CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), PerCP-eFluor™ 710, eBioscience

产品简要

公司名称 :

赛默飞世尔

其他品牌 :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

产品类型 :

抗体

产品名称 :

CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), PerCP-eFluor™ 710, eBioscience

46-1079-42

规格 :

100试验

价格 :

美国416

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

Percp/efluor 710

克隆名称 :

eBioH4A3

反应物种 :

人类

应用 :

流式细胞仪

更多信息或购买 :

赛默飞世尔产品网页

文章摘录数: 12

出版应用/物种/样本/稀释	参考文献
流式细胞仪; 人类; 图 s1b	Cuff A, Robertson F, Stegmann K, Pallett L, Maini M, Davidson B, et al. Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation. J Immunol. 2016;197:4283-4291 pubmed
	Hope J, Bersi M, Dombroski J, Clinch A, Pereles R, Merryman W, et al. Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death. J Cell Sci. 2021;134: pubmed 出版商
	Menasche B, Davis E, Wang S, Ouyang Y, Li S, Yu H, et al. PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Sci Adv. 2020;6: pubmed 出版商
	Sant S, Quiñones Parra S, Koutsakos M, Grant E, Loudovaris T, Mannering S, et al. HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. PLoS Pathog. 2020;16:e1008714 pubmed 出版商
	Stunnenberg M, van Pul L, Sprokholt J, van Dort K, Gringhuis S, Geijtenbeek T, et al. MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals. Viruses. 2020;12: pubmed 出版商
	Arbore G, West E, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, et al. Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun. 2018;9:4186 pubmed 出版商
	Sponaas A, Yang R, Rustad E, Standal T, Thoresen A, Dao Vo C, et al. PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients. Oncotarget. 2018;9:32024-32035 pubmed 出版商
	Singh N, Kulikovskaya I, Barrett D, Binder Scholl G, Jakobsen B, Martinez D, et al. T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma. Oncoimmunology. 2016;5:e1040216 pubmed
	Huynh C, Andrews N. The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis. EMBO Rep. 2005;6:843-7 pubmed
	Betts M, Koup R. Detection of T-cell degranulation: CD107a and b. Methods Cell Biol. 2004;75:497-512 pubmed
	Grützkau A, Smorodchenko A, Lippert U, Kirchhof L, Artuc M, Henz B. LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. Cytometry A. 2004;61:62-8 pubmed
	Sarafian V, Jadot M, Foidart J, Letesson J, van den Brule F, Castronovo V, et al. Expression of Lamp-1 and Lamp-2 and their interactions with galectin-3 in human tumor cells. Int J Cancer. 1998;75:105-11 pubmed

产品信息

产品类型 :

抗体

产品名称 :

CD107a (LAMP-1) Monoclonal Antibody (eBioH4A3), PerCP-eFluor™ 710, eBioscience

目录# :

46-1079-42

规格 :

100试验

定价 :

美国416

克隆性 :

单克隆

纯度 :

亲和色谱

宿主 :

小鼠

反应物种 :

人类

应用 :

Flow Cytometry: 5 µL (0.25 µg)/test

物种 :

人类

克隆 :

eBioH4A3

抗体亚型 :

IgG1, kappa

储存 :

4° C, store in dark, DO NOT FREEZE!

描述 :

LAMP1 (CD107a, lysosome-associated membrane protein-1) together with LAMP-2, is a major constituent of lysosomal membrane, 1-2% of total CD107a is found also on the plasma membrane. LAMP1 is a heavily glycosylated membrane protein which contains a putative signal peptide, 18 sites for N-linked glycosylation, a single membrane-spanning segment and a short (11 amino acid) cytosolic tail. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes. LAMP1 is a type 1 integral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1, and this mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 (and LAMP2) have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore, they are possibly involved in the adhesion of PBMC to the site of inflammation. Increased LAMP1 immunoreactivity is observed in neurons and glial cells surrounding senile plaques in Alzheimer’s Disease (AD) cases, and is localized in medullary epithelial cells, single macrophages and lymphocytes in acute thymic involution. LAMP1 is a good marker of mast cell activation.

格式 :

液体

应用w/稀释 :

Flow Cytometry: 5 µL (0.25 µg)/test

别名 :

120 kDa lysosomal membrane glycoprotein; AI196048; CD107 antigen-like family member A; CD107a; I79_011073; Lamp I; LAMP1; LAMP-1; LAMPA; LGP120; LGP-120; LGPA; LGP-A; lysosomal associated membrane protein 1; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosomal membrane glycoprotein A; lysosomal-associated membrane protein 1; lysosome-associated membrane glycoprotein 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B); lysosome-associated membrane protein 1; P2B

更多信息或购买 :

赛默飞世尔产品网页

公司信息

赛默飞世尔

上海浦东新金桥路27号7号楼

analyze.cn@thermofisher.com

http://www.thermo.com.cn

1084193588

公司总部: 美国