAP; HUMKER1A; I79_009500; I79_018350; insulin-stimulated MAP2 kinase; l(2)41Ac; l(2R)EMS45-39; M phase MAP kinase; MAP kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MapK; MAP-k; MAPK 1; MAPK 2; MAPK 3; MAPK1; mapk1.S; mapk1a; mapk1-a; mapk1-b; mapk2; mapk3; MAP-kinase; MBP kinase; Microtubule-associated protein 2 kinase; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen-activated 3; mitogen-activated protein kinase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 1 S homeolog; mitogen-activated protein kinase 1a; mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; Mitogen-activated protein kinase ERK-A; MNK1; mpk1; Mtap2k; Myelin basic protein kinase; Myelin xP42 protein kinase; p38; p40; p41; p41mapk; p42; p42 MAP Kinase; P42MAPK; p42-MAPK; p44; p44 MAP kinase; p44erk1; p44-ERK1; p44mapk; p44-MAPK; pERK; p-ERK; phospho-ERK; pMapK; pp42/MAP kinase; Prkm1; PRKM2; Prkm3; protein kinase; Protein rolled; protein tyrosine kinase ERK2; RE08694p; RL; rl/ERK; rl/MAPK; rll; rl-PA; rl-PC; rl-PD; rl-PE; rl-PG; rl-PH; rl-PI; roll; rolled; sem; sevenmaker; SR2-1; Su(Raf)2B; wu:fi06b09; XELAEV_18010534mg; xp42; zERK1; zERK2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国