产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化EIF2S1(Ser52)多克隆抗体
目录 :
44-728G
规格 :
100微升
价格 :
美国375.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, brewer's yeast, , roundworm
应用 :
免疫印迹, 免疫细胞化学
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 4c
Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021;24:102758 pubmed 出版商
  • 免疫印迹; 人类; 图 s3f
Guillén Boixet J, Kopach A, Holehouse A, Wittmann S, Jahnel M, Schlüßler R, et al. RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation. Cell. 2020;181:346-361.e17 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500; 图 7h
Santos M, Anderson C, Neschen S, Zumbrennen Bullough K, Romney S, Kahle Stephan M, et al. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nat Commun. 2020;11:296 pubmed 出版商
  • 免疫印迹; brewer's yeast; 1:1000; 图 3f
Tye B, Commins N, Ryazanova L, Wühr M, Springer M, Pincus D, et al. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2a
Kaufman D, Papillon J, Larose L, Iwawaki T, Cybulsky A. Deletion of inositol-requiring enzyme-1? in podocytes disrupts glomerular capillary integrity and autophagy. Mol Biol Cell. 2017;28:1636-1651 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s3i
Villar V, Nguyen T, Delcroix V, Terés S, Bouchecareilh M, Salin B, et al. mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation. Nat Commun. 2017;8:14124 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 1a
Silva R, Sattlegger E, Castilho B. Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response. J Cell Sci. 2016;129:4521-4533 pubmed
  • 免疫印迹; 大鼠; 图 6a
Ayuso M, Martínez Alonso E, Regidor I, Alcazar A. Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. J Biol Chem. 2016;291:27252-27264 pubmed 出版商
  • 免疫印迹; roundworm ; 图 1a
Ferraz R, Camara H, De Souza E, Pinto S, Pinca A, Silva R, et al. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. BMC Biol. 2016;14:87 pubmed
  • 免疫印迹; 人类; 1:1000; 图 5d
  • 免疫印迹; 小鼠; 1:1000; 图 1c
Khoutorsky A, Sorge R, Prager Khoutorsky M, Pawlowski S, Longo G, Jafarnejad S, et al. eIF2? phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016;113:11949-11954 pubmed
  • 免疫印迹; 人类; 图 5
Mohammad S, Wolfe L, Stöbe P, Biskup S, Wainwright M, Melin Aldana H, et al. Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15B. J Pediatr. 2016;179:144-149.e2 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Zhu S, Henninger K, McGrath B, Cavener D. PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility. PLoS ONE. 2016;11:e0162766 pubmed 出版商
  • 免疫印迹; 人类; 图 8
Nelson E, Schmidt K, Deflubé L, DoÄŸanay S, Banadyga L, Olejnik J, et al. Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions. J Virol. 2016;90:7268-7284 pubmed 出版商
  • 免疫印迹; 猫; 图 1
  • 免疫印迹; 小鼠; 图 8
Humoud M, Doyle N, Royall E, Willcocks M, Sorgeloos F, van Kuppeveld F, et al. Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage. J Virol. 2016;90:6489-6501 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 3a
Kainulainen M, Lau S, Samuel C, Hornung V, Weber F. NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and ?-TRCP1 To Degrade the Antiviral Protein Kinase PKR. J Virol. 2016;90:6140-7 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Zhong L, Wang L, Xu L, Liu Q, Jiang L, Zhi Y, et al. The cytotoxic effect of the NOS-mediated oxidative stress in MCF-7 cells after PbClâ‚‚ exposure. Environ Toxicol. 2016;31:601-8 pubmed 出版商
Kiparaki M, Khan C, Folgado Marco V, Chuen J, Moulos P, Baker N. The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function. elife. 2022;11: pubmed 出版商
Chen Y, Cao S, Chen H, Yin C, Xu X, Yang Z. Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway. Arq Bras Cardiol. 2021;117:1134-1144 pubmed 出版商
Hong J, Park E, Lee J, Lee Y, Rooney B, Park Y. Exercise training mitigates ER stress and UCP2 deficiency-associated coronary vascular dysfunction in atherosclerosis. Sci Rep. 2021;11:15449 pubmed 出版商
Ohtsuka H, Kobayashi M, Shimasaki T, Sato T, Akanuma G, Kitaura Y, et al. Magnesium depletion extends fission yeast lifespan via general amino acid control activation. Microbiologyopen. 2021;10:e1176 pubmed 出版商
Weiss B, Allen G, Kloehn J, Abid K, Jaquier Gubler P, Curran J. eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome. Nucleic Acids Res. 2021;49:5159-5176 pubmed 出版商
Mendes A, Gigan J, Rodríguez Rodrígues C, Choteau S, Sanséau D, Barros D, et al. Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. Life Sci Alliance. 2021;4: pubmed 出版商
Muller R, Meacham Z, Ferguson L, Ingolia N. CiBER-seq dissects genetic networks by quantitative CRISPRi profiling of expression phenotypes. Science. 2020;370: pubmed 出版商
Schneider K, Nelson G, Watson J, Morf J, Dalglish M, Luh L, et al. Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation. Cell Rep. 2020;32:108154 pubmed 出版商
De Zoysa T, Phizicky E. Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences. PLoS Genet. 2020;16:e1008893 pubmed 出版商
Wuerth J, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti Furga G, et al. eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition. MBio. 2020;11: pubmed 出版商
Hong J, Hong S, Lee J, Park J, Eriksen J, Rooney B, et al. Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer's disease: role of the P2Y2 receptor and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol. 2020;318:H1559-H1569 pubmed 出版商
