产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Toll样受体4多克隆抗体
目录 :
48-2300
规格 :
100微克
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 流式细胞仪
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 4
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 大鼠; 1:500; 图 2
Famakin B, Tsymbalyuk O, Tsymbalyuk N, Ivanova S, Woo S, Kwon M, et al. HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia. Neurol Res Int. 2020;2020:3929438 pubmed 出版商
Hussain S, Johnson C, Sciurba J, Meng X, Stober V, Liu C, et al. TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. elife. 2020;9: pubmed 出版商
Zhang L, Chen Q, Wang H, Yang J, Sheng S. Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway. Mol Med Rep. 2018;18:5427-5436 pubmed 出版商
Bueno Silva B, Kawamoto D, Ando Suguimoto E, Alencar S, Rosalen P, Mayer M. Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS ONE. 2015;10:e0144954 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Toll样受体4多克隆抗体
目录# :
48-2300
规格 :
100微克
价格 :
425美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 20 µg x 10^6 cells, Immunoprecipitation: Assay Dependent, Western Blot: 1:50-1:200
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
免疫原 :
Synthetic peptide derived from the C-terminal region of the mouse TLR4 protein (Accession# NP_067272, Q9QUK6), which is identical to rat and 94% homologous to human.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 20 µg x 10^6 cells, Immunoprecipitation: Assay Dependent, Western Blot: 1:50-1:200
别名 :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国