产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
PDHA1单克隆抗体(9H9AF5)
目录 :
459400
规格 :
100微克
价格 :
425美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
9H9AF5
反应物种 :
人类, 小鼠, 大鼠, 牛
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4b
Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, et al. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Rep. 2019;27:3587-3601.e4 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 6c
Santacatterina F, Sánchez Aragó M, Catalán García M, Garrabou G, de Arenas C, Grau J, et al. Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis. J Transl Med. 2017;15:29 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Takahashi Y, Tamura Y, Matsunaga Y, Kitaoka Y, Terada S, Hatta H. Effects of Taurine Administration on Carbohydrate Metabolism in Skeletal Muscle during the Post-Exercise Phase. J Nutr Sci Vitaminol (Tokyo). 2016;62:257-264 pubmed
  • 免疫印迹; 小鼠
Goguet Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, et al. E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis. Proc Natl Acad Sci U S A. 2016;113:11004-9 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Titov D, Cracan V, Goodman R, Peng J, Grabarek Z, Mootha V. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science. 2016;352:231-5 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Jiang L, Shestov A, Swain P, Yang C, Parker S, Wang Q, et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature. 2016;532:255-8 pubmed 出版商
  • 免疫印迹; 小鼠
Kerr E, Gaude E, Turrell F, Frezza C, Martins C. Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities. Nature. 2016;531:110-3 pubmed 出版商
  • 免疫印迹; 人类
Prabhu A, Sarcar B, Miller C, Kim S, Nakano I, Forsyth P, et al. Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis. Neuro Oncol. 2015;17:1220-30 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 6
Madhok B, Yeluri S, Perry S, Hughes T, Jayne D. Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer. 2010;102:1746-52 pubmed 出版商
Flicker D, Sancak Y, Mick E, Goldberger O, Mootha V. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019;27:1364-1375.e5 pubmed 出版商
Yao C, Wang R, Wang Y, Kung C, Weber J, Patti G. Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation. elife. 2019;8: pubmed 出版商
Miotto P, McGlory C, Holloway T, Phillips S, Holloway G. Sex differences in mitochondrial respiratory function in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2018;314:R909-R915 pubmed 出版商
Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018;50:219-228 pubmed 出版商
Park S, Chang C, Safi R, Liu X, Baldi R, Jasper J, et al. ERR?-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep. 2016;15:323-35 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
PDHA1单克隆抗体(9H9AF5)
目录# :
459400
规格 :
100微克
价格 :
425美元
克隆性 :
单克隆
纯度 :
IgG分馏成分
宿主 :
小鼠
反应物种 :
牛, 人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 1 µg/mL, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Western Blot: 1.0 µg/mL
物种 :
牛, 人类, 小鼠, 大鼠
克隆 :
9H9AF5
抗体亚型 :
IgG1
储存 :
4° C, 不冻结
描述 :
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
免疫原 :
人类重组全长PDH E1甲
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1 µg/mL, Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Western Blot: 1.0 µg/mL
别名 :
PDHA; PDHA1; Pdha-1; PDHAD; PDHCE1A; PDHE1-A type I; PHE1A; pyruvate dehydrogenase; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component alpha subunit; pyruvate dehydrogenase E1 component alpha subunit precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1 subunit; pyruvate dehydrogenase E1 subunit alpha 1; pyruvate dehydrogenase E1alpha subunit
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国