产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Paxillin (Tyr118) Polyclonal Antibody
目录 :
44-722G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, , 非洲爪蛙
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
文章摘录数: 53
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 2a
Shaaya M, Fauser J, Zhurikhina A, Conage Pough J, Huyot V, Brennan M, et al. Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity. elife. 2020;9: pubmed 出版商
  • 免疫细胞化学; 人类; 图 5d
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, et al. A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. 2018;100:799-815.e7 pubmed 出版商
  • 免疫印迹; 人类; 图 s8a
Mekhdjian A, Kai F, Rubashkin M, Prahl L, Przybyla L, McGregor A, et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017;28:1467-1488 pubmed 出版商
  • 免疫印迹; 犬; 图 4c
Zhang W, Gunst S. Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction. J Physiol. 2017;595:4279-4300 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4D
Oudin M, Miller M, Klazen J, Kosciuk T, Lussiez A, Hughes S, et al. MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis. Mol Biol Cell. 2016;27:3085-3094 pubmed
  • 免疫细胞化学; 人类; 图 1
Fokkelman M, BalcıoÄŸlu H, Klip J, Yan K, Verbeek F, Danen E, et al. Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour. Sci Rep. 2016;6:31707 pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 1
Harizanova J, Fermin Y, Malik Sheriff R, Wieczorek J, Ickstadt K, Grecco H, et al. Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions. PLoS ONE. 2016;11:e0160591 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 3
Farrugia A, Calvo F. Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts. Small Gtpases. 2017;8:49-57 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Freeman S, Christian S, Austin P, Iu I, Graves M, Huang L, et al. Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. J Cell Sci. 2017;130:152-163 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:400; 图 s3
Kumar A, Ouyang M, van den Dries K, McGhee E, Tanaka K, Anderson M, et al. Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity. J Cell Biol. 2016;213:371-83 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1e
Nader G, Ezratty E, Gundersen G. FAK, talin and PIPKI? regulate endocytosed integrin activation to polarize focal adhesion assembly. Nat Cell Biol. 2016;18:491-503 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 6
  • 免疫印迹; 人类; 1:500; 图 5
Horton E, Humphries J, Stutchbury B, Jacquemet G, Ballestrem C, Barry S, et al. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol. 2016;212:349-64 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Theodosiou M, Widmaier M, Böttcher R, Rognoni E, Veelders M, Bharadwaj M, et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. elife. 2016;5:e10130 pubmed 出版商
  • 免疫组化; 非洲爪蛙; 1:100; 图 4
Tandon P, Wilczewski C, Williams C, Conlon F. The Lhx9-integrin pathway is essential for positioning of the proepicardial organ. Development. 2016;143:831-40 pubmed 出版商
Fauser J, Huyot V, Matsche J, Szynal B, Alexeev Y, Kota P, et al. Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity. J Cell Biol. 2022;221: pubmed 出版商
Ma J, Bi L, Spurlin J, Lwigale P. Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development. elife. 2022;11: pubmed 出版商
Guo Y, Mei F, Huang Y, Ma S, Wei Y, Zhang X, et al. Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis. Bioact Mater. 2022;7:364-376 pubmed 出版商
Malchiodi Z, Cao H, Gay M, Safronenka A, Bansal S, Tucker R, et al. Cholecystokinin Receptor Antagonist Improves Efficacy of Chemotherapy in Murine Models of Pancreatic Cancer by Altering the Tumor Microenvironment. Cancers (Basel). 2021;13: pubmed 出版商
Weiße J, Rosemann J, Muller L, Kappler M, Eckert A, Glaß M, et al. Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation. Mol Cancer. 2021;20:88 pubmed 出版商
Arts J, Mahlandt E, Schimmel L, Grönloh M, Van Der Niet S, Klein B, et al. Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling. Front Immunol. 2021;12:667213 pubmed 出版商
Majstrowicz K, Honnert U, Nikolaus P, Schwarz V, Oeding S, Hemkemeyer S, et al. Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19. J Cell Sci. 2021;134: pubmed 出版商
Wu Y, Huang Y, Zhang W, Gunst S. The proprotein convertase furin inhibits IL-13-induced inflammation in airway smooth muscle by regulating integrin-associated signaling complexes. Am J Physiol Lung Cell Mol Physiol. 2021;321:L102-L115 pubmed 出版商
Mousson A, Legrand M, Steffan T, Vauchelles R, Carl P, Gies J, et al. Inhibiting FAK-Paxillin Interaction Reduces Migration and Invadopodia-Mediated Matrix Degradation in Metastatic Melanoma Cells. Cancers (Basel). 2021;13: pubmed 出版商
Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, et al. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep. 2021;22:e48961 pubmed 出版商
Kilinc A, Han S, Barrett L, Anandasivam N, Nelson C. Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1. Mol Biol Cell. 2021;32:402-412 pubmed 出版商
Lee Y, Finch Edmondson M, Cognart H, Zhu B, Song H, Low B, et al. Common and Unique Transcription Signatures of YAP and TAZ in Gastric Cancer Cells. Cancers (Basel). 2020;12: pubmed 出版商
Chen K, Jiao X, Di Rocco A, Shen D, Xu S, Ertel A, et al. Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation. Cell Rep. 2020;32:108151 pubmed 出版商