Alvarez Castelao B, Tom Dieck S, Fusco C, Donlin Asp P, Perez J, Schuman E. The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition. elife. 2020;9: pubmed 出版商
Dörrbaum A, Alvarez Castelao B, Nassim Assir B, Langer J, Schuman E. Proteome dynamics during homeostatic scaling in cultured neurons. elife. 2020;9: pubmed 出版商
Guo X, Aviles G, Liu Y, Tian R, Unger B, Lin Y, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427-432 pubmed 出版商
Rodriguez C, Chun S, Mills R, Todd P. Translation of upstream open reading frames in a model of neuronal differentiation. BMC Genomics. 2019;20:391 pubmed 出版商
An H, Ordureau A, Paulo J, Shoemaker C, Denic V, Harper J. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. Mol Cell. 2019;74:891-908.e10 pubmed 出版商
Fusade Boyer M, Dupré G, Bessière P, Khiar S, Quentin Froignant C, Beck C, et al. Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections. Front Immunol. 2019;10:134 pubmed 出版商
Anglès F, Hutt D, Balch W. HDAC inhibitors rescue multiple disease-causing CFTR variants. Hum Mol Genet. 2019;28:1982-2000 pubmed 出版商
Hodgson R, Varanda B, Ashe M, Allen K, Campbell S. Cellular eIF2B subunit localization: implications for the integrated stress response and its control by small molecule drugs. Mol Biol Cell. 2019;30:942-958 pubmed 出版商
van Galen P, Mbong N, Kreso A, Schoof E, Wagenblast E, Ng S, et al. Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia. Cell Rep. 2018;25:1109-1117.e5 pubmed 出版商
Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018;174:1216-1228.e19 pubmed 出版商
Taga M, Mouton Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, et al. PKR modulates abnormal brain signaling in experimental obesity. PLoS ONE. 2018;13:e0196983 pubmed 出版商
White M, Schroeder R, Zhu K, Xiong K, McConkey D. HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells. Oncogene. 2018;37:4413-4427 pubmed 出版商
Diedrichs D, Gomez J, Huang C, Rutkowski D, Curtu R. A data-entrained computational model for testing the regulatory logic of the vertebrate unfolded protein response. Mol Biol Cell. 2018;29:1502-1517 pubmed 出版商
Cubas Gaona L, Diaz Beneitez E, Ciscar M, Rodriguez J, Rodriguez D. Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha. J Virol. 2018;92: pubmed 出版商
Lee I, Ho X, George S, Goh C, Sundaram J, Pang K, et al. Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. Cell Death Differ. 2018;25:255-267 pubmed 出版商
Lee S, Ramesh R, de Boor V, Gebler J, Silva R, Sattlegger E. Cost-effective and rapid lysis of Saccharomyces cerevisiae cells for quantitative western blot analysis of proteins, including phosphorylated eIF2α. Yeast. 2017;34:371-382 pubmed 出版商
Hasegawa H, Hsu A, Tinberg C, Siegler K, Nazarian A, Tsai M. Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2? phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic. MAbs. 2017;9:854-873 pubmed 出版商
Yuan W, Guo S, Gao J, Zhong M, Yan G, Wu W, et al. General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae. J Biol Chem. 2017;292:2660-2669 pubmed 出版商
Legrand N, Jaquier Gubler P, Curran J. The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells. Nucleic Acids Res. 2015;43:8392-404 pubmed 出版商
Silva R, Dautel M, Di Genova B, Amberg D, Castilho B, Sattlegger E. The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast. PLoS ONE. 2015;10:e0131070 pubmed 出版商
Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, et al. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nat Commun. 2015;6:7520 pubmed 出版商
Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, et al. Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression. J Biol Chem. 2015;290:15758-69 pubmed 出版商
Bettaieb A, Jiang J, Sasaki Y, Chao T, Kiss Z, Chen X, et al. Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. Gastroenterology. 2015;149:468-80.e10 pubmed 出版商
Das I, Krzyzosiak A, Schneider K, Wrabetz L, D Antonio M, Barry N, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348:239-42 pubmed 出版商
Sidrauski C, McGeachy A, Ingolia N, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. elife. 2015;4: pubmed 出版商
Wang S, Park S, Kodali V, Han J, Yip T, Chen Z, et al. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Mol Biol Cell. 2015;26:594-604 pubmed 出版商
Zhong L, Wang L, Xu L, Liu Q, Jiang L, Zhi Y, et al. The role of NOS-mediated ROS accumulation in an early phase Cu-induced acute cytotoxicity in MCF-7 cells. Biometals. 2015;28:113-22 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
磷酸化EIF2S1(Ser52)多克隆抗体
目录# :
44-728G
规格 :
100微升
价格 :
美国375.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类, 小鼠, 酵母
应用 :
Immunocytochemistry: Assay-dependent, Western Blot: 1:1,000
物种 :
人类, 小鼠, 酵母
抗体亚型 :
IgG
储存 :
-20°C
描述 :
EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
免疫原 :
The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human eIF2a that contains serine 52. This region is conserved among many species including rat, pig, cow, fruit fly and yeast.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-dependent, Western Blot: 1:1,000
别名 :
0910001O23Rik; 2410026C18Rik; 35kDa; EIF2; EIF-2; eIF2 alpha; eIF2 alpha subunit; EIF2A; eIF-2A; eIF2alpha; EIF-2alpha; eIF-2-alpha; EIF2S1; eif2s1b; Eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit 1b; eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 alpha b; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A; fb19d01; translation initiation factor subunit; wu:fb19d01
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国