Zhang W, Gunst S. S100A4 is activated by RhoA and catalyses the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle. J Physiol. 2020;598:4573-4590 pubmed 出版商
Huang Y, Gunst S. Phenotype transitions induced by mechanical stimuli in airway smooth muscle are regulated by differential interactions of parvin isoforms with paxillin and Akt. Am J Physiol Lung Cell Mol Physiol. 2020;318:L1036-L1055 pubmed 出版商
Schimmel L, Fukuhara D, Richards M, Jin Y, Essebier P, Frampton E, et al. c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development. 2020;147: pubmed 出版商
van der Stoel M, Schimmel L, Nawaz K, van Stalborch A, de Haan A, Klaus Bergmann A, et al. DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis. J Cell Sci. 2020;133: pubmed 出版商
Jaumouillé V, Cartagena Rivera A, Waterman C. Coupling of β2 integrins to actin by a mechanosensitive molecular clutch drives complement receptor-mediated phagocytosis. Nat Cell Biol. 2019;21:1357-1369 pubmed 出版商
Dorland Y, Cornelissen A, Kuijk C, Tol S, Hoogenboezem M, van Buul J, et al. Nuclear shape, protrusive behaviour and in vivo retention of human bone marrow mesenchymal stromal cells is controlled by Lamin-A/C expression. Sci Rep. 2019;9:14401 pubmed 出版商
Osborne N, Sundseth R, Gay M, Cao H, Tucker R, Nadella S, et al. Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases. Am J Physiol Gastrointest Liver Physiol. 2019;317:G682-G693 pubmed 出版商
Pedrosa A, Bodrug N, Gómez Escudero J, Carter E, Reynolds L, Georgiou P, et al. Tumor angiogenesis is differentially regulated by phosphorylation of endothelial cell focal adhesion kinase tyrosines-397 and -861. Cancer Res. 2019;: pubmed 出版商
Klomp J, Shaaya M, Matsche J, Rebiai R, Aaron J, Collins K, et al. Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response. Cell Chem Biol. 2019;: pubmed 出版商
Rezey A, Gerlach B, Wang R, Liao G, Tang D. Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma. Sci Rep. 2019;9:7555 pubmed 出版商
Godoy Parejo C, Deng C, Liu W, Chen G. Insulin Stimulates PI3K/AKT and Cell Adhesion to Promote the Survival of Individualized Human Embryonic Stem Cells. Stem Cells. 2019;37:1030-1041 pubmed 出版商
Tsygankova O, Keen J. A unique role for clathrin light chain A in cell spreading and migration. J Cell Sci. 2019;132: pubmed 出版商
Jones M, Askari J, Humphries J, Humphries M. Cell adhesion is regulated by CDK1 during the cell cycle. J Cell Biol. 2018;217:3203-3218 pubmed 出版商
Roycroft A, Szabo A, Bahm I, Daly L, Charras G, Parsons M, et al. Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest. Dev Cell. 2018;45:565-579.e3 pubmed 出版商
Sun X, Hourwitz M, Baker E, Schmidt B, Losert W, Fourkas J. Replication of biocompatible, nanotopographic surfaces. Sci Rep. 2018;8:564 pubmed 出版商
Stutchbury B, Atherton P, Tsang R, Wang D, Ballestrem C. Distinct focal adhesion protein modules control different aspects of mechanotransduction. J Cell Sci. 2017;130:1612-1624 pubmed 出版商
Cieniewicz A, Kirchner T, Hinke S, Nanjunda R, D AQUINO K, Boayke K, et al. Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance. Diabetes. 2017;66:206-217 pubmed 出版商
Tomas N, Hoxha E, Reinicke A, Fester L, Helmchen U, Gerth J, et al. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. J Clin Invest. 2016;126:2519-32 pubmed 出版商
Zimnicka A, Husain Y, Shajahan A, Sverdlov M, Chaga O, Chen Z, et al. Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae. Mol Biol Cell. 2016;27:2090-106 pubmed 出版商
Calvo F, Ranftl R, Hooper S, Farrugia A, Moeendarbary E, Bruckbauer A, et al. Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts. Cell Rep. 2015;13:2699-714 pubmed 出版商
Wu J, Chen Y, Kuo C, Wenshin Yu H, Chen Y, Chiou A, et al. Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration. Sci Rep. 2015;5:18476 pubmed 出版商
Horton E, Byron A, Askari J, Ng D, Millon Frémillon A, Robertson J, et al. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly. Nat Cell Biol. 2015;17:1577-1587 pubmed 出版商
Jiang J, Zhang Z, Yuan X, Poo M. Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons. J Cell Biol. 2015;209:759-74 pubmed 出版商
Case L, Baird M, Shtengel G, Campbell S, Hess H, Davidson M, et al. Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions. Nat Cell Biol. 2015;17:880-92 pubmed 出版商
Robertson J, Jacquemet G, Byron A, Jones M, Warwood S, Selley J, et al. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun. 2015;6:6265 pubmed 出版商
Balcioglu H, van Hoorn H, Donato D, Schmidt T, Danen E. The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions. J Cell Sci. 2015;128:1316-26 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Phospho-Paxillin (Tyr118) Polyclonal Antibody
目录# :
44-722G
规格 :
100微升
价格 :
美国425.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类, 小鼠
应用 :
Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
物种 :
人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human paxillin that contains tyrosine 118.
格式 :
液体
应用w/稀释 :
Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000
别名 :
adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; pxn; pxna; testicular tissue protein Li 134; TGFB1I1; transforming growth factor beta 1 induced transcript 1; wu:fw71f12
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